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| 1 | The expression of Spodoptera exigua P450 and UGT genes: tissue specificity and response to insecticides显示文摘Cytochrome P450 and UDP-glucosyltransferase (UGT) as phase I and phase II metabolism enzymes, respectively, play vital roles in the breakdown of endobiotics and xenobiotics. Insects can in crease the expression of detoxificatio n enzymes to cope with the stress from xenobiotics including insecticides. However, the molecular mechanisms for insecticide detoxification in Spodoptera exigua remain elusive, and the genes conferring insecticide metabolisms in this species are less well reported. In this study, 68 P450 and 32 UGT genes were identified. Phylogenetic analysis showed gene expansions in CYP3 and CYP4 clans of P450 genes and UGT33 family of this pest. P450 and UGT genes exhibited specific tissue expression patterns. Insecticide treatments in fat body cells of S. exigua revealed that the expression levels of P450 and UGT genes were significantly influenced by challenges of abamectin, lambda-cyhalothrin, chlorantraniliprole, metaflumizone and indoxacarb. Multiple genes for detoxification were affected in expression levels after insecticide exposures. The results demonstrated that lambda-cyhalothrin, chlorantraniliprole, metaflumizone and indoxacarb induced similar responses in the expression of P450 and UGT genes in fat body cells;eight P450 genes and four UGT genes were co-up-regulated significantly, and no or only a few CYP/UGT genes were down-regulated significantly by these four insecticides. However, abamectin triggered a distinct response for P450 and UGT gene expression;more P450 and UGT genes were down-regulated by abamectin than by the other four compounds. In con elusion, P450 and UGT genes from S. exigua were identified, and different responses to abamectin suggest a different mechanism for insecticide detoxification. | Bo Hu Shu-Heng Zhang Miao-Miao Ren Xiang-Rui Tian Qi Wei David Kibe Mburu Jian-Ya Su | 2019 | Insect Science2019，26，2： | 4 |
| 2 | Studies on the physiological effects of viruses on sweet potato yield in Kenya 显示文摘 | Njeru R W Mburu M W K Cheramgoi E | 2004 | Annals of Applied Biology2004，145，1： | 1 |
| 3 | Assessment of planning target volume margins for intensity-modulated radiotherapy of the prostate gland : role of daily interand intrafraction motion 显示文摘 | Tanyi JA He T Summers PA Mburu RG | 2010 | Int J Radiat Oneol Biol Phys2010，78，5： | 1 |
| 4 | Mutations in the myosin VI-IA gene cause non-syndromic recessive deafness显示文摘 | Liu XZ Walsh J Mburu P | | 0，，： | 1 |
| 5 | Psychiatric morbidity among leprosy patients in Teso and Busia districts of Western Kenya显示文摘 | Kisivuli AJ Othieno CJ Mburu JM | 2005 | East Afr Med J2005，82，9： | 1 |
| 6 | Quiet as a mouse: Dissecting the molecular and genetic basis of hearing 显示文摘 | Brown SD Hardisty--Hughes RE Mburu P | 2008 | Nat Rev Genet2008，9，： | 1 |
| 7 | Effects of organic andinorganic fertilization on soil bacterial and fungal microbial diversity inthe Kabete long - term trial, Kenya显示文摘 | Kamma M Mburu H Blanchart E | 2011 | Biology and fertility of soils2011，47，： | 1 |
| 8 | Studies on the physiological effects of viruses on sweet potatoyield in Kenya 显示文摘 | NJERU R W MBURU M W K CHERAMGORI E | 2004 | Ann Appl Biol2004，145，： | 1 |
| 9 | Resisting andchallenging stigma in Uganda : the role of supportgroups of people living with HIV显示文摘 | Mburu G Ram M Skovdal M | 2013 | J Int AIDS Soc2013，16，3： | 1 |
| 10 | CCR7 mediates inflammation-associated tumor progression显示文摘 | Mburu YK Wang J Wood MA | 2006 | Immunol Res2006，36，13： | 1 |
| 11 | Relative Importance and Determinants of Landowners' Transaction Costs in Collaborative Wildlife Management in Kenya: An Empirical Analysis 显示文摘 | JOHN MBURU REGINA BIRNER MANFRED ZELLER | 2003 | Ecological Economies2003，45，1： | 1 |
| 12 | Changes in serum levels of vitamin BI2, feed intake, liveweight and hematological parameters in cobalt deficient small east African goats 显示文摘 | MBURU J N KAMAU J M BADAMANA M S | 1992 | International Journal for Vitamin and Nutrition Research1992，63，2： | 1 |
| 13 | Defective NF-KB signaling in metastatic head and neck cancer cells leads to enhanced apoptosis by double-stranded RNA显示文摘 | Umemura N Zhu J Mburu YK | 2012 | Cancer Res2012，72，1： | 1 |
| 14 | CCR7 mediates inflammation-associated tumor progression显示文摘 | MBURU Y K WANG J WOOD M A | 2006 | Immunol Res2006，36，： | 1 |
| 15 | Changes in serum levels of vitamin B12, feed intake, live weight and hematological parameters in cobalt deficient small east African goats显示文摘 | Mburu J N Kamau M Z Badamana M S | 1993 | Int J Vitam Nutr Res1993，63，2： | 1 |
| 16 | Mutations in the myosin VIIA gene cause non-syndromic recessive deafness显示文摘 | Liu XZ Walsh J Mburu P | 1997 | Nat Genet1997，16，2： | 1 |
| 17 | Changes in serum levels of vitamin B12, feed intake, live weight and hematological parameters in cobalt deficient small east African goats显示文摘 | Mburu J N Kamau M Z Badamana M S | 1993 | Int J Vitam Nutr Res1993，63，： | 1 |
| 18 | Application of New World Camelidae microsateliite primers for amplification of polymorphic loci in Old World camelids显示文摘 | Jianlin H Mburu D Oehieng J | 2000 | Animal Genetics2000，31，： | 1 |
| 19 | Human beta-defensin 3 promotes NF-kappaB- mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck显示文摘 | Mburu YK | 2011 | Carcinogenesis2011，32，2： | 1 |
| 20 | Genetic diversity and relationships of indigenous Kenyan dromedary (Camelus dromedarius) populations: Implications for their classification显示文摘 | Mburu D N Ochieng J W Kuria S G | 2003 | Animal Genetics2003，34，1： | 1 |
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