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| 1 | Hypoxia,angiogenesis and liver fibrogenesis in the progression of chronic liver diseases显示文摘Angiogenesis is a dynamic,hypoxia-stimulated and growth factor-dependent process,and is currently referred to as the formation of new vessels from preexisting blood vessels.Experimental and clinical studies have unequivocally reported that hepatic angiogenesis,irrespective of aetiology,occurs in conditions of chronic liver diseases(CLDs) characterized by perpetuation of cell injury and death,inflammatory response and progressive fibrogenesis.Angiogenesis and related changes in liver vascular architecture,that in turn concur to increase vascular resistance and portal hypertension and to decrease parenchymal perfusion,have been proposed to favour fibrogenic progression of the disease towards the end-point of cirrhosis.Moreover,hepatic angiogenesis has also been proposed to modulate the genesis of portal-systemic shunts and increase splanchnic blood flow,thus potentially affecting complications of cirrhosis.Hepatic angiogenesis is also crucial for the growth and progression of hepatocellular carcinoma.Recent literature has identified a number of cellular and molecular mechanisms governing the cross-talk between angiogenesis and fibrogenesis,with a specifi c emphasis on the crucial role of hypoxic conditions and hepatic stellate cells,particularly when activated to the myofibroblast-like pro-fibrogenic.Experimental anti-angiogenic therapy has been proven to be effective in limiting the progression of CLDs in animal models.From a clinical point of view,anti-angiogenic therapy is currently emerging as a new pharmacologic intervention in patients with advanced fibrosis and cirrhosis. | Claudia Paternostro Ezio David Erica Novo Maurizio Parola | 2010 | World Journal of Gastroenterology2010，16，3： | 23 |
| 2 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 3 | Proangiogenic Cytokines as Hypoxia-Dependent Factors Stimulating Migration of Human Hepatic Stellate Cells显示文摘 | Erica Novo Stefania Cannito Elena Zamara Lorenzo Valfrè di Bonzo Alessandra Caligiuri Carlo Cravanzola Alessandra Compagnone Sebastiano Colombatto Fabio Marra Massimo Pinzani Maurizio Parola | 2007 | The American Journal of Pathology2007，，6： | 6 |
| 4 | Cellular and molecular mechanisms in liver fibrogenesis显示文摘 | Erica Novo Stefania Cannito Claudia Paternostro Claudia Bocca Antonella Miglietta Maurizio Parola | 2013 | Archives of Biochemistry and Biophysics2013，，： | 2 |
| 5 | Oxidative stress-related molecules and liver fibrosis显示文摘 | Maurizio Parola Gaia Robino | 2001 | Journal of Hepatology2001，，2： | 1 |
| 6 | Stem cells in liver failure显示文摘 | Francesco P. Russo Maurizio Parola | 2012 | Best Practice & Research Clinical Gastroenterology2012，，1： | 1 |
| 7 | Stem and progenitor cells in liver regeneration and repair显示文摘 | Francesco Paolo Russo Maurizio Parola | 2011 | Cytotherapy2011，，2： | 1 |
| 8 | Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats显示文摘 | Cecilia Grappone Massimo Pinzani Maurizio Parola Giulia Pellegrini Alessandra Caligiuri Raffaella DeFranco Fabio Marra Hermann Herbst Gianfranco Alpini Stefano Milani | 1999 | Journal of Hepatology1999，，1： | 1 |
| 9 | Oxidative damage and fibrogenesis显示文摘 | Giuseppe Poli Maurizio Parola | 1996 | Free Radical Biology and Medicine1996，，1： | 1 |
| 10 | Liver fibrogenic cells显示文摘 | Stuart J. Forbes Maurizio Parola | 2011 | Best Practice & Research Clinical Gastroenterology2011，，2： | 1 |
| 11 | Liver fibrogenic cells显示文摘 | Stuart J. Forbes Maurizio Parola | 2011 | Best Practice & Research Clinical Gastroenterology2011，，2： | 1 |
| 12 | Stem and progenitor cells in liver regeneration and repair显示文摘 | Francesco Paolo Russo Maurizio Parola | 2011 | Cytotherapy2011，，2： | 1 |
| 13 | Stem cells in liver failure显示文摘 | Francesco P. Russo Maurizio Parola | 2012 | Best Practice & Research Clinical Gastroenterology2012，，1： | 1 |
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