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| 1 | Clostridium difficile infections in China显示文摘Clostridium difficile (C. difficile) infection has become one of the major hospital-associated infections in West-ern countries in the last two decades. However, there is limited information on the status of C. difficile infection inChinese healthcare settings. Given the large and increasing elderly population and the well-recognized problem ofover-prescribing of broad spectrum antibiotics in China, it is critical to understand the epidemiology and potentialrisk factors that may contribute to C. difficile infection in China. A literature review of available published studies,including those in Chinese language-based journals, was conducted. A review of the currently available literaturesuggested the presence of C. difficile infections in China, but also suggested that these infections were not particu-larly endemic. This finding should lead to better designed and greatly expanded studies to provide a more reliableepidemiologically-based conclusion on the actual status of C. difficile infection in China, including the identifica-tion of any associated risk factors. Such information is ultimately valuable to develop appropriate strategies to pre-vent C. difficile infection and the vast negative impact of such infections in China and other developing countries. | Ke Jin a,b,c,Shixia Wang c,d,Zuhu Huang a,b,c,Shan Lu b,c,daDepartment of Infectious Diseases,bJiangsu Province Key Laboratory in Infectious Diseases,cChina-US Vaccine ResearchCenter,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China d Department of Medicine,University of Massachusetts Medical School,Worcester,MA 01655,USA. | 2010 | The Journal of Biomedical Research2010，24，6： | 14 |
| 2 | Comparative Study on the Long-term Effect of Permanent Embolization of Hepatic Artery with Bletilla Striata in Patients with 显示文摘ComparativeStudyontheLong-termEffectofPermanentEmbolizationofHepaticArterywithBletillaStriatainPatientswithPrimaryLiverCancer... | FENG Gansheng Cramann B ZHENG Zhuansheng et al(Department of Radiology,Xiehe Hospital, Tongji Medical University,Wuhan 430030 Abteilung fur Radio-Diagnostik,Universitatsklinik,Homburg/Saar,Deutschland) | 1996 | Journal of Huazhong University of Science and Technology(Medical Sciences)1996，16，2： | 8 |
| 3 | Effects of disinhibition on spatiotemporal pattern of neuronal first recruitment in neuronal networks显示文摘The propagation of neuronal activities is a key feature to understanding information processing in networks. The analysis based on first-spikes of bursts in turn plays an important role in the research of neuronal activity propagation. Our focus here is to investigate how spatiotemporal patterns of neuronal first-spikes are affected by disinhibition. Multi-electrode arrays were used to record stimulation-evoked bursts of multiple neurons in randomly cultured neuronal networks. Both the precise timing of and the rank relationships between first-spikes were analyzed. Compared with evoked bursts in the network's native state, the precise first-spike latencies in its dis-inhibited state are more consistent and the propagation of its bursting activities is much faster. Additional points of interest are that disinhibited neuronal networks can be evoked to generate stable and distinguishable neuronal first recruitment spatiotemporal patterns specific to the stimulation site, and that the disinhibition may cause the original spatiotemporal patterns to change in a heterogeneous manner with regards to different propagation pathways. | Liangbin Pana,b,c,1, Xindong Songa,b,c,1, Guangxin Xiang a,b,c, Jing Zhua,b,c, Jing Cheng a,b,c,d,a Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China b Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China c National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, China d State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 6 |
| 4 | High performance liquid chromatographic separation of thirteen drugs collected in Chinese Pharmacopoeia 2010(Ch.P2010) on cellulose ramification chiral stationary phase显示文摘The enantiomers separation of thirteen drugs collected in Ch.P2010 was performed on chiral stationary phase of cellulose ramification (chiralpak OD and chiralpak OJ) by high performance liquid chromatographic (HPLC) methods, which included ibuprofen (C1), ketoprofen (C2), nitrendipine (C3), nimodipine (C4), felodipine (C5), omeprazole (C6), praziquantel (C7), propranolol hydrochloride (C8), atenolol (C9), sulpiride (C10), clenbuterol hydrochloride (C11), verapamil hydrochloride (C12), and chlorphenamine maleate (C13). The mobile phase consisted of isopropanol and n-hexane. The detection wavelength was set at 254 nm and the fiow rate was 0.7 mL/min. The enantiomers separation of these thirteen racemates on chiralpak OD column and chiralpak OJ column was studied, while the effects of proportion of organic additives, alcohol displacer and temperature on the separation were studied. And the mechanism of some of racemates was discussed. The results indicated that thirteen chiral drugs could be separated onchiral stationary phase of cellulose ramification in normal phase chromatographic system. The chromatographic retention and resolution of enantiomers could be adjusted by factors including column temperature and the concentration of alcohol displacer and organic alkaline modifier in mobile phase. It was shown that the resolution was improved with reducing concentration of alcohol displacer. When concentration of organic alkaline modifier was 0.2% (v/v), the resolution and the peak shape were fairly good. Most racemates mentioned above had better resolution at column temperature of 25 1C. When racemates were separated, the temperature should be kept so as to obtain stable separation results. | Ying Zhoua,b, Chao Maa, Yan Wanga, Qi-Ming Zhangb, Yi-Ying Zhanga, Jie Fua, Hong Gaoc, Li-Xun Zhaoc aState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China bNational Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China cInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China | 2012 | Journal of Pharmaceutical Analysis2012，2，1： | 4 |
| 5 | Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers显示文摘In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cy-clinD1 accelerated the progression of cell cycle. | SONG Xin1, TAO Yongguang1, ZENG Liang1, YANG Jing1, TANG Faqing1, Leo M. Lee2, GONG Jianping3, WU Qiao4 & CAO Ya1 1. Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China 2. Laboratory of Molecular Technology SAIC-Frederick, National Cancer Institute P.O. Box B, Frederick, MD 21702, USA 3. Molecular Medical Center, Tongji Hospital, Tongji Medical University, Wuhan 430030, China 4. Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China | 2005 | Science China(Life Sciences)2005，48，4： | 4 |
| 6 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 7 | S and Canada显示文摘 | Anderson M B Kanter S L Medical Education in the U | 2010 | Academic Medicine2010，85，9： | 1 |
| 8 | Viral antibody complexes in canine adenovirus type-1 (CAV-1) ocular lesions leukocyte chemotaxis and enzyme release显示文摘 | Medic B L Bistner S I | 1975 | Cornell Vet1975，65，3： | 1 |
| 9 | Stochastic optimization and distribution in disaster management显示文摘 | Mete H O Zabinsky Z of medical supply location B | 2010 | Int J of Production Economics2010，126，1： | 1 |
| 10 | Mutual- images : a survey显示文摘 | Pluim J P W Maintz J B A information-based registration Viergever M of medical A | 2003 | IEEE Transactions on Medical Imaging2003，22，8： | 1 |
| 11 | Acute pretreatment with chloroquine attenuates renal I/R injury in rats 显示文摘 | Todorovic Z Medic B Basta-Jovanovic G | 2014 | PLoS One2014，9，92： | 1 |
| 12 | Role of Notch expression in premature senescence of murine bone marrow stromal cells显示文摘The aim of the present study was to investigate the role of the Notch signaling pathway in premature senescence of murine bone marrow stromal cells in vitro. The intracellular domain of Notch 1 (ICN) was transfected into cultured murine bone marrow stromal cells by lipofectamine transfection. After three days, the proliferation of transfected cells was measured by MTT assay. Cell cycle distribution was analyzed by flow cytometry. Senescence-associated beta-galactosidase (SA-beta-gal) was measured, and the percentage of positive cells was evaluated by assessing 1000 cells in random fields of view. The expressions of p53 and p21Cip1/Waf1 were analyzed by both RT-PCR and Western blot analysis. The results showed that activation of Notch signaling inhibited proliferation of murine bone marrow stromal cells with induction of G1 arrest, increased the percentage of SA-beta-gal positive cells, and upregulated p53 and p21Cip1/Waf1 mRNA and protein expression levels. Thus, the activated Notch signaling could induce premature senescence of bone marrow stromal cells through the p53-p21Cip1/Waf1 pathway. | Kejie Zhanga,b, Lifang Huang b, Hanying Sunb, Yan Zhub, Yi Xiaob, Mei Huang b, Wenli Liub,a Department of Hematology, Zhongshan Hospital, Xiamen University, Fujian Medical University Clinic Teaching Hospital, Xiamen 361004, China b Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 1 |
| 13 | Hemorrhagic fever with renal syndrome:imported or native disease in the region显示文摘 | Daclajia B Medic A Avsic-Zupanc T | 2003 | Acta Med Croatica2003，57，5： | 1 |
| 14 | Acute pre- treatment with chloroquine attenuates renal I/R injury in rats~显示文摘 | Todorovic Z Medic B Basta-Jovanovic G | 2014 | PLoS ONE2014，9，92： | 1 |
| 15 | Formu- Gel and its UV protective study of ina] flowers 显示文摘 | Patil S B lation of some medic 2011 1 (2) Patil V V Ghodke D S | 2011 | Asian J Pharm Ana2011，3435，： | 1 |
| 16 | Malignancies diagnosed during pregnancy and treated with chemotherapy or other modalities (review of 27 cases): multieenter experiences显示文摘 | Anatolian Medical Oncology Society Group Ustaalioglu B B Gumus M Unal A | 2010 | Int J Gy- necol Cancer2010，20，5： | 1 |
| 17 | The Aspergillus nidulans F-box protein GrrA links SCF activity to meiosis 显示文摘 | Krappmann S Jung N Medic B | 2006 | Mol Microhiol2006，61，： | 1 |
| 18 | Hemorrhagic fever with renal syndrome: imported or native disease in the region 显示文摘 | Daelaija B Medic A Avsic-Zupanc T | 2003 | Acta Med Croatica2003，57，5： | 1 |
| 19 | Mapping and characterization of two relevance networks from SNP and gene levels显示文摘Variations of gene expression and DNA sequence are genetically associated. The goal of this study was to build genetic networks to map from SNPs to gene expressions and to characterize the two different kinds of networks. We employed mutual information to evaluate the strength of SNP-SNP and gene-gene associations based on SNPs identity by descent (IBD) data and differences of gene expressions. We applied the approach to one dataset of Genetics of Gene Expression in Humans, and discovered that both the SNP relevance network and the gene relevance network approximated the scale-free topology. We also found that 12.09% of SNP-SNP interactions matched 24.49% of gene-gene interactions, which was consistent with that of the previous studies. Finally, we identified 49 hub SNPs and 115 hub genes in their relevance networks, in which 27 hub SNPs were associated with 25 hub genes. | Wei Jiang a,1, Lijie Zhang b,1, Bo Na a, Lihong Wanga, Jiankai Xu a, Xia Li a,b,c, Yadong Wangb, Shaoqi Rao da College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, China b Department of Mathematics and Computer Science, Harbin Institute of Technology, Harbin 150080, China c Department of Bioinformatics, Capital University of Medical Sciences, Beijing 100084, China d Department of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, 9600 Euclid Avenue, Cleveland, OH 44195, USA | 2009 | Progress in Natural Science:Materials International2009，19，5： | 0 |
| 20 | Switching Phenomena of CuTCNQ Induced Mainly by the Interaction among Microcrystaline Grains显示文摘CuTCNQ organic films were prepared separately by spontaneous charge transfer(CT) reaction of Cu with TCNQ in an acetonitrile or thermally activated solid phase diffusion and CT reaction of an alternative vapor deposition of Cu and TCNQ thin films. The m | Gu Ning a1 Sheng Haoying b Lu Wu a1 Pang Shuming a2 Zhang Lan b Wei Yu a1 ( a1 Department of Biology Science and Medical Engineering,Southeast University,Nanjing 210018) ( a2 Department of Electronics Engineering, South | 1996 | Journal of Southeast University(English Edition)1996，12，1： | 0 |
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