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| 1 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 2 | Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells显示文摘 | Saiyong Zhu Raiesh Ambasudhan Woong Sun Hyun Jung Kim Maria Talantova Xiaojing Wang Mingliang Zhang Yu Zhang Timothy Laurent James Parker Han-Seop Kim Jeffrey D Zaremba Sofiyan Saleem Sara Sanz-Blasco Eliezer Masliah Scott R McKercher Yee Sook Cho Stuart A Lipton Janghwan Kim Sheng Ding | 2014 | Cell Research2014，24，1： | 6 |
| 3 | Rabeprazole test for the diagnosis of gastro-oesophageal reflux disease: Results of a study in a primary care setting显示文摘瞄准:为了决定病人的 rabeprazole 测试的诊断价值,由全科医生看。方法:有 GERD 暗示的症状的 83 个病人被全科医生在这个多中心注册,使随机化并且双窗帘学习。所有病人收到了 rabeprazole (20 mg 出价) 或安慰剂一个星期。GERD 的诊断在内视镜检查法或反常食道的 24-h pH 测试在粘膜裂缝的存在上被建立。如果病人们报导至少,“ 7 点 Likert 上的症状的清楚的改进”可伸缩,测试被认为阳性。结果:为 rabeprazole 和安慰剂的测试的敏感分别地是 83% 和 40% 。相应特性,积极、否定的预兆的价值是 45% 和 67% , 71% 和 71% ,和 62% 和 35% 分别地。操作特征(巨鸟) 分析的接收装置证实最好差别对待截止对应于对“清楚的改进”的描述。结论:禁止者(PPI ) 测试的质子泵的差的特性不支持如此的一条途径在一个主要照顾背景建立 GERD 的诊断。 | Stanislas Bruley des Varannes Sylvie Sacher-Huvelin Fabienne Vavasseur Claude Masliah Marc Le Rhun Philippe Aygalenq Sylvie Bonnot-Marlier Yves Lequeux Jean Paul Galmiche | 2006 | World Journal of Gastroenterology2006，12，16： | 4 |
| 4 | Immunoreactivity of CD45,a protein phosphotyrosine phosphatase,in Alzheimer' s disease 显示文摘 | Masliah E Mallory M Hansen L Alford M Albright T Terry R | 1991 | Acta Neuropathol( Berl )1991，83，1： | 2 |
| 5 | Neurodegenerationin the central nervous system of apoE-deficient mice显示文摘 | Masliah E Mallory M Ge N | 1995 | Exp Neurol1995，136，： | 1 |
| 6 | Profound increase in sensitivity to glutamatergic but not cholinergic agonistinduced seizures in transgenic mice with astrocyte production of IL-6显示文摘 | Samland H Huitron-Resendiz S Masliah E | 2003 | J Neurosci Res2003，73，2： | 1 |
| 7 | Synaptophysin gene expression in human brain:a quantitative in sitn hybridization and immunocytochemical study显示文摘 | Eastwood SL Burnet PWJ Masliah E | 1994 | Neuroscience1994，59，4： | 1 |
| 8 | The autophagy- related protein bcclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice显示文摘 | Piekford F Masliah E Britschgi M | 2008 | J ClinInvest2008，118，6： | 1 |
| 9 | Physical basis of cognitive alterations in Alzheimer's disease:synapse loss is the major correlate of cognitive impairment显示文摘 | Terry RD Masliah E Salmon DP | 1991 | Ann Neurol1991，30，： | 1 |
| 10 | Profound increase in sensitivity to glutamutergic but not cholinergic agonistinduced seizures in transgenic mice with astrocyte production of IL-6显示文摘 | Samland H Huitron-Resendiz S Masliah E | 2003 | J Neurosci Res2003，73，2： | 1 |
| 11 | Dopaminergic loss andinclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders显示文摘 | Masliah E Rockenstein E Veinbergs I | 2000 | Science2000，287，5456： | 1 |
| 12 | Immunohistochemical quantific-tion of the synapse-related protein synaptophysin in Alzheimer's disease显示文摘 | Masliah E Terry RD DeTeresa R | 1989 | Neurosci Lett1989，103，2： | 1 |
| 13 | HSP70 reduces α-synuclein aggregation and toxicity显示文摘 | Klucken J Shin Y Masliah E | 2004 | J Biol Chem2004，279，25： | 1 |
| 14 | Molecular mechanisms of neurodegeneration in Alzheimer's disease显示文摘 | Crews L Masliah E | 2010 | Hum Mol Genet2010，19，1： | 1 |
| 15 | High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation 显示文摘 | Mucke L Masliah E Yu GQ | 2000 | J Neurosci2000，，： | 1 |
| 16 | Physical basis of cognitive altem-ations in Alzheimer's disease:synapse loss is the major correlate of cognitive impairment显示文摘 | Terry RD Masliah E Saimon DP | 1991 | Ann Neurol1991，30，5： | 1 |
| 17 | Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease 显示文摘 | Fukushima H Masliah E | 1993 | Proc Natl Acad Sci USA1993，90，11： | 1 |
| 18 | Profound increase in sensitivity to glutamatergic but not cholinergic agonistinduced seizures in transgenic mice with astrocyte production of IL-6显示文摘 | Samland H Huitron-Resendiz S Masliah E | 2003 | J Neurosci Res2003，73，2： | 1 |
| 19 | Cyclooxygenase-2 and its role in colorectal cancer development显示文摘 | Wendum D Masliah J Trugnan G | 2004 | Virchows Arch2004，445，4： | 1 |
| 20 | β-Amyloid peptides enhance α-synuelein accumulation and neuronal deficits in atransgenic mouse model linking Alzheimer's disease and Parkinson's disease 显示文摘 | Masliah E Rockenstein E Veinbergs I | 2001 | Neurobiology2001，98，12： | 1 |
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