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| 1 | Antibiotic prophylaxis in variceal hemorrhage:Timing,effectiveness and Clostridium difficile rates显示文摘AIM:To investigate if antibiotics administered within 8 h of endoscopy reduce mortality or increase the incidence of Clostridium difficile infection(CDI).METHODS:A 2-year retrospective analysis of all patients who presented with first variceal hemorrhage was undertaken.The primary outcome measure was 28-d mortality.Secondary outcome measures were 28-d rebleeding rates and 28-d incidence of CDI.All patients were admitted to a tertiary liver unit with a consultantled,24-h endoscopy service.Patients received standard care including terlipressin therapy.Data collection included:primary and secondary outcome measures,timing of first administration of intravenous antibiotics,eti-ology of liver disease,demographics,endoscopy details and complications.A prospective study was undertaken to determine the incidence of CDI in the study population and general medical inpatients admitted for antibiotic therapy of at least 5 d duration.Statistical analysis was undertaken using univariate,non-parametric tests and multivariate logistic regression analysis.RESULTS:There were 70 first presentations of variceal hemorrhage during the study period.Seventy percent of cases were male and 65.7% were due to chronic alcoholic liver disease.In total,64/70(91.4%) patients received antibiotics as prophylaxis during their admission.Specifically,53/70(75.7%) received antibiotics either before endoscopy or within 8 h of endoscopy [peri-endoscopy(8 h) group],whereas 17/70(24.3%) received antibiotics at > 8 h after endoscopy or not at all(non peri-endoscopy group).Overall mortality and rebleeding rates were 13/70(18.6%) and 14/70(20%),respectively.The periendoscopy(8 h) group was significantly less likely to die compared with the non peri-endoscopy group [13.2% vs 35.3%,P = 0.04,odds ratio(OR) = 0.28(0.078-0.997)] and showed a trend towards reduced rebleeding [17.0% vs 29.4%,P = 0.27,OR = 0.49(0.14-1.74)].On univariate analysis,the non peri-endoscopy group [P = 0.02,OR = 3.58(1.00-12.81)],higher model for end-stage liver disease(MELD) score(P = 0.02),presence of hepatorenal syndrome [P < 0.01,OR = 11.25(2.24-56.42)] and suffering a clinical episode of sepsis [P = 0.03,OR = 4.03(1.11-14.58)] were significant predictors of death at 28 d.On multivariate logistic regression analysis,lower MELD score [P = 0.01,OR = 1.16(1.04-1.28)] and periendoscopy(8 h) group [P = 0.01,OR = 0.15(0.03-0.68)] were independent predictors of survival at 28 d.The CDI incidence(5.7%) was comparable to that in the general medical population(5%).CONCLUSION:Antibiotics administered up to 8 h following endoscopy were associated with improved survival at 28 d.CDI incidence was comparable to that in other patient groups. | Matthew RL Brown Graeme Jones Kathryn L Nash Mark Wright Indra Neil Guha | 2010 | World Journal of Gastroenterology2010，16，42： | 13 |
| 2 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 3 | The health benefits of selenium in food animals:a review显示文摘Selenium is an essential trace mineral important for the maintenance of homeostasis in animals and humans.It evinces a strong antioxidant,anti-inflammatory and potential antimicrobial capacity.Selenium biological function is primarily achieved by its presence in selenoproteins as a form of selenocysteine.Selenium deficiency may result in an array of health disorders,affecting many organs and systems;to prevent this,dietary supplementation,mainly in the forms of organic(i.e.,selenomethionine and selenocysteine)inorganic(i.e.,selenate and selenite)sources is used.In pigs as well as other food animals,dietary selenium supplementation has been used for improving growth performance,immune function,and meat quality.A substantial body of knowledge demonstrates that dietary selenium supplementation is positively associated with overall animal health especially due to its immunomodulatory activity and protection from oxidative damage.Selenium also possesses potential antiviral activity and this is achieved by protecting immune cells against oxidative damage and decreasing viral replication.In this review we endeavor to combine established and novel knowledge on the beneficial effects of dietary selenium supplementation,its antioxidant and immunomodulatory actions,and the putative antimicrobial effect thereof.Furthermore,our review demonstrates the gaps in knowledge pertaining to the use of selenium as an antiviral,underscoring the need for further in vivo and in vitro studies,particularly in pigs. | Brittany M.Pecoraro Diego F.Leal Alba Frias-De-Diego Matthew Browning Jack Odle Elisa Crisci | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 4 |
| 4 | Automatic Panoramic Image Stitching using Invariant Features显示文摘 | Matthew Brown David G. Lowe | 2007 | International Journal of Computer Vision2007，，1： | 3 |
| 5 | Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation显示文摘 | Xiaolei Qiu Katharine Brown Matthew D. Hirschey Eric Verdin Danica Chen | 2010 | Cell Metabolism2010，，6： | 2 |
| 6 | Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.显示文摘 | Neil Woodford Matthew J. Ellington Juliana M. Coelho Jane F. Turton M. Elaina Ward Susan Brown Sebastian G.B. Amyes David M. Livermore | 2006 | International Journal of Antimicrobial Agents2006，，4： | 2 |
| 7 | Prevention of De Novo Hepatitis B in Recipients of Core Antibody-Positive Livers With Lamivudine and Other Nucleos(t)ides: A 12-Year Experience显示文摘 | Matthew S. Chang Sonja K. Olsen Elsa M. Pichardo Jessica B. Stiles Lori Rosenthal-Cogan William D. Brubaker James V. Guarrera Jean C. Emond Robert S. Brown | 2013 | Transplantation Journal2013，，7： | 2 |
| 8 | Learning multi-label scene classification显示文摘 | Matthew R. Boutell Jiebo Luo Xipeng Shen Christopher M. Brown | 2004 | Pattern Recognition2004，，9： | 2 |
| 9 | Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer Center显示文摘 | Niraj J. Gusani MD Sung W. Cho MD Christos Colovos MD PhD Songwon Seo MS Jan Franko MD PhD Scott D. Richard MD Robert P. Edwards MD Charles K. Brown MD PhD Matthew P. Holtzman MD Herbert J. Zeh MD David L. Bartlett MD | 2008 | Annals of Surgical Oncology2008，，3： | 2 |
| 10 | Predictors of mortality and stenosis after transjugular intrahepatic portosystemic shunt显示文摘 | Mark W. Russo Paul F. Jacques Matthew Mauro Pat Odell Robert S. Brown | 2002 | Liver Transplantation2002，，3： | 2 |
| 11 | National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1 – executive summary显示文摘 | Terry A. Jacobson Matthew K. Ito Kevin C. Maki Carl E. Orringer Harold E. Bays Peter H. Jones James M. McKenney Scott M. Grundy Edward A. Gill Robert A. Wild Don P. Wilson W. Virgil Brown | 2014 | Journal of Clinical Lipidology2014，，： | 2 |
| 12 | Regression of Inflammation in Atherosclerosis by the LXR Agonist R211945显示文摘 | Esad Vucic Claudia Calcagno Stephen D. Dickson James H.F. Rudd Katsumi Hayashi Jan Bucerius Erin Moshier Jessica S. Mounessa Michelle Roytman Matthew J. Moon James Lin Sarayu Ramachandran Tatsuo Tanimoto Karen Brown Masakatsu Kotsuma Sotirios Tsimikas Edw | 2012 | JACC: Cardiovascular Imaging2012，，8： | 2 |
| 13 | Determining the concentration of CuInS2 quantum dots from the size-dependent molar extinction coefficient显示文摘 | Matthew Booth Andrew P Brown Stephen D Evans | | 0，，： | 1 |
| 14 | Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects 显示文摘 | Matthews R T Yang L Browne S | 1998 | Proc Natl Acad Sci U S A1998，95，15： | 1 |
| 15 | Transmembrane semaphorin5B is proteolytically processed into a repulsive neural guidance cue显示文摘 | Kristen Browne Wenyan Wang Rachel Q. Liu Matthew Piva Timothy P. O’Connor | 2012 | Journal of Neurochemistry2012，，： | 1 |
| 16 | Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer Center显示文摘 | Niraj J. Gusani Sung W. Cho Christos Colovos Songwon Seo Jan Franko Scott D. Richard Robert P. Edwards Charles K. Brown Matthew P. Holtzman Herbert J. Zeh David L. Bartlett | 2008 | Annals of Surgical Oncology2008，，3： | 1 |
| 17 | Estimating the environmental costs of soil erosion at multiple scales in Kenya using emergy synthesis 显示文摘 | Matthew J Cohen Mark T Brown Keith D Shepherd | 2006 | Agriculture Ecosystems and Environment2006，114，2： | 1 |
| 18 | Automatic Panoramic Image Stitching using Invariant Features显示文摘 | Matthew Brown David G. Lowe | 2007 | International Journal of Computer Vision2007，，1： | 1 |
| 19 | Five Years of GWAS Discovery显示文摘 | Peter M. Visscher Matthew A. Brown Mark I. McCarthy Jian Yang | 2012 | The American Journal of Human Genetics2012，，1： | 1 |
| 20 | Automatic panoramic image stitching using invariant features显示文摘 | Matthew Brown David G Lowe | 2007 | International Journal of Computer Vision2007，74，1： | 1 |
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