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| 1 | Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure显示文摘BACKGROUND Acute cardiorenal syndrome type 1(CRS-1)is defined by a rapid cardiac dysfunction leading to acute kidney injury(AKI).Neutrophil gelatinaseassociated lipocalin(NGAL)is expressed on the surface of human neutrophils and epithelial cells,such as renal tubule cells,and its serum(sNGAL)and urinary have been used to predict AKI in different clinical settings.AIM To characterize CRS-1 in a cohort of patients with acute heart diseases,evaluating the potentiality of sNGAL as an early marker of CRS-1.METHODS We performed a retrospective cohort,multi-centre study.From January 2010 to December 2011,we recruited 202 adult patients admitted to the coronary intensive care unit(CICU)with a diagnosis of acute heart failure or acute coronary syndrome.We monitored the renal function to evaluate CRS-1 development and measured sNGAL levels within 24 h and after 72 h of CICU admission.RESULTS Overall,enrolled patients were hemodynamically stable with a mean arterial pressure of 92(82-107)mmHg,55/202(27.2%)of the patients developed CRS-1,but none of them required dialysis.Neither the NGAL delta value(AUC 0.40,95%CI:0.25-0.55)nor the NGAL peak(AUC 0.45,95%CI:0.36-0.54)or NGAL cutoff(≥140 ng/mL)values were statistically significant between the two groups(CRS-1 vs no-CRS1 patients).The area under the ROC curve for the prediction of CRS-1 was 0.40(95%CI:0.25-0.55)for the delta NGAL value and 0.45(95%CI:0.36-0.54)for the NGAL peak value.Finally,in multivariate analysis,the risk of developing CRS-1 was correlated with age>60 years,urea nitrogen at admission and 24 h-urine output(AUC 0.83,SE=60.5%SP=93%),while sNGAL was not significantly correlated.CONCLUSION In our population,sNGAL does not predict CRS-1,probably as a consequence of the mild renal injury and the low severity of heart disease.So,these data might suggest that patient selection should be taken into account when considering the utility of NGAL measurement as a biomarker of kidney damage. | Fiorenza Ferrari Elisa Scalzotto Pasquale Esposito Sara Samoni Flavio Mistrorigo Lilia Maria Rizo Topete Massimo De Cal Grazia Maria Virzì Valentina Corradi Rossella Torregrossa Roberto Valle Stefania Bianzina Nadia Aspromonte Matteo Floris Alessandro Fontanelli Alessandra Brendolan Claudio Ronco | 2020 | World Journal of Clinical Cases2020，8，9： | 3 |
| 2 | Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?显示文摘AIM To evaluate the prevalence of nodular lymphoid hyperplasia(NLH) in adult patients undergoing colonoscopy and its association with known diseases. METHODS We selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome(IBS)-type symptoms or suspected inflammatory bowel disease(IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer screening.Data collection included medical history and final diagnosis. As controls, we considered all colonoscopies performed for the aforementioned indications during the same period.RESULTS One thousand and one hundred fifty colonoscopies were selected. NLH was rare in asymptomatic individuals(only 3%), while it was significantly more prevalent in symptomatic cases(32%). Among organic conditions associated with NLH, the most frequent was IBD, followed by infections and diverticular disease. Interestingly, 31% of IBS patients presented diffuse colonic NLH. NLH cases shared some distinctive clinical features among IBS patients: they were younger, more often female, and had a higher frequency of abdominal pain, bloating, diarrhoea, unspecific inflammation, self-reported lactose intolerance and metal contact dermatitis. CONCLUSION About 1/3 of patients with IBS-type symptoms or suspected IBD presented diffuse colonic NLH, which could be a marker of low-grade inflammation in a conspicuous subset of IBS patients. | Anna Chiara Piscaglia Lucrezia Laterza Valentina Cesario Viviana Gerardi Rosario Landi Loris Riccardo Lopetuso Giovanni Calò Giovanna Fabbretti Massimo Brisigotti Maria Loredana Stefanelli Antonio Gasbarrini | 2016 | World Journal of Gastroenterology2016，22，46： | 2 |
| 3 | NGAL: a biomarker of acute kidney injury and other systemic conditions显示文摘 | Sachin S. Soni Dinna Cruz Ilona Bobek Chang Yin Chionh Federico Nalesso Paolo Lentini Massimo Cal Valentina Corradi Grazia Virzi Claudio Ronco | 2010 | International Urology and Nephrology2010，，1： | 1 |
| 4 | Plasma neutrophil gelatinase-associated lipocalin is an early bio- marker for acute kidney injury in an adult ICU population 显示文摘 | Dinna Cruz Massimo Cal Francesco Garzotto | 2010 | Intensive care Med2010，36，3： | 1 |
| 5 | Effectiveness of Ibutilide in Cardioversion of Persistent Atrial Fibrillation in Patients with Dual Chamber Stimulation显示文摘 | Massimo Santini Carlo Pignalberi Renato Ricci Leonardo Calò Luca Santini | 2003 | Journal of Interventional Cardiac Electrophysiology2003，，1： | 1 |
| 6 | N-3 Fatty Acids for the Prevention of Atrial Fibrillation After Coronary Artery Bypass Surgery显示文摘 | Leonardo Calò Leopoldo Bianconi Furio Colivicchi Filippo Lamberti Maria Luisa Loricchio Ermenegildo de Ruvo Antonella Meo Claudio Pandozi Mario Staibano Massimo Santini | 2005 | Journal of the American College of Cardiology2005，，： | 1 |
| 7 | Extracorporeal Blood Purification Therapies for Prevention of Radiocontrast-Induced Nephropathy: A Systematic Review显示文摘 | Dinna N. Cruz Mark A. Perazella Rinaldo Bellomo Valentina Corradi Massimo de Cal Dingwei Kuang Catalina Ocampo Federico Nalesso Claudio Ronco | 2006 | American Journal of Kidney Diseases2006，，3： | 1 |
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