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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Influence of Motor Drive Parameters on the Robust Stability of Electric Power Steering Systems显示文摘 | Roy McCann L R Pujara J Lieh | 1998 | IEEE O-7803-4398-0/9981998，，： | 2 |
| 3 | Industrial Clusters:Complexes, Ag- glomeration and/or Social Networks? 显示文摘 | Gordon I R McCann P | 2000 | Urban Studies2000，37，3： | 1 |
| 4 | Industrial clusters,transactions costs and the institutional determinants of mne location behavior显示文摘 | MCCANN P ARITA T GORDON I R | | 0，，11： | 1 |
| 5 | Re-Conceptualizing Command and Control显示文摘 | Pigeau R McCann C | 2002 | Canadian Military Journal2002，13，1： | 1 |
| 6 | Prevalence of asymmetric exophthalmos in Graves orbitopathy显示文摘 | SOROUDI A E GOLDBERG R A MCCANN J D | 2004 | Ophthal Plast Reconstr Surg2004，20，3： | 1 |
| 7 | Neural network analyses of infrared spectra for classifying cell wall architectures 显示文摘 | Mccann M C Defernez M Urbanowicz B R | 2007 | Plant Physiology2007，143，3： | 1 |
| 8 | Prospective evaluation of a Dacron cuffed hemodialysis catheter for prolonged use 显示文摘 | Schwab S Buller G Mccann R | 1988 | Am J Kidney Dis1988，11，2： | 1 |
| 9 | Cerebral venous thrombosis-A pictorial review显示文摘 | Ganeshan D Narlawar R McCann C | | 0，，： | 1 |
| 10 | Ni- trogen-linked diphosphine ligands with ethers attached to nitrogen for chromium-catalyzed ethylene tri- and tet- ramerizations 显示文摘 | ELOWE P R MCCANN C PRINGLE P G | 2006 | Organometallics2006，25，22： | 1 |
| 11 | Industrial clusters: Complexes,agglomeration and/or social networks显示文摘 | Gordon I R McCann P | 2000 | Urban Stud-ies2000，37，3： | 1 |
| 12 | Unique equilibria and substitution effects in a stochas- tic model of the marriage market显示文摘 | DECKER C LIEB E H MCCANN R J | 2013 | Journal of Eco- nomic Theory2013，148，2： | 1 |
| 13 | An attenuation-based sediment classification technique using Chirp sub-bottom profiler data and laboratory acoustic analysis显示文摘 | Stevenson I R McCann C Runciman P B | 2002 | Marine Geophysical Researches2002，23，4： | 1 |
| 14 | The reproducibility of the allergy skin test scoring and interpretation by board-certified/boardeligible allergists显示文摘 | McCann W A Ownby D R | 2002 | Ann Allergy Asthma Immunol2002，89，4： | 1 |
| 15 | A Review of Thin-film Crystalline Silicon for Solar Cell Applications Part 2∶Foreign Substrate显示文摘 | McCann M J Catchpole K R Weber K J | 2001 | Solar Energy Materials and Solar Cells2001，，68： | 1 |
| 16 | Feasibility of calcium peroxide as an oxygen releasing compound in treatment walls显示文摘 | Chevalier L R McCann C | 2008 | International Journal of Environmental Waste Management2008，2，： | 1 |
| 17 | The structure of amorphous carbon nitride films using a combined study of NEXAFS,XPS and Raman spectroscopies显示文摘 | Roy S S McCann R Papakonstantinou P | 2005 | Thin Solid Films2005，482，： | 1 |
| 18 | Laparoscopic common bite duct exploration 显示文摘 | Stoker M E Leveillee R J McCann J C | 1991 | J Laparoendosc Surg1991，1，5： | 1 |
| 19 | Locus of the single- channel bottleneck in dual- task interference显示文摘 | McCann R Johnston J | 1992 | Journal of Experimental Psychology: Human Perception and Performance1992，18，： | 1 |
| 20 | Contemporary man agement of and outcomes from cardiac device related infections 显示文摘 | Margey R McCann H Blake G | 2010 | Europace2010，12，1： | 1 |
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