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| 1 | Diet,obesity and reflux in the etiology of adenocarcinomas of the esophagus and gastric cardia in humans显示文摘 | MAYNE S T NAVARRO S A | 2002 | J Nutr2002，132，11： | 1 |
| 2 | Nutrient intake and risk of subtypes of esophageal and gastric cancer显示文摘 | Susan T Mayne 2 Harvey A Risch Robert Dubrow | 2001 | Cancer Epidemiol Biomarkers Prey2001，10，10： | 1 |
| 3 | Nutrient intake and risk of subtypes of esophageal and gastric cancer显示文摘 | MAYNE S T RISCH H A DUBROW R | 2001 | Cancer Epidemiol Biomark Prev2001，10，10： | 1 |
| 4 | Nutrient intake and risk of subtypes of esophageal and gastric cancer 显示文摘 | Mayne S T Riseh H A Dubrow R | 2001 | Cancer Epidemiology Biomarkers & Pre- vention2001，10，： | 1 |
| 5 | Antioxidant nutrients and chronic disease:use of biomarkers of exposure and oxidative stress status in epidemiologic research显示文摘 | Mayne S T | 2003 | J Nutr2003，133，3： | 1 |
| 6 | Nutrient intake and risk of subtypes of esophageal and gastric cancer显示文摘 | Mayne S T Risch H A Dubrow R | 2001 | Cancer Epidemiol Biomarkers Prev2001，10，65： | 1 |
| 7 | Use of hair coloring products and breast cancer risk:a case-control study in connecticut显示文摘 | Holford TR Mayne ST | 2002 | Eur J Cancer2002，38，12： | 1 |
| 8 | Plasma PCSK9 levels are significantly modified by statins and fibrates in humans显示文摘 | Mayne J Dewpura T Raymond A | 2008 | Lipids Health Dis2008，7，22： | 1 |
| 9 | Speaking more broadly: An examination of the nature, antecedents, and consequences of an expanded set of employee voice behaviors显示文摘 | Maynes T D PodsakoffP M | 2014 | Journal of Applied Psychology2014，99，1： | 1 |
| 10 | Antioxidant nutrients and chronic disease:use of biomarkers of exposure and oxidantive stress status in epi- demiologic research显示文摘 | MAYNE S T | | 0，，03： | 1 |
| 11 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 12 | β-Benzene hexachloride in breast adipose tissue and risk of breast carcinoma显示文摘 | ZHENG T HOLFORD TR MAYNE ST | 1999 | Cancer1999，85，10： | 1 |
| 13 | Dietary fat intake and risk of pancreatic cancer in the Prostate,Lung,Colorectal and Ovarian Cancer Screening Trial显示文摘 | AREM H MAYNE S T SAMPSON J | 2013 | Ann Epidemiol2013，23，9： | 1 |
| 14 | Macular pigment in donor eyes with and without AMD:a case-control study显示文摘 | BONE R A LANDRUM J T MAYNE S T | 2001 | Invest Ophthalmol Via Sci2001，42，： | 1 |
| 15 | Dietary betacarotene and lung cancer risk in US nonsmokers显示文摘 | MAYNE S T JANERICH D T GREENWALD P | 1994 | J Natl Cancer Inst1994，86，： | 1 |
| 16 | Nutrient intake and risk of subtypes of esophageal and gastric cancer 显示文摘 | MAYNE S T RISCH H A DUBROW R | 2001 | Cancer Epidmiology Biomarkers and Prevention2001，10，10： | 1 |
| 17 | Reliability and validity of a modified brief pain inventory short form in patients with osteoarthritis显示文摘 | Mendoza T Mayne T Rublee D | 2006 | European Journal of Pain2006，10，： | 1 |
| 18 | Effects of message, source, and context on evaluations of employee voice behavior显示文摘 | Whiting S W Maynes T D PodsakoffN P | 2012 | Journal of Applied Psychology2012，97，1： | 1 |
| 19 | Antioxidant nutrients and chronic disease:use of biomarkers of exposure and oxidative stress status in epidemiologic research显示文摘 | MAYNE S T | 2003 | Journal of Nutrition2003，133，3： | 1 |
| 20 | Nutrient intake and risk if subtypes of esophageal and gastric cancer显示文摘 | Mayne S T Risch H A Dubrow R | 2001 | Cancer Epidemiol Biomarkers Prey2001，10，10： | 1 |
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