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| 1 | Pathological changes in the cellular structures of retina and choroidea in the early stages of alloxan-induced diabetes显示文摘AIM To investigate the temporal sequence of pathological changes in the cellular structures of retina and choroidea in the early stages of diabetes in laboratory animals.METHODS Experimental type 1 diabetes was modeled by three intraperitoneal injections of an alloxan solution into 30 male nonlinear rats at 16 wk of age. The 30 th and 60 th days from the final alloxan injection were chosen as the endpoints. Light and electron microscopy and morphometric and immunohistochemical studies were performed on histological slices of eyeballs from experimental animals.RESULTS Diabetic disturbances progressed to 60 d of the experiment. Thus, in the retina, a partial destruction of photoreceptors accompanied by interstitial edema was observed. The morphometric analysis revealed a reduction in the thickness of the retina. A reduction in the number of blood vessels of the choroid with disturbances of the endothelial cells and the vascular walls and a persistent reduction in the number of melanocytes were observed. The number of proliferating Ki-67 positive cells decreased, and the number of macrophages increased with diabetes development.CONCLUSION The starting point in the development of destructive changes involves early reduction in the number of melanocytes of the choroidea and alterations in the retinal pigment epithelium. | Irina Danilova Svetlana Medvedeva Svetlana Shmakova Margarita Chereshneva Alexey Sarapultsev Petr Sarapultsev | 2018 | World Journal of Diabetes2018，9，12： | 6 |
| 2 | The presence of ANP in rat peritoneal mast cells显示文摘Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fraction of mast cells was obtained by separation of rat peritoneal cells on a Percoll density gradient. By Western blotting, two ANP-immunoreactive proteins of molecular masses of 2.5 kDa and 16.9 kDa were detected in lysates from these mast cells. Electron microscope immunogold labeling has revealed the presence of ANP-immunoreactive material in storage, secreting and released granules of mast cells. Our findings indicate the rat peritoneal mast cells to contain both ANP prohormone and ANP. These both peptides are located in mast cell secretory granules and released by mechanism of degranulation. It is discussed that many mast cell functions might be due to production of natriuretic peptides by these cells. | Marina G MARTYNOVA Olga A BYSTROVA Olga M MOISEEVA Anton L EVDONIN Kirill A KONDRATOV Natalja D MEDVEDEVA | 2005 | Cell Research2005，15，10： | 3 |
| 3 | 利用OH夜气辉反演原子氧数密度时输入参数的不确定度对反演结果的影响显示文摘借助OH夜气辉辐射的光化学模式,由OH夜气辉辐射反演中间层-低热层区域的原子氧数密度时,输入参数的不确定性将导致反演得到的原子氧数密度具有不确定性.以在sudden death猝灭模式下通过OH_((8-3))振动带体辐射率反演原子氧数密度为例,分别研究了大气参数和OH气辉辐射率的不确定度引起的反演不确定度、化学反应速率常数的不确定度引起的反演不确定度,以及所有输入参数的不确定度共同引起的反演不确定度,找出其不确定度对反演结果影响最大的参数.结果表明,三种反演不确定度均随着高度的升高而增大,温度和体辐射率的不确定度对第一种反演不确定度的贡献最大,反应速率常数b_((8))和A_((8-3))的不确定度对第二种反演不确定度的贡献最大. | 高红 徐寄遥 陈光明 袁韡 Schulte W Mikhalev A V Medvedeva I V | 2009 | 空间科学学报2009，29，3： | 2 |
| 4 | Ternary site pre- ference energies, size misfits and solid solution hardening in NiA1 and FeAI显示文摘 | Medvedeva M I Gornostyrev Y N | 1998 | Acta Mater1998，46，12： | 1 |
| 5 | Quantum-chemical analysis of the chemical stability and cohesive properties of hexagonal TiB 2 , VB 2 , ZrB 2 and NbB 2显示文摘 | Alexander L. Ivanovsky Nadezhda I. Medvedeva Julia E. Medvedeva | 1998 | Mendeleev Communications1998，，： | 1 |
| 6 | Hydrogen reduction of vanadium in vanadium-doped LiMnPO4 显示文摘 | Kellerman D G Chukalkin Y G Medvedeva N L | 2015 | Materials Chemistry and Physics2015，，： | 1 |
| 7 | Role of embedded clustering in dilute magnetic nitrides: Cr doped GaN显示文摘 | Cui X Y Medvedeva J E Delley B | 2005 | Phys Rev Lett2005，95，25： | 1 |
| 8 | IntracellularZn2+ accumulation contributes to synaptic failure, mitochon-drial depolarization, and cell death in an acute slice oxygen -glucose deprivation model of ischemia显示文摘 | Medvedeva YV Lin B Shuttleworth CW | 2009 | J Neurosci2009，294，： | 1 |
| 9 | Stability of binary and ternary M23C~ carbides from first principles 显示文摘 | Medvedeva N I Van Aken D C Medvedeva J E | 2015 | Computational Materials Science2015，，96： | 1 |
| 10 | Application of autocartilage for treatment of tracheostenosis with chondromalacia 显示文摘 | Bystrenin AV Davydov RS Medvedeva Slu | 2005 | Vestn Otorinolaringol2005，3，： | 1 |
| 11 | Modern view on the problem of retinopathy of preterm babies显示文摘 | KLIMKIN A S MEDVEDEVA M V | 2014 | Vestn Ross Akad Med Nauk2014，，34： | 1 |
| 12 | Application of autocartilage for treatment of tracheostenosis with chondromalacia 显示文摘 | Bystrenin AV Davydov BS Medvedeva SIu | 2005 | Vestn Otorinolaringol2005，3，： | 1 |
| 13 | Phase Diagram of the TinTin Arsenide System显示文摘 | Vdovina T Z Medvedeva Z S | 1974 | Zh Neorg Khim1974，19，8： | 1 |
| 14 | Role of embedded clustering in dilute magnetic semiconductors: Cr doped GaN显示文摘 | Cui X Y Medvedeva J E Delley B | 2005 | Physical Review Letters2005，95，25： | 1 |
| 15 | Obtaining of Ni-P- TiO2 composite coatings with TiO2 sol and surfactants and their properties显示文摘 | Subakova I Petukhov I Medvedeva N | 2015 | Mater Manufacturing Processes2015，30，6： | 1 |
| 16 | 查看详情显示文摘 | Ivanovskaya W Enyashin AN Medvedeva NI | | 0，，03： | 1 |
| 17 | On the corrosion state of plants for purifying natural gas from acid components显示文摘 | Medvedeva M L Gur'yanov V V | 2002 | Protection of Metals2002，38，3： | 1 |
| 18 | Ternary site preference energies, size misfits and solid solution hardening in NiAI and FeAI显示文摘 | MEDVEDEVA M I GORNOSTYREV Y N NOVIKOV D L MRYASOV 0 N FREEMAN A J | 1998 | Acta Materialia1998，46，10： | 1 |
| 19 | 显示文摘 | Cui X Y Medvedeva J E Delley B | 2005 | Phys Rev Lett2005，95，25： | 1 |
| 20 | Intracelluar Zn^2+ accumulation contributes to synaptic failure, mitochon- drial depolarization, and cell death in an acute slice oxygen glucose deprivation (OGD) model of ischemia 显示文摘 | Medvedeva YV Lin B Shuttlewworth CW | 2009 | J Neurosci2009，29，： | 1 |
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