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| 1 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 2 | Transplantation of adipose derived stromai cells is associated with functional improvement in a rat model of chronic myocardial infarction显示文摘 | Mazo M Planat-benard V Abizanda G | 2008 | Eur J Heart Fail2008，10，5： | 1 |
| 3 | Postoperative pulmonary complications 显示文摘 | Canet J Mazo V | 2010 | Minerva Anestesiol2010，76，2： | 1 |
| 4 | Transplantation of adi?pose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction显示文摘 | Mazo M Planat-Benard V Abizanda G | 2008 | EurJ Heart Fail2008，10，5： | 1 |
| 5 | Postoperative pulmonary complications 显示文摘 | Canet J Mazo V | 2010 | Minerva Anestesiol2010，76，2： | 1 |
| 6 | Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction 显示文摘 | Mazo M Planat-benard V Abizanda G | 2008 | Eur J Heart Fail2008，10，5： | 1 |
| 7 | Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction显示文摘 | Mazo M Planat-Bénard V Abizanda G | | 0，，05： | 1 |
| 8 | Transplantation of ad-ipose derived stromal cells is associated with functional improvementin a rat model of chromis myocardial infarction显示文摘 | Mazo M Planat-Benard V Abizanda G | 2008 | Eur J HeartFail2008，10，5： | 1 |
| 9 | Analysis of cytokines in Seminal plasma and blood sera of patients with chronic prostatitis during immunotherapy with natural complex of cytokines and antimicrobial peptides显示文摘 | KOVAL'CHUN L V GANKOVSKAIA L V MAZO E B | 2007 | Zh Mikrobiol Epidemiol Immunobiol2007，，5： | 1 |
| 10 | Postoperative pulmonary complications显示文摘 | Canet J Mazo V | 2010 | Miner- va Anestesiol2010，76，2： | 1 |
| 11 | Disruption of six novel ORFs from Saccharomyces cerevisiae chromosome VII and phenotypic analysis of the deletants显示文摘 | Escribano M V MazońM J | | 0，，： | 1 |
| 12 | Postoperative pulmonary complications显示文摘 | Caner J Mazo V | 2010 | Minerva Anestesiol2010，76，2： | 1 |
| 13 | Thermal Expansion Coefficient in Simple Models of Condensed Matter显示文摘 | Berlin Al Al Gendelman O V Mazo M A | 2004 | Doklady Akademii Nauk2004，397，6： | 1 |
| 14 | Etiotropic therapy of chronic bacterial prostatitis显示文摘 | Popov S V Mazo E B | 2008 | Urologiia2008，，3： | 1 |
| 15 | Prospective external valida- tion of a predictive score for postoperative pulmonary complications 显示文摘 | MAZO V SABATE S CANET J | 2014 | Anesthesiology2014，121，2： | 1 |
| 16 | Postoperative pulmonary complications显示文摘 | Canet J Mazo V | 2010 | Minerva Anestesiol2010，76，2： | 1 |
| 17 | Postoperative pulmonary complications显示文摘 | Canet J Mazo V | 2010 | Minerva Anestesiol2010，76，： | 1 |
| 18 | The use of the holmium laser for treating strictures of the urethra and bladder neck in men显示文摘 | Mazo EB Chepuro V AK Plaatin LA | 1996 | Urol Nefrol (abstr act)1996，5，1： | 1 |
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