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| 1 | 肝络通对门静脉高压症大鼠肝组织α7-烟碱样乙酰胆碱受体的影响显示文摘目的:分析肝络通对门静脉高压症大鼠肝组织中α7-烟碱样乙酰胆碱受体表达的影响特征,探讨肝络通治疗门静脉高压症的可能机制。方法:取体重240~260g的清洁级雄性SD大鼠40只,根据体重随机分为假手术组、2周模型组、2周肝络通组、4周模型组、4周肝络通组。模型组及给药组采用胆总管结扎术(CBDL)对大鼠进行造模,分别于造模2周、4周测量门静脉压力,并用免疫印迹法检测α7-烟碱样乙酰胆碱受体(nAchRα7)在肝组织中的表达。结果:胆总管结扎后2周和4周门静脉压力均显著升高,模型组nAchRα7的表达较假手术组明显增多,门静脉压力和nAchRα7的表达具有随术后时间延长而加重的一致性趋势。肝络通组门静脉压力显著低于模型组,术后4周作用最为显著;2周肝络通组nAchRα7的表达与2周模型组比较无显著差异,4周肝络通组较4周模型组显著减少。结论:肝组织nAchRα7的表达变化与门静脉压力变化具有一致性趋势,肝络通降低门静脉压力的作用可能与调节肝组织内nAchRα7的表达有关。 | 姜俊杰 杜庆红 韩琳 Arezou Mashoufi 李澎涛 | 2010 | 世界科学技术-中医药现代化2010，12，3： | 3 |
| 2 | Effect of Glytan on the Expression of the Nicotinic Acetylcholine Receptor a7 in Portal Hypertensive Rats显示文摘 | Jiang Junjie Du Qinghong Han Lin Arezou Mashoufi Li Pengtao | 2010 | World Science and Technology2010，，3： | 1 |
| 3 | The Chinese herbal formula Tongluo Jiunao promotes expression of brain-derived neurotrophic factor/tropomyosin-related kinase B pathways in a rat model of ischemic brain injury显示文摘The neurotrophin-Trk receptor pathway is an intrinsic pathway to relieve damage to the central nervous system. The present study observed the effects of Tongluo Jiunao (TLJN), which comprises Panax Notoginseng and Gardenia Jasminoides, on expression of brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) in a rat model of focal cerebral ischemic injury. Xue Sai Tong (XST), comprising Panax Notoginseng, served as the positive control. Mechanisms of neuroprotection were analyzed following TLJN injection. Following establishment of the middle cerebral artery occlusion models, TLJN and XST were intraperitoneally injected, and 2, 3, 5-triphenyltetrazolium chloride staining results revealed that TLJN injection reduced infarct volume, suggesting that TLJN exerted a neuroprotective effect. Enzyme-linked immunosorbent assay results showed that TLJN elevated BDNF and growth associated protein-43 expression in ischemic brain tissues, as well as serum BDNF levels. Reverse-transcription polymerase chain reaction and western blot results showed that TLJN injection did not affect TrkB expression in the ischemic brain tissues of rats. These results suggested that TLJN injection reduced damage to ischemic brain tissues and increased BDNF expression. In addition, TLJN injection resulted in better promoting effects on neurotrophic factor expression compared with XST. | Peiman Alesheikh Huiling Tang Pengtao Li Wei Zhang Yanshu Pan Arezou Mashoufi Liyun Zhao Runjun Wang Bo Di Yangyang Yan | 2011 | Neural Regeneration Research2011，6，12： | 1 |
| 4 | Chinese herbal formula Tongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway显示文摘The Chinese herbal formula Tongluo Jiunao, containing the active components Panax notoginseng and Gardenia jasminoides, has recently been patented and is in use clinically. It is known to be neuroprotective in cerebral ischemia, but the underlying pathway remains poorly understood. In the present study, we established a rat model of cerebral ischemia by occlusion of the middle cerebral artery, and administered Tongluo Jiunao, a positive control(Xuesai Tong, containing Panax notoginseng) or saline intraperitoneally to investigate the pathway involved in the action of Tongluo Jiunao injection. 2,3,5-Triphenyltetrazolium chloride(TTC) staining showed that the cerebral infarct area was significantly smaller in model rats that received Tongluo Jiunao than in those that received saline. Enzyme-linked immunosorbent assay revealed significantly greater expression of neurotrophin 3 and growth-associated protein 43 in ischemic cerebral tissue, and serum levels of neurotrophin 3, in the Tongluo Jiunao group than in the saline group. The reverse transcription polymerase chain reaction and immunohistochemical staining showed that after treatment with Tongluo Jiunao or Xuesai Tong, tropomyosin-related kinase C gene expression and immunoreactivity were significantly elevated compared with saline, with the greatest expression observed after Tongluo Jiunao treatment. These findings suggest that Tongluo Jiunao injection exerts a neuroprotective effect in rats with cerebral ischemia by activating the neurotrophin 3/tropomyosin-related kinase C pathway. | Peiman Alesheikh Arezou Mashoufi Hui-ling Tang Wei Zhang Bo Di Yang-yang Yan Peng-tao Li Yan-shu Pan | 2015 | Neural Regeneration Research2015，10，3： | 1 |
| 5 | α1-烟碱样乙酰胆碱受体在门脉高压症发病机制中的作用分析显示文摘目的:探讨肝组织中的α1-烟碱样乙酰胆碱受体在胆汁性肝纤维化引起的门静脉高压症(PHT)发病机制中的作用。方法:取体重240-260g的清洁级雄性SD大鼠30只,根据体重随机分为假手术组、模型组。模型组采用胆总管结扎术(CBDL)对大鼠进行造模,分别于2周、4周测门静脉压力,并用免疫组化和免疫印迹法对α1-烟碱样乙酰胆碱受体(nAchRα1)进行定位及定量的检测。结果:假手术组的门静脉压力是7.97±0.55mmHg,造模后2周和4周门静脉压力升高,分别为14.15±0.92mmHg;17.75±0.86mmHg。免疫组化显示nAchRα1主要表达在肝窦和汇管区。免疫印迹显示模型组nAchRα1的表达较假手术组明显增多。结论:nAchRα1可能通过活化肝星状细胞,进而形成肝窦毛细血管化,来参与门静脉高压症的发病机制。 | 姜俊杰 杜庆红 韩琳 Arezou Mashoufi 李澎涛 | 2010 | 现代生物医学进展2010，10，6： | 0 |
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