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3篇 您的检索式：作者名="Medvedovic Mario"

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		题名	作者	年代	出处	被引量
	1	Loss of IKB kinase βpromotes myofibroblast transformation and senescence through activation of the ROS-TGFβ autocrine loop显示文摘	Liang Chen Zhimin Peng Qinghang Meng Maureen Mongan Jingcai Wang Maureen Sartor Jing-Chen Liang Niu Mario Medvedovic Winston Kao Ying Xia	2016	Protein & Cell2016，7，5：	4
	2	Bayesian infinite mixture model based clustering of gene expression profiles显示文摘	Medvedovic Mario Sivaganesan Siva	2002	Bioinformatics2002，18，9：	1
	3	NBCe1 Na+-HCO3-cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo显示文摘AIM To investigate the hypothesis that cardiomyocytespecific loss of the electrogenic NBCe1 Na^+-HCO3^- cotransporter is cardioprotective during in vivo ischemiareperfusion(IR)injury.METHODS An NBCe1 (Slc4a4 gene) conditional knockout mouse(KO)model was prepared by gene targeting.Cardiovascular performance of wildtype (WT) and cardiac-specific NBCe1 KO mice was analyzed by intraventricular pressure measurements,and changes in cardiac gene expression were determined by RNA Seq analysis.Response to in vivo IR injury was analyzed after 30 min occlusion of the left anterior descending artery followed by 3 h of reperfusion. RESULTS Loss of NBCe1 in cardiac myocytes did not impair cardiac contractility or relaxation under basal conditions or in response toβ-adrenergic stimulation,and caused only limited changes in gene expression patterns,such as those for electrical excitability.However,following ischemia and reperfusion,KO heart sections exhibited significantly fewer apoptotic nuclei than WT sections.CONCLUSION These studies indicate that cardiac-specific loss of NBCe1 does not impair cardiovascular performance,causes only minimal changes in gene expression patterns,and protects against IR injury in vivo.	Kanimozhi Vairamani Vikram Prasad Yigang Wang Wei Huang Yinhua Chen Mario Medvedovic ohn N Lorenz Gary E Shull	2018	World Journal of Cardiology2018，10，9：	0

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