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| 1 | Cardiovascular autonomic neuropathy in diabetes:Pathophysiology,clinical assessment and implications显示文摘Cardiovascular autonomic neuropathy(CAN)is a debilitating condition that mainly occurs in long-standing type 2 diabetes patients but can manifest earlier,even before diabetes is diagnosed.CAN is a microvascular complication that results from lesions of the sympathetic and parasympathetic nerve fibers,which innervate the heart and blood vessels and promote alterations in cardiovascular autonomic control.The entire mechanism is still not elucidated,but several aspects of the pathophysiology of CAN have already been described,such as the production of advanced glycation end products,reactive oxygen species,nuclear factor kappa B,and pro-inflammatory cytokines.This microvascular complication is an important risk factor for silent myocardial ischemia,chronic kidney disease,myocardial dysfunction,major cardiovascular events,cardiac arrhythmias,and sudden death.It has also been suggested that,compared to other traditional cardiovascular risk factors,CAN progression may have a greater impact on cardiovascular disease development.However,CAN might be subclinical for several years,and a late diagnosis increases the mortality risk.The duration of the transition period from the subclinical to clinical stage remains unknown,but the progression of CAN is associated with a poor prognosis.Several tests can be used for CAN diagnosis,such as heart rate variability(HRV),cardiovascular autonomic reflex tests,and myocardial scintigraphy.Currently,it has already been described that CAN could be detected even during the subclinical stage through a reduction in HRV,which is a non-invasive test with a lower operating cost.Therefore,considering that diabetes mellitus is a global epidemic and that diabetic neuropathy is the most common chronic complication of diabetes,the early identification and treatment of CAN could be a key point to mitigate the morbidity and mortality associated with this long-lasting condition. | Alice Duque Mauro Felippe Felix Mediano Andrea De Lorenzo Luiz Fernando Rodrigues Jr | 2021 | World Journal of Diabetes2021，12，6： | 14 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Production of mouse interleukin - 12 is greater in tobacco hairy roots grown in a mist reactor than in an airlift reactor 显示文摘 | Liu C Towler M J Mediano G et at | 2009 | Biotechnol Bioengineer2009，102，4： | 1 |
| 4 | TEDRA, the development of a software defined cave radio显示文摘 | ViUarroel J Cuchi J Mediano A | 2007 | CREG Journal2007，67，： | 1 |
| 5 | Modulation scheme for improved operation of an RB-IGBT-based resonant inverter applied to domestic induction heating显示文摘 | Sarnago H Lucia O Mediano A | 2013 | IEEE Transactions on Industrial Electronics2013，60，5： | 1 |
| 6 | Daytime sleepiness and polysomnographic variables in sleep apnea patients 显示文摘 | MEDIANO O BARCELO A DE LA PENA M | 2007 | Eur Respir J2007，30，1： | 1 |
| 7 | Design of Class-E amplifier with nonlinear and linear shunt capacitances for any duty cycle 显示文摘 | MEDIANO A MOLINA-GAUDO P BERNAL C | 2007 | IEEE Trans on MTT2007，55，3： | 1 |
| 8 | Isolation and charac- terization of ovine mesenchymal stem cells derived from pe- ripheral blood显示文摘 | Lyahyai J Mediano DR Ranera B | 2012 | BMC Vet Res2012，8，1： | 1 |
| 9 | The influenceof obesity and obstructive sleep apnea on metabolic hormones显示文摘 | Sdnchez-de-la-Torre M Mediano 0 Barceld A | 2012 | Sleep Breath2012，16，3： | 1 |
| 10 | Characterization of a heritable partial monosomy 18p by molecular and cytogenetic analysis显示文摘 | Rigola MA Plaja A Mediano C | 2001 | Am J Med Genet2001，104，1： | 1 |
| 11 | The influence of obesity and obstructive sleep apnea on meta- bolic hormones 显示文摘 | SANCHEZ DE LA TORRE M MEDIANO O BARCELO A | 2012 | Sleep Breath2012，16，3： | 1 |
| 12 | Usefulness of bronchial reactivity analysis in the diagnosis of bronchial asthma in patients with bronchial hyperresponsiveness显示文摘 | García-Río F Mediano O Ramírez M | 2004 | Respir Med2004，98，3： | 1 |
| 13 | Noninvasive measurement of the maximum relaxation rate of inspiratory muscles in patients with neuromuscular disorders显示文摘 | Garcfa-Rfo F Mediano O Pino JM | | 0，，04： | 1 |
| 14 | The influence of obesity and obstructive sleep apnea on metabolic hormones显示文摘 | Srnchezdela Tone M Mediano O Barcel6 A | 2012 | Sleep Breath2012，16，： | 1 |
| 15 | Isolation and characterization of ovine mesencbymal stem cells derived from peripheral blood 显示文摘 | Lyahyai J Mediano DR Ranera B | 2012 | BMC Vet Res2012，8，： | 1 |
| 16 | High-Efficiency Broadband Parallel-Circuit Class E RF Power Amplifier With Reactance-Compensation Technique 显示文摘 | NARENDRA KUMAR CHACKO PRAKASH ANDREI GREBENNIKOV ARTURO MEDIANO | 2008 | IEEE Transactions on Microwave Theory and Techniques2008，56，3： | 1 |
| 17 | Daytime sleepiness and poly- somnographic variables in sleep apnea patients显示文摘 | Mediano O Barcelo A de Lapena M | 2007 | Eur Respir J2007，30，： | 1 |
| 18 | Usefulness of bronchial reactivity analysis in the diagnosis of bronchial asthma in patients with bronchial hyperresponsiveness 显示文摘 | Garcia-Rio F Mediano O Rarairez M | 2004 | Respir Med2004，98，3： | 1 |
| 19 | Direct AC-AC resonant boost converter for efficient domestic induc- tion heating applications显示文摘 | Sarnago H Luc'la O Mediano A | 2014 | IEEE Transactions on Power Electronics2014，29，3： | 1 |
| 20 | A class-E RF power amplifier with a flat-top transistor-voltage waveform显示文摘 | Mediano A Sokal N O | 2013 | IEEE Transactions on Power Electronics2013，28，11： | 1 |
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