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| 1 | Clarifying sub-genomic positions of QTLs for flowering habit and fruit quality in U.S. strawberry (Fragaria×ananassa) breeding populations using pedigree-based QTL analysis显示文摘The cultivated strawberry(Fragaria×ananassa)is consumed worldwide for its flavor and nutritional benefits.Genetic analysis of commercially important traits in strawberry are important for the development of breeding methods and tools for this species.Although several quantitative trait loci(QTL)have been previously detected for fruit quality and flowering traits using low-density genetic maps,clarity on the sub-genomic locations of these QTLs was missing.Recent discoveries in allo-octoploid strawberry genomics led to the development of the IStraw90 single-nucleotide polymorphism(SNP)array,enabling high-density genetic maps and finer resolution QTL analysis.In this study,breeder-specified traits were evaluated in the Eastern(Michigan)and Western(Oregon)United States for a common set of breeding populations during 2 years.Several QTLs were validated for soluble solids content(SSC),fruit weight(FWT),pH and titratable acidity(TA)using a pedigree-based QTL analysis approach.For fruit quality,a QTL for SSC on linkage group(LG)6A,a QTL for FWT on LG 2BII,a QTL for pH on LG 4CII and two QTLs for TA on LGs 2A and 5B were detected.In addition,a large-effect QTL for flowering was detected at the distal end of LG 4A,coinciding with the FaPFRU locus.Marker haplotype analysis in the FaPFRU region indicated that the homozygous recessive genotype was highly predictive of seasonal flowering.SNP probes in the FaPFRU region may help facilitate marker-assisted selection for this trait. | Sujeet Verma Jason D Zurn Natalia Salinas Megan M Mathey Beatrice Denoyes James F Hancock Chad E Finn Nahla V Bassil Vance M Whitaker | 2017 | Horticulture Research2017，4，1： | 10 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Modulation of tau phosphorylation by environmental copper显示文摘Background:The transition metal copper enhances amyloidβaggregation and neurotoxicity,and in models of concomitant amyloid and tau pathology,copper also promotes tau aggregation.Since it is not clear if the effects of environmental copper upon tau pathology are dependent on the presence of pathological amyloidβ,we tested the effects of copper overload and complexing in disease models which lack pathological amyloidβ.Methods:We used cell culture and transgenic murine models to test the effects of environmental copper on tau phosphorylation.We used oral zinc acetate as a copper lowering agent in mice and examined changes in blood and brain metals through inductively coupled plasma mass spectroscopy.Behavioral effects of copper lowering were assessed with Morris water maze and novel object recognition tasks.Changes in tau phosphorylation were examined by phosphorylation specific antibodies on Western blots.Results:In human neuroblastoma cells,excess copper promoted tau phosphorylation and a copper complexing agent,tetrathiomolybdate,attenuated tau phosphorylation.In a transgenic mouse model expressing wild type human tau,copper-lowering by oral zinc suppressed plasma and brain levels of copper,and resulted in a marked attenuation of tau phosphorylation.No significant changes in behavior were observed with copper lowering,but a trend to improved recognition of the novel object was observed in zinc acetate treated mice.Conclusions:We propose that reduction of brain copper by blocking uptake of copper from the diet may be a viable strategy for modulating tau pathology in Alzheimer’s disease.The potential benefits of this approach are tempered by the absence of a behavioral benefit and by the health risks of excessive lowering of copper. | Kellen Voss Christopher Harris Martina Ralle Megan Duffy Charles Murchison Joseph F Quinn | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 4 | A processing, characterization and marine biodegradation study of melt-extruded polyhydroxyalkanoate (pha) films显示文摘 | Christopher T Megan C Danielle F | 2008 | Journal of Polymers and Environment2008，16，1： | 1 |
| 5 | An investigation of boron toxicity in barley using metabolomics显示文摘 | Ute R John H P Megan G F | 2006 | Plant Physiology2006，142，： | 1 |
| 6 | Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats显示文摘 | Megan R D Lesley C F Violetta MG | 2008 | Exp Neurol2008，212，2： | 1 |
| 7 | Simultaneous sorption of benzene and heavy metals onto two organoclays显示文摘 | Vinka A O C Megan F James A S | 2007 | Journal of CoIloid and Interface Science2007，，309： | 1 |
| 8 | Self-regulation and personality: how interventions increase regulatory success, and how depletion moderates the effects of traits on behavior显示文摘 | Baumeister Roy F Gailliot Matthew DeWall C Nathan Oaten Megan | 2006 | Journal of Personality2006，74，6： | 1 |
| 9 | Feeding long - chain n -3 polyunsaturated fatty acids to obese leptin recep- tor- deficient JCR:LA -cp rats modifies immune function and lipid- raft fatty acid composition显示文摘 | Megan R R Spencer D P Catherine J F | 2009 | British Journal of Nutrition2009，101，： | 1 |
| 10 | Human natural killer cells: aunique innate immunoregulatory role for the CD56bright subset显示文摘 | Megan A C Todd A F Sarah C | 2001 | Blood2001，97，： | 1 |
| 11 | Recent development in thin film ahdesion measurement 显示文摘 | Megan J Cordill David F Bahr | 2004 | IEEE Transactions on Device and Materials Reliability2004，4，2： | 1 |
| 12 | Underwater radiated noise from modern commercial ships显示文摘 | MEGAN F DONALD R SEAN M | 2012 | Jour- nal of tile Acoustical Society of America2012，131，1： | 1 |
| 13 | Hydrocarbon spills on Antarctic soils: effects and management 显示文摘 | Jackie M A Megan R B Julia M F | 2004 | Environmental Science and Technology2004，38，： | 1 |
| 14 | Phe- notypic screening with oleaginous microalgae reveals modu- lators of lipid productivity 显示文摘 | ANNALIESE K F MEGAN A D DIANA M W | 2013 | ACS Chem Biol2013，8，5： | 1 |
| 15 | 显示文摘 | Vinka A O Megan F | 2007 | Journal of Colloid and Interface Science2007，309，： | 1 |
| 16 | Global mapping of topography on transition zone velocity discontinuities by stacking SS precursors显示文摘 | Megan P F Shearer P M | 1998 | J Geophys Res1998，103，： | 1 |
| 17 | A technology-assisted learning setup as assessment supplement for three persons with a diagnosis of post-coma vegetative state and pervasive motor impairment显示文摘 | Lancioni GE Singh NN O'Reilly MF Sigafoos J Buonocunto F Sacco V Colonna F Navarro J Lanzilotti C Bosco A Megan G De tommaso M | 2009 | Res Dev Disabil2009，30，： | 1 |
| 18 | An investigation of boron toxicity in barley using metabolomics显示文摘 | Ute R John H P Megan G F | 2006 | Plant Physiology2006，142，： | 1 |
| 19 | Improving access to analgesic drugs for patients with cancer in sub-Saharan Africa显示文摘 | Megan O’Brien Faith Mwangi-Powell Isaac F Adewole Olaitan Soyannwo Jacinto Amandua Elizabeth Ogaja Mary Okpeseyi Zipporah Ali Rose Kiwanuka Anne Merriman | 2013 | Lancet Oncology2013，，4： | 1 |
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