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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Current practices and future prospects for the management of gallbladder polyps: A topical review显示文摘A gallbladder polyp is an elevation of the gallbladder mucosa that protrudes into the gallbladder lumen. Gallbladder polyps have an estimated prevalence in adults of between 0.3%-12.3%. However, only 5% of polyps are considered to be 'true' gallbladder polyps, meaning that they are malignant or have malignant potential. The main radiological modality used for diagnosing and surveilling gallbladder polyps is transabdominal ultrasonography. However, evidence shows that other modalities such as endoscopic ultrasound may improve diagnostic accuracy. These are discussed in turn during the course of this review. Current guidelines recommend cholecystectomy for gallbladder polyps sized 10 mm and greater, although this threshold is lowered when other risk factors are identified. The evidence behind this practice is relatively low quality. This review identifies current gaps in the available evidence and highlights the necessity for further research to enable better decision making regarding which patients should undergo cholecystectomy, and/or radiological follow-up. | R Stephen McCain Anna Diamond Claire Jones Helen G Coleman | 2018 | World Journal of Gastroenterology2018，24，26： | 25 |
| 3 | Rapid prototyping technology for surgeries of the pediatric spine and pelvis:benefits analysis显示文摘 | Guarino J Tennyson S McCain G | 2007 | Pediatric Orthopaedic2007，27，8： | 1 |
| 4 | Legacy tourism: The search for personal meaning in heritage travel 显示文摘 | Mccain G Ray N M | 2003 | Tourism Management2003，24，6： | 1 |
| 5 | Rapid prototyping technology for surgeries of the pediatric spine and pelvis:benefits analysis显示文摘 | Guarino J Tennyson S McCain G | | 0，，08： | 1 |
| 6 | Rapid prototyping technology for surgeries of the pediatric spine and pelvis:benefits analysis显示文摘 | Guarino J Tennyson S McCain G | 2007 | Pediatric Orthopaedic2007，27，8： | 1 |
| 7 | The use of bibliometric and knowledge elicitation techniques to map a knowledge domain-software engineering in the 1990s 显示文摘 | MCCAIN K W VERNER J M HISLOP G W | 2005 | Scientometrics2005，65，1： | 1 |
| 8 | Rapid prototyping technology for surgeries of the pediatric spine and pelvis: benefits analysis 显示文摘 | Guarino J Tennyson S McCain G | 2007 | J Pediatr Orthop2007，8，： | 1 |
| 9 | Legacy tourism: The search for personal meaning in heritage travel显示文摘 | McCain G Ray N | 2003 | Tourism Management2003，24，6： | 1 |
| 10 | Rapid prototyping technology for surgeries of the pediatric spine and pelvis: benefits analysis显示文摘 | Guarino J Tennyson S McCain G | 2007 | J Pediatr Orthop2007，27，8： | 1 |
| 11 | Free Amino Acids in Ham Muscle During Successive Aging Periods and their Relation to Flavor显示文摘 | McCain G R Blumer T N Craig H B | 1968 | Food Science1968，33，2： | 1 |
| 12 | Rapid prototyping tech- nology for surgeries of the pediatric spine and pelvis : benefits anal- ysis 显示文摘 | Guarino J Tennyson S McCain G | 2007 | J Pediatr Orthop2007，27，8： | 1 |
| 13 | NASA/NBS standard reference module for telerobot control system architecture (NASREM)显示文摘 | ALBUS J S MCCAIN H G LUMIA R | 1989 | NIST Technical Note12351989，1989，： | 1 |
| 14 | Legacy tourism:The search for personal meaning in heritage travel 显示文摘 | McCain G Ray N(2003 ) | 2003 | Tourism Management2003，，： | 1 |
| 15 | Free amino acids in ham muscle during successive aging periods and their relation to flavor显示文摘 | McCain G R Blumer T N Craig H B Steel R G | 1968 | Journal of Food Science1968，33，： | 1 |
| 16 | Free amino acids in ham muscle during successive aging periods and their relation to flavor显示文摘 | McCain G R Blumer T N | 1968 | Food Sci1968，33，： | 1 |
| 17 | Legacy tourism:The search for personal meaning in heritage travel 显示文摘 | McCain G Ray N M | 2003 | Tourism Management2003，24，6： | 1 |
| 18 | Rapid prototy-ping technology for surgeries of the pediatric spine and pel-vis:Benefits analysis 显示文摘 | Guarino J Tennyson S McCain G | 2007 | J Pediatr Orthop2007，27，8： | 1 |
| 19 | Rapid prototyping technology for surgeries of the pediatric spine and pelvis: benefits analysis显示文摘 | Guarino J Tennyson S McCain G | 2007 | J Pediatr Orthop2007，27，8： | 1 |
| 20 | Rapid prototyping technology for surgeries of the pediatric and pelvis: benefits analysis 显示文摘 | Guarino J Tennyson S McCain G | 2007 | J Pediatr Orthop2007，27，8： | 1 |
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