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| 1 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 2 | Identification of neutral- izing conformational epitopes on the human papillomavirus type 31 major eapsid protein and functional implications 显示文摘 | Fleury MJ Touze A Maurel MC et cd | 2009 | Protein Sci2009，18，7： | 1 |
| 3 | EPIC:PhaseⅢtrial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer显示文摘 | Sobrero A F Maurel J Fehrenbacher L | 2008 | J Clin Oncol2008，26，14： | 1 |
| 4 | Inflammatory bowel disease and pregnancy: report of 76 cases and review of the literature显示文摘 | Beniada A Benoist G Maurel J | 2005 | J Gynecol Obstet Biol Reprod (Paris)2005，34，6： | 1 |
| 5 | Mesenchymal stem cell therapy regenerates the native bone-tendon junction after surgical repair in a degenerative rat model显示文摘 | Nourissat G Diop A Maurel N | | 0，，08： | 1 |
| 6 | How does drought tolerance compare between two improved hybrids of balsam poplar and an unimproved native species 显示文摘 | Larcheveque M Maurel M Desrochers A | 2011 | Tree Physiology2011，31，5： | 1 |
| 7 | EPIC: phase Ⅲ trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer 显示文摘 | Sobrero A F Maurel J Fehrenbacher L | 2008 | J Clin Oncol2008，26，14： | 1 |
| 8 | Randomized phase II study comparing gemcitabine plus dacarbazine versus dacarbazine alone in patients with previously treated soft tissue sarcoma:a Spanish Group for Research on Sarcomas study显示文摘 | Garcia-Del-Muro X Lopez-Pousa A Maurel J | | 0，，： | 1 |
| 9 | Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27显示文摘 | LANNEAU D DE THONEL A MAUREL S | 2007 | Prion2007，1，1： | 1 |
| 10 | Plant aquaporins:their molecular biology,biophysics and significance for plant water relations显示文摘 | TYERMAN S D BOHNERT H J MAUREL C STEUDLE E SMITH J A C | 1999 | Journal of Experimental Botany1999，50，： | 1 |
| 11 | Plant aquaporins: Their molecular biology, biophysics and significance for plant water relations显示文摘 | TYERMAN S D BOHNERT H J MAUREL C STEUDLE E SMITH J A C | 1999 | Journal of Experimental Botany1999，50，： | 1 |
| 12 | Hesperidine, a flavonoid antioxidant decrease oxidative stress and prevent foetal molformations in experimental diabetic pregnancy显示文摘 | OUALI K TREA F TOUMI L BAIRI A MAUREL D GUELLATI M A | 2007 | Phytotherapie ( Paris )2007，5，4： | 1 |
| 13 | Apoptosis versus cell differentiation : role of heat shock proteins HSP90, HSP70 and HSP27 显示文摘 | Lanneau D de Thonel A Maurel S | 2007 | Prion2007，1，1： | 1 |
| 14 | Age-dependent increase in hydrogen peroxide production by cardiac monoamine oxidase A in rats显示文摘 | MAUREL A HERNANDEZ C KUNDUZOVA O | 2003 | Am J Physiol2003，284，： | 1 |
| 15 | A look inside: localiza- tion patterns and functions of intracellular plant aquaporins 显示文摘 | Wudick M M Luu D T Maurel C A | 2009 | New Phytologist2009，184，2： | 1 |
| 16 | In vitro studies of the effect of buflomedil on platelet responsiveness显示文摘 | Maurel A Marguerie G | 1990 | Haemostasis1990，20，： | 1 |
| 17 | A measure of the geogcaphic concentration in French manufacturing industries 显示文摘 | Maurel F dillot A | 1999 | Regional Science and Urban Economics1999，29，： | 1 |
| 18 | Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican 显示文摘 | Milev P Maurel P Chiba A | 1998 | Biochem Biophys Res Commun1998，247，2： | 1 |
| 19 | EPIC:Phase Ⅲ trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer显示文摘 | Sobrero A F Maurel J Fehrenbacher L | 2008 | J Clin Oncol2008，26，14： | 1 |
| 20 | Experimental and theoretical inspection of thephase-to-height relation in Fourier transform profilometry 显示文摘 | MAUREL A COBELLI P PAGNEUX V | 2009 | Applied Optics2009，48，2： | 1 |
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