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| 1 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 2 | Evaluation of the activity of 17450 enzymes in rats:use of the single marker or combined drug administration显示文摘 | JURICA J KYR M McCASKEY | 2009 | Neuro Endocrinol Lett2009，30，1： | 1 |
| 3 | 查看详情显示文摘 | McCaskey T A Zhou S D Britts N | | 0，，： | 1 |
| 4 | Influence of processing schemes on indicative bacteria and quality of fresh aquacultured catfish fillets显示文摘 | Fernandes F Flick JR Silva JL Mccaskey TA | 1997 | Journal of food protection1997，60，： | 1 |
| 5 | Supplemental shade for dairy calves reared in commercial calf hutches in a southern climate 显示文摘 | Coleman D A Moss B R McCaskey T A | 1996 | Journal of Dairy Science1996，79，20： | 1 |
| 6 | Effect of components of acidhydrolysed hardwood on conversion of oxylose to 2,3-butanediol by Kicbsiella pneumoniae显示文摘 | Frazer E R McCaskey T A | 1991 | Enzyme Mierobiol Technol1991，13，： | 1 |
| 7 | Effects of proprioceptive exercises on pain and function in chronic neck-and low back pain rehabilitation: a systematic literature review 显示文摘 | McCaskey MA1 Schuster-Amft C Wirth B | 2014 | BMC Musculoskelet Disord2014，15，1： | 1 |
| 8 | Effect of components of acid-hydrolysed hardwood on conversion of D-xylose to 2,3-butanediol by Klebsiella pneumoniae显示文摘 | McCaskey T A | 1991 | Enzyme Microb Technol1991，13，： | 1 |
| 9 | Effect of components of acid-hydrolysed hardwood on conversion of D-xylose to 2,3-butanediol by Klebsiella pneumoniae显示文摘 | McCaskey T A | 1991 | Enzyme Microb Technol1991，13，： | 1 |
| 10 | Effect of components of acid-hydrolysed hardwood on conversion of D-xylose to 2,3-butanediol by Klebsiella pneumoniae 显示文摘 | Frazer F R McCaskey T A | 1991 | Enzyme and Microbial Technology1991，13，2： | 1 |
| 11 | Analysis of functional response design experiments 显示文摘 | MCCASKEY S D TSUI K L | 1997 | International Journal of Quality Tech- nology1997，35，6： | 1 |
| 12 | Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis 显示文摘 | Woodworth HL McCaskey SJ Duriancik DM | 2010 | Cancer Res2010，70，20： | 1 |
| 13 | Lactic acid fermentation of food waste for swine feed显示文摘 | S.Y. Yang K.S. Ji Y.H. Baik W.S. Kwak T.A. McCaskey | 2005 | Bioresource Technology2005，，15： | 1 |
| 14 | Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration显示文摘 | Jurica J Kyr M McCaskey Hadasova E | 2009 | Neuro Endocri- nol Lett2009，30，1： | 1 |
| 15 | Die tary fish oil alters T lymphocyte cell populations and ex- acerbates disease in a mouse model of inflammatory colitis 显示文摘 | Woodworth HL McCaskey SJ Duriancik DM | 2010 | Cancer Res2010，70，20： | 1 |
| 16 | Cellulose digesti- bility of fibrous materials treated with Tricboderma viride cellulase 显示文摘 | AUTERY K M McCASKEY T A LITYLE J A | 1975 | Journal of Dairy Science1975，58，1： | 1 |
| 17 | Analysis of dynamic robust design experiments显示文摘 | McCaskey S D Tsui K L | 1997 | International Journal of Production Research1997，35，6： | 1 |
| 18 | Effect of selected components of acid-hydrolysed hardwood on conversion of D-xylose to 2,3-butanediol by KlebsieIla pneumoniae显示文摘 | Frazer F R McCaskey T A | 1991 | Enzyme and Microbial Technology1991，13，2： | 1 |
| 19 | Influence ~ff processing schemes on indicative bacteria and quality of fresh aquacultured cat-fish fillets显示文摘 | FERNANDES F FLICK J R SILVA J L MCCASKEY T A | 1997 | Journal of food protection1997，60，： | 1 |
| 20 | Differential effects of energy balance on experimentally-induced colitis显示文摘AIM:To characterize the influence of diet-induced changes in body fat on colitis severity in SMAD3-/mice.METHODS:SMAD3-/-mice (6-8 wk of age) were randomly assigned to receive a calorie restricted (30% of control;CR),control (CON),or high fat (HF) diet for 20 wk and were gavaged with sterile broth or with Helicobacter hepaticus (H.hepaticus) to induce colitis.Four weeks after infection,mice were sacrificed and the cecum and colons were processed for histological evaluation.RESULTS:Dietary treatment significantly influenced body composition prior to infection (P < 0.05),with CR mice having less (14% ± 2%) and HF-fed mice more body fat (32% ± 7%) compared to controls (22% ±4%).Differences in body composition were associated with alterations in plasma levels of leptin (HF > CON > CR) and adiponectin (CON > HF ≥ CR) (P < 0.05).There were no significant differences in colitis scores between CON and HF-fed mice 4 wk post-infection.Consistent with this,differences in proliferation and inflammation markers (COX-2,iNOS),and infiltrating cell types (CD3 + T lymphocytes,macrophages) were not observed.Unexpectedly,only 40% of CR mice survived infection with H.hepaticus,with mortality observed as early as 1 wk following induction of colitis. | Sarah J McCaskey Elizabeth A Rondini Ingeborg M Langohr Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，7： | 0 |
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