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| 1 | 骨吸收抑制剂对老年短尾猴椎体松质骨微损伤和骨重建的影响显示文摘目的 评估骨吸收抑制剂对骨微损伤和骨重建的影响.方法将20只雌性短尾猴(18~22岁)按体重随机分为5组:对照组(CNT,n=4),低剂量依降钙素组[0.5 U/(kg·d),ELL,n=4],高剂量依降钙素组[5 U/(kg·d),ELH,n=4],低剂量阿仑膦酸盐组[10 μg/(kg·d),ALL,n=4]和高剂量阿仑膦酸盐组[100 μg(kg·d),ALH,n=4].所有动物均皮下注射给药,每周2次,持续给药29周.处死前给予钙黄绿素双标,处死后取胸椎第2椎体进行松质骨微损伤测量及骨重建指标检测.结果 微损伤测量结果表明2个阿仑膦酸盐组椎体的微损伤总裂缝长度(crack length)、裂缝总数量(crack number)、骨表面密度(surface density)及裂缝密度(crack density)均较对照组和依降钙素组明显增加(P<0.01),但微损伤平均长度(mean crack length)较对照组和依降钙素组明显降低(P<0.05).高剂量降钙素组骨表面密度较对照组明显增高(P<0.01),其余各指标间差异均无统计学意义.骨重建检测结果表明阿仑膦酸盐组椎骨单标表面(sLS)、类骨质表面/骨表面(OS/BS)、类骨质厚度(O.Th)及单标表面/骨表面(sLS/BS)均较对照组明显降低(P<0.05);高剂量阿仑膦酸盐组矿化表面/类骨质表面(MS/OS)和标记表面/类骨质表面(LS/OS)较对照组明显减低(P<0.05).高剂量依降钙素组矿化表面/类骨质表面(OS/BS)和类骨质厚度(O.Th)较对照组明显降低(P<0.05),依降钙素组其余指标差异均无统计学意义.结论 依降钙素可轻微抑制老年短尾猴椎体松质骨的骨重建,但未引起骨微损伤的聚积;阿仑膦酸盐可显著抑制该猴椎体松质骨的骨重建,以及引起微损伤的聚积,但微损伤的平均长度明显降低. | 王瑞 曹永平 刘恒 杨昕 孟志超 吴浩 王京 Mashiba T Morri J | 2013 | 中华骨质疏松和骨矿盐疾病杂志2013，6，4： | 4 |
| 2 | 双膦酸盐的长期治疗增加了骨单位的矿化程度显示文摘目的评估双膦酸盐的长期应用对骨单位的次级矿化程度的影响。方法30只1岁龄猎犬按体重随机分成三组(每组雌雄各5只):对照组犬每天口服乳糖,低剂量组和高剂量组犬分别每天口服因卡膦酸钠incadronate0.3mgkg和0.6mgkg。所有犬持续给药3a。处死前进行四环素双标,处死后取左侧第9肋骨进行组织形态计测和次级矿化程度评估。结果组织形态计测表明两个双膦酸盐治疗组的骨激活频率(Ac.f)都明显低于对照组,分别降低了40%和82%。矿化程度的测定表明,低剂量和高剂量双膦酸盐组骨单位内的平均矿化程度(MDMB)都明显高于对照组,分别增加了22%和30%。双膦酸盐组MDMB分布曲线与对照组保持了相同的峰值,并且随治疗剂量的增大逐渐向高矿化端漂移。结论双膦酸盐长期应用明显抑制了骨转换,增加了骨单位的矿化程度。 | 曹永平 Tasuku Mashiba Satoshi Mori | 2006 | 中国骨质疏松杂志2006，12，2： | 4 |
| 3 | Recurrence of autoimmune hepatitis after liver transplantation without elevation of alanine aminotransferase显示文摘It is controversial whether steroid therapy should be continued to prevent the recurrence of autoimmune hepatitis(AIH)in patients who have undergone liver transplantation(LTx)due to AIH.We report a case of recurrent autoimmune hepatitis after LTx despite a persistently normal range of alanine aminotransferase(ALT).A 50-year-old woman was admitted to our hospital because of jaundice and severe liver dysfunction,where she was diagnosed with liver failure due to AIH.Steroid therapy was not effective enough and the patient received living-donor LTx in 1999.Following the operation,the level of ALT was maintained within a normal range and anti-nuclear antibody(ANA)became negative,however,the serum level of IgG gradually elevated and ANA became positive,while platelets decreased.A liver biopsy performed 6 years after LTx showed histological findings of AIH and she was diagnosed with recurrent AIH.A recurrence of AIH may occur after LTx even if the level of ALT remains within a normal range.We consider that a protocol liver biopsy should be performed in patients who undergo LTx due to AIH to decide the indication for steroid therapy. | Huaiqi Yao Kojiro Michitaka Yoshio Tokumoto Yosuke Murata Toshie Mashiba Masanori Abe Yoichi Hiasa Norio Horiike Morikazu Onji | 2007 | World Journal of Gastroenterology2007，13，10： | 3 |
| 4 | 长期大剂量双膦酸盐应用是否会导致骨过度矿化显示文摘目的评估双膦酸盐的长期应用对骨单位次级矿化程度以及骨的生物力学特性的影响。方法30只猎犬,犬龄1年,按体重分成3组(每组雌雄各5只):分别每天给予口服因卡膦酸钠0.3mg·kg^-1(低剂量组)和0.6mg·kg^-1(高剂量组),对照组犬给予口服乳糖(12mg·kg^-1·d^-1),并持续给药3年。处死前进行四环素双标,处死后取左侧第九肋骨进行组织形态计测、生物力学测定和次级矿化程度评估。结果组织形态计测表明低剂量和高剂量双膦酸盐组每年的骨激活频率分别是(4.93±0.92)个/mm^2和(2.50±0.78)个/mm^2,两者都明显低于对照组(7.83±0.96)个/mm^2。低剂量和高剂量组骨单位的平均矿化程度分别为(1.40±0.12)铝箔数和(1.48±0.09)铝箔数,都明显高于对照组(1.07±0.06)铝箔数,分别增加了31%和38%。骨的内在材料特性(最大应力、弹性模量和刚度)在3个组之间的差异无统计学意义。结论双膦酸盐长期应用明显抑制了骨转换,增加了骨单位的矿化程度,但未导致过度矿化而损害骨的内在材料特性。 | 刘超 曹永平 杨昕 Tasuku Mashiba Satoshi Mori | 2009 | 中华医学杂志2009，89，42： | 3 |
| 5 | A serum amyloid A and LDL complex as a new prognostic marker in stable coronary artery disease显示文摘 | Ogasawara K Mashiba S Wada Y | 2004 | Atherosclerosis2004，174，： | 1 |
| 6 | Raloxifene,estro-gen,and alendronate affect the processes of fracture repair differently in ovariectomized rats显示文摘 | Cao Y Mori S Mashiba T | 2002 | J Bone Miner Res2002，17，12： | 1 |
| 7 | Effects of human parathyroid hormone(1-34),LY333334,on bone mass,remodeling,and mechanical properties of cortical bone during the first remodeling cycle in rabbits显示文摘 | Mashiba T Burr DB Turner CH | 2001 | Bone2001，28，5： | 1 |
| 8 | Low-density lipoprotein (LDL), which includes apolipoprotein A-I (apoAI-LDL) as a novel marker of coronary artery disease显示文摘 | Ogasawara K Mashiba S Hashimoto H | 2008 | Clin China Acta2008，397，12： | 1 |
| 9 | Expressions of Vascular endothelial growth factor in nonparenchymal as well as parenchymal cells in rat liver after necrosis显示文摘 | Ishikawa K Moehida S Mashiba S | 1999 | Biochem Biophys Res Commun1999，254，： | 1 |
| 10 | Expression of vascular endothelial growth factor in nonparenchymal as well as parnchymal cells in rat liver after necrosis显示文摘 | Ishikawa K Mochida S Mashiba S | 1999 | Biochem Biphys Res Commun1999，254，3： | 1 |
| 11 | A serum amyloid A and LDL complex as a new prognostic marker in stabke coronary artery disease显示文摘 | Ogasawara K Mashiba S Wada Y | 2004 | Atherosclerosis2004，174，2： | 1 |
| 12 | Present status of autoimmune hepatitis in Japan: a nationwide survey 显示文摘 | ABE M MASHIBA T ZENIYA M | 2011 | J Gastroenterol2011，46，9： | 1 |
| 13 | Raloxifene,estrogen,and alendronate affect the processes of fracture repair differently in ovariectomized rats显示文摘 | Cao Y Mori S Mashiba T | 2002 | J Bone Miner Res2002，17，12： | 1 |
| 14 | Suppressed bone turnover by bisphosphonates increases microdamage ac-cumulation and reduces some biomechanical properties in dog rib显示文摘 | Mashiba T Hirano T Turner CH | 2000 | J Bone Miner Res2000，15，4： | 1 |
| 15 | 1Alpha,25-dihydroxy-2beta(3-hydroxypropoxy)vitamin D3(ED-71)suppressed callus remodeling but did not in terfere with fracture healing in rat femora显示文摘 | Cao Y Mori S Mashiba T | | 0，，01： | 1 |
| 16 | The effects of suppressed bone remodeling by bisphosphonates on microdamage accumulation and degree of mineralization in the cortical bone of dog rib显示文摘 | Mashiba T Mori S Burr DB | 2005 | J Bone Miner Metab2005，，： | 1 |
| 17 | Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles 显示文摘 | Mashiba T Turner GH Hirano T | 2001 | Bone2001，28，5： | 1 |
| 18 | Bone remodeling at the iliac crest can predict the changes in remodeling dynamics, microdamage accumulation, and mechanical properties in the lumbar vertebrae of dogs 显示文摘 | Mashiba T Hui S Turner CH | 2005 | Calcif Tissue Int2005，77，3： | 1 |
| 19 | Bisphosphonate treatment suppresses not only stochastic remodeling but also the targeted repair of microdamage 显示文摘 | Li J Mashiba T Burr DB | 2001 | Calcif Tissue Int2001，69，5： | 1 |
| 20 | Raloxifene, estrogen, and alendronate affect the processes of fracture repair differently in ovariectomized rats显示文摘 | CAO Y MORI S MASHIBA T | 2002 | J Bone Miner Res2002，17，12： | 1 |
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