|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunological changes in different patient populations with chronic hepatitis C virus infection显示文摘AIM: To investigate killer inhibitory and activating receptor expression by natural killer(NK), natural killer T-like(NKT-like) and CD8+ T lymphocytes in patients with chronic hepatitis C virus(HCV) infection with elevated and with persistently normal alanine aminotransferase(PNALT).METHODS: The percentage of peripheral blood Treg cells, KIR2DL3, ILT-2, KIR3DL1, CD160, NKG2 D, NKG2 C expressing NK, T and NKT-like cells, cytokine production and NK cytotoxicity were determined by flow cytometry. Twenty-one patients with chronic HCV infection with elevated alanine aminotransferase, 11 HCV carriers with persistently normal alanine aminotransferase and 15 healthy volunteers were enrolled. RESULTS: No significant differences were observed in the percentage of total T, NK or NKT-like cells between study groups. Comparing the activating and inhibitoryreceptor expression by NK cells obtained from HCV carriers with PNALT and chronic HCV hepatitis patients with elevated alanine aminotransferase, NKG2 D activating receptor expression was the only receptor showing a significant difference. NKG2 D expression of NK cells was significantly lower in patients with elevated alanine aminotransferase. The expression of CD160, NKG2 D and NKG2 C activating receptor by CD8+ T cells were significantly lower in patients with chronic HCV hepatitis than in healthy controls and in HCV carriers with PNALT. Plasma TGF-β1 levels inversely correlated with NKG2 D expression by NK cells. In vitro TGF-β1 treatment inhibited NK cells cytotoxic activity and downregulated NKG2 D expression. CD8+ T cells from HCV carriers with PNALT showed significantly elevated expression of CD160, NKG2 D and NKG2 C activating receptors compared to chronic HCV patients with elevated alanine aminotransferase. Enhanced expression of inhibitory KIR2DL3 receptor, and decreased ILT-2 expression on NK cells were also found in chronic hepatitis C patients compared to healthy controls.CONCLUSION: Our study demonstrated a complex dysregulation of activating and inhibitory receptor expression, such as decreased NKG2 D and CD160 activating receptor expression and increased KIR2DL3 inhibitory receptor expression by NK and cytotoxic T cells and may provide further mechanism contributing to defective cellular immune functions in chronic hepatitis C. Increased NKG2 D receptor expression in HCV patients with persistently normal ALT suggests an important pathway for sustaining NK and CD8 T cell function and a protective role against disease progression. | Laszlo Szereday Matyas Meggyes Melinda Halasz Julia Szekeres-Bartho Alajos Par Gabriella Par | 2016 | World Journal of Gastroenterology2016，22，20： | 5 |
| 2 | Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy显示文摘 | Szereday L Miko E Meggyes M | 2012 | AmJ Reprod Immunol2012，67，： | 1 |
| 3 | Peripheral blood TIM-3 positive NK and CD8 + T cells throughout preg- nancy: TIM-3/Galectin-9 interaction and its possible role during pregnancy显示文摘 | Meggyes M Miko E Polgar B | 2014 | PLoS One2014，9，92： | 1 |
| 4 | Possible role of natural killer and natural killer T-like cells in implantation failure after IVF显示文摘 | Eva Miko Zoltan Manfai Matyas Meggyes Aliz Barakonyi Ferenc Wilhelm Akos Varnagy Jozsef Bodis Zsolt Illes Julia Szekeres-Bartho Laszlo Szereday | 2010 | Reproductive BioMedicine Online2010，，6： | 1 |
| 5 | Paste technology for tailings management 显示文摘 | Meggyes T Debreczeni A | 2006 | Land Contamination & Reclamation2006，14，4： | 1 |
| 6 | Possible role of natural killer and natural killer T-like cells in implantation failure after IVF显示文摘 | Eva Miko Zoltan Manfai Matyas Meggyes Aliz Barakonyi Ferenc Wilhelm Akos Varnagy Jozsef Bodis Zsolt Illes Julia Szekeres-Bartho Laszlo Szereday | 2010 | Reproductive BioMedicine Online2010，，6： | 1 |
| 7 | Removal of Organic and Inorganic Pollutants from Groundwater Using Permeable Reactive Barriers 显示文摘 | Franz - Georg Simon Tamos Meggyes | 2000 | Land Contamination & Reclamation2000，8，2： | 1 |
| 8 | Removal of organicand inorganic pollutants from groundwater using permeable reactive harriers显示文摘 | Franz George Simon Tamils Meggyes | 2000 | Land Contamination & Reclamation2000，8，2： | 1 |
| 9 | Removeal of organic and inorganic pollutants from groundwater using permeable reactive barriers 显示文摘 | SIMON F G MEGGYES T | 2000 | Land Contamination & Reclamation2000，8，2： | 1 |
| 10 | Possible role of natural killer and natural killer T-like cells in implantation failure after IVF显示文摘 | Miko E Manfai Z Meggyes M | 2010 | Reprod Biomed Online2010，21，6： | 1 |
| 11 | Possible role of natural killer and natural killer T - like cells in implantation failure after IVF显示文摘 | Miko E Manfai Z Meggyes M Barakonyi A | 2010 | Reprod Biomed Online2010，21，6： | 1 |
| 12 | Removal of organic and inorganic pollutants from groundwater using permeable reactive barriers 显示文摘 | Franz-Georg Simon Tamas Meggyes | 2000 | Land Contamination & Reclamation2000，8，2： | 1 |
| 13 | Peripheral blood TIM - 3 posi- tive NK and CD8 ~ T cells throughout pregnancy: TIM -3/galectin - 9 interaction and its possible role during pregnancy 显示文摘 | Meggyes M Miko E Polgar B | 2014 | PLoS One2014，9，92： | 1 |
| 14 | Removal of organic and inorganic pollutants from groundwater using permeable reactive barriers显示文摘 | Tamas Meggyes | 2000 | Land Contamination & Reclamation2000，8，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员