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| 1 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 2 | Acute ischaemic stroke interventions: large vessel occlusion and beyond显示文摘Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical thrombectomy.Large vessel occlusion(LVO)accounts for up to 38%of acute ischaemic stroke and comes with devastating outcomes for patients,families and society in the pre-intervention era.A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke;this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming benefits.This review article will present a comprehensive overview of LVO management,techniques and devices used,and the future of stroke therapy.In addition,we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion. | Ahmad Sweid Batoul Hammoud Sunidhi Ramesh Daniella Wong Tyler D Alexander Joshua Harrison Weinberg Maureen Deprince Jaime Dougherty Dimitri Jean-Mickael Maamari Stavropoula Tjoumakaris Hekmat Zarzour Michael R Gooch Nabeel Herial Victor Romo David M Hasan Robert H Rosenwasser Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 2 |
| 3 | Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study显示文摘 | Douglas S Berkman Andres G Lescano Robert H Gilman Sonia L Lopez Maureen M Black | 2002 | The Lancet2002，，9306： | 1 |
| 4 | Effect of textile properties in evalu- ating a directional shading fabric 显示文摘 | MAUREEN M G BRUCE D H ARDIS M R | 1997 | Textile Research Journal1997，67，4： | 1 |
| 5 | Gamma linolenic acid attenuates cardiovascuar responses to stress in borderline hypertensive rats 显示文摘 | David E M Maureen R S | 1985 | Lipids1985，20，9： | 1 |
| 6 | Nonlinear control ofvariable-speed wind turbines for generator torque limiting and poweroptimization显示文摘 | Boukhezzar B Siguerdidjane H Maureen H M | 2006 | ASME Transactions on Journal of Solar EnergyEngineering2006，128，4： | 1 |
| 7 | Connective tissue growth factor(CTGF/CCN2)negatively regulates BMP-2 induced osteoblast differentiation and signaling显示文摘 | Christina M Maureen G Steven NP | 2014 | J Cell Physiol2014，229，5： | 1 |
| 8 | Anemia in pregnancy显示文摘 | Alfred Ian Lee Maureen M et al | 2011 | Hematology/oncology clinics of North America2011，25，2： | 1 |
| 9 | Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial显示文摘 | Marc Decramer Maureen Rutten-van M?lken PN Richard Dekhuijzen Thierry Troosters Cees van Herwaarden Riccardo Pellegrino CP Onno van Schayck Dario Olivieri Mario Del Donno Wilfried De Backer Ida Lankhorst Alfredo Ardia | 2005 | The Lancet2005，，9470： | 1 |
| 10 | Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies显示文摘 | MAUREEN G M WALTER J S JOHN D G | 1994 | Ophthalmology1994，101，： | 1 |
| 11 | Relationship of physical symptoms mad physical functioning to depression patients with heart failure 显示文摘 | Maureen M | 2000 | Heart mad Lung2000，30，2： | 1 |
| 12 | Shipping charges and shipping charge skepticism: implications for direct marketers pricing format 显示文摘 | Schindler R M Maureen M Nada N B | 2005 | Journal of Interactive Marketing2005，，1： | 1 |
| 13 | Rapid high-performance liquid chromatography method for the analysis of sodium benzoate and potassium sorbate in foods显示文摘 | Harry M Pylypiw Jr Maureen T Grether | 2000 | Journal of Chromatograhpy A2000，883，： | 1 |
| 14 | Cytotoxic T Lymphocyte Antigen–4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis显示文摘 | Nicole M. F. Gerven Ynto S. Boer Antonie Zwiers Bart Hoek Karel J. Erpecum Ulrich Beuers Henk R. Buuren Joost P. H. Drenth Jannie W. den Ouden Robert C. Verdonk Ger H. Koek Johannes T. Brouwer Maureen M. J. Guichelaar Jan M. Vrolijk G. Kraal Chris J. J. M | 2013 | Liver Int2013，，7： | 1 |
| 15 | EGFR gene mutationsare common in lung cancers from 'Never smokers' and are associated with Sensitivity of tumors to gefitinib and erltinib显示文摘 | Vincent M Maureen Z | 2004 | Proc Nati Acad Sci2004，101，13： | 1 |
| 16 | Flucon_ azole therapy in transplant recipients receiving FK506 显示文摘 | Manoz R Maureen M Venkatramanan R | 1994 | Transplantation1994，57，： | 1 |
| 17 | Avifauna of the Gaoligong Shan Mountains of western China: a hotspot of avian species diversity显示文摘 | John P D Jeremy M Maureen E | 2010 | Or- nithological Monographs2010，70，： | 1 |
| 18 | Nasogastric feeding for stroke patients : practice and education 显示文摘 | Catherine M Anne R Maureen M | 2015 | Br J Nurs2015，24，6： | 1 |
| 19 | Cost Effectiveness of Pharmacological Maintenance Treatment for Chronic Obstructive Pulmonary Disease显示文摘 | Maureen P.M.H. Rutten-van M?lken Lucas M.A. Goossens | 2012 | PharmacoEconomics2012，，4： | 1 |
| 20 | Information and the coat of capital显示文摘 | Easley Maureen O'Hara M | 2004 | Journal of Finance2004，59，4： | 1 |
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