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| 1 | Safety of gastrointestinal endoscopy with conscious sedation in obstructive sleep apnea显示文摘AIM To perform a systematic review and meta-analysis to assess the safety of conscious sedation in patients with obstructive sleep apnea(OSA).METHODS A comprehensive electronic search of MEDLINE and EMBASE was performed from inception until March 1, 2015. In an effort to include unpublished data, abstracts from prior gastroenterological society meetings as well as other reference sources were interrogated. After study selection, two authors utilizing a standardized data extraction form collected the data independently. Any disagreements between authors were resolved by consensus among four authors. The methodological quality was assessed using the Newcastle Ottawa tool for observational studies. The primary variables of interest included incidence of hypoxia, hypotension, tachycardia, and bradycardia. Continuous data were summarized as odds ratio(OR) and 95%CI and pooled using generic inverse variance under the random-effects model. Heterogeneity between pooled studies was assessed using the I2 statistic.RESULTS Initial search of MEDLINE and EMBASE identified 357 citations. A search of meeting abstracts did not yield any relevant citations. After systematic review and exclusion consensus meetings, seven studies met the a priori determined inclusion criteria. The overall methodological quality of included studies ranged from moderate to low. No significant differences between OSA patients and controls were identified among any of the study variables: Incidence of hypoxia(7 studies, 3005 patients; OR = 1.11; 95%CI: 0.73-1.11; P = 0.47; I2 = 0%), incidence of hypotension(4 studies, 2125 patients; OR = 1.10; 95%CI: 0.75-1.60; P = 0.63; I2 = 0%), incidence of tachycardia(3 studies, 2030 patients; OR = 0.94; 95%CI: 0.53-1.65; P = 0.28; I2 = 21%), and incidence of bradycardia(3 studies, 2030 patients; OR = 0.88; 95%CI: 0.63-1.22; P = 0.59; I2 = 0%).CONCLUSION OSA is not a significant risk factor for cardiopulmonary complications in patients undergoing endoscopic procedures with conscious sedation. | Christian M Andrade Brijesh Patel Meghana Vellanki Ambuj Kumar Gitanjali Vidyarthi | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，11： | 4 |
| 2 | Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion显示文摘Osteocytes are mechanosensitive bone cells, but little is known about their effects on tumor cells in response to mechanical stimulation. We treated breast cancer cells with osteocyte-derived conditioned medium(CM) and fluid flow-treated conditioned medium(FFCM) with 0.25 Pa and 1 Pa shear stress. Notably, CM and FFCM at 0.25 Pa induced the mesenchymal-to-epithelial transition(MET), but FFCM at 1 Pa induced the epithelial-to-mesenchymal transition(EMT). This suggested that the effects of fluid flow on conditioned media depend on flow intensity. Fluorescence resonance energy transfer(FRET)-based evaluation of Src activity and vinculin molecular force showed that osteopontin was involved in EMT and MET switching. A mouse model of tumorinduced osteolysis was tested using dynamic tibia loadings of 1, 2, and 5 N. The low 1 N loading suppressed tumor-induced osteolysis, but this beneficial effect was lost and reversed with loads at 2 and 5 N, respectively. Changing the loading intensities in vivo also led to changes in serum TGFβ levels and the composition of tumor-associated volatile organic compounds in the urine.Collectively, this study demonstrated the critical role of intensity-dependent mechanotransduction and osteopontin in tumorosteocyte communication, indicating that a biophysical factor can tangibly alter the behaviors of tumor cells in the bone microenvironment. | Yao Fan Aydin Jalali Andy Chen Xinyu Zhao Shengzhi Liu Meghana Teli Yunxia Guo Fangjia Li Junrui Li Amanda Siegel Lianxiang Yang Jing Liu Sungsoo Na Mangilal Agarwal Alexander G.Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota | 2020 | Bone Research2020，8，2： | 4 |
| 3 | GRADE证据质量评级及其在循证实践中的重要性显示文摘GRADE方法是批判性评价对照研究和为系统评价提供建议的主流工具之一。循证实践是现代医学实践中不可或缺的一部分,忽视证据和证据质量的现代医疗是无法想象的~1。然而,循证医学并不像人们认为的那样完美。在当代研究中,学者们总是会对证据质量提出质疑。《柳叶刀》杂志总编理查德·霍顿(Richard Horton)曾在《柳叶刀》上发文指出,由于纳入研究样本量较小、研究差异无统计学意义、分析方法不恰当、利益冲突明显、或对流行趋势的盲从等因素,近50%的科学文献可能存在错误或造假~2。 | Anil Kumar Meghana Taggarsi 王瑞(翻译) 张崇凡(翻译) 夏君(翻译) | 2021 | 中国医院院长2021，17，14： | 3 |
| 4 | Superior safety of direct oral anticoagulants compared to Warfarin in patients with atrial fibrillation and underlying cancer: a national veterans affairs database study显示文摘Background Studies evaluating safety of warfarin and direct oral anticoagulants(DOACs) for prevention of stroke in patients with atrial fibrillation(AF) are lacking. Methods & Results All patients(n = 196,521) receiving care at veteran’s affairs with active cancer and AF from 2010–2015 were included. One-year mortality was significantly higher in unadjusted analysis with warfarin(44.9%) compared to dabigatran(25%, P < 0.001), rivaroxaban(24.4%, P < 0.001) and apixaban(30%, P < 0.001) and after adjusting for age, sex and type of cancer mortality(OR = 2.66, 95% CI: 2.52–2.82, P < 0.001). Risk of ischemic stroke(13.5% vs. 11.1%, 12.0%, 14.0%) was similar, however risk of hemorrhagic stroke was significantly higher among patients receiving warfarin(1.2%) compared to patients receiving dabigatran(0.5%), rivaroxaban(0.7%) and apixaban(0.8%) respectively, P = 0.04. Conclusions We demonstrated the superior safety profile of DOACs compared to warfarin among patients with underlying cancer and AF. Warfarin was associated with higher mortality, similar ischemic stroke risk but higher risk of hemorrhagic stroke. | Abhishek C Sawant Arnav Kumar Wilmon Mccray Sheldon Tetewsky Linda Parone Srilekha Sridhara Meghana Prakash Hiriyur Prakash Gary Tse Tong LIU Nidhi Kanwar Aishwarya Bhardwaj Sahoor Khan Christopher Manion Ankush Lahoti Ashish Pershad Peter Elkin John Corbelli | 2019 | Journal of Geriatric Cardiology2019，16，9： | 2 |
| 5 | LGP2 Downregulates Interferon Production during Infection with Seasonal Human Influenza A Viruses That Activate Interferon Regulatory Factor 3显示文摘 | Meghana Malur Michael Gale Robert M. Krug | 2012 | Journal of Virology2012，，19： | 2 |
| 6 | Animal models in the study of Alzheimer's disease and Parkinson's disease:A historical perspective显示文摘Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling neurodegenerative diseases globally.Both are proteinopathic conditions and while occasionally inherited,are largely sporadic in nature.Although the advances in our understanding of the two have been significant,they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is adequately helpful.Animal models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological research.This review chronicles the development of those models in the context of Alzheimer's and Parkinson's disease,and highlights the shifting paradigms in studying two humanspecific conditions in non-human organisms. | Rajashree Banerjee Arushi Rai Shreyas M.Iyer Sonia Narwal Meghana Tare | 2022 | Animal Models and Experimental Medicine2022，5，1： | 2 |
| 7 | Prognostic Significance of Myocardial Fibrosis in Hypertrophic Cardiomyopathy显示文摘 | Rory O’Hanlon Agata Grasso Michael Roughton James C. Moon Susan Clark Ricardo Wage Jessica Webb Meghana Kulkarni Dana Dawson Leena Sulaibeekh Badri Chandrasekaran Chiara Bucciarelli-Ducci Ferdinando Pasquale Martin R. Cowie William J. McKenna Mary N. Shep | 2010 | Journal of the American College of Cardiology2010，，11： | 2 |
| 8 | Differentiating adenomas from hyperplastic colorectal polyps: narrow-band imaging can be learned in 20 minutes显示文摘 | Meghana Raghavendra David G. Hewett Douglas K. Rex | 2010 | Gastrointestinal Endoscopy2010，，： | 2 |
| 9 | Future of mental health in the metaverse显示文摘The metaverse and non-fungible tokens(NFTs)were some of the hottest tech terms in 2021,according to a Google Trends search.Our review aims to describe the metaverse and NFTs in the context of their potential application in the treatment of mental health disorders.Advancements in technology have been changing human lives at an ever-increasing pace.Metaverse,also known as the threedimensional(3D)internet,is the convergence of virtual reality(VR)and physical reality in a digital space.It could potentially change the internet as we know it,with NFTs as the key building blocks in the new expansive virtual ecosystem.This immersive 3D virtual world boasts the features of the real world with the added ability to change the surrounding environment according to individual needs and requirements.VR,augmented reality(AR)and mixed reality(MR)have been employed as tools in the treatment of various mental health disorders for the past decade.Studies have reported positive results on their effectiveness in the diagnosis and treatment of mental health disorders.VR/AR/MR have been hailed as a solution to the acute shortage of mental health professionals and the lack of access to mental healthcare.But,on the flip side,young adults tend to spend a significant amount of time playing 3D immersive games and using social media,which can lead to insecurity,anxiety,depression,and behavioural addiction.Additionally,endless scrolling through social media platforms negatively affects individuals'attention span as well as aggravating the symptoms of adolescents with attention deficit hyperactivity disorder.We aimed to explore the ramifications of expanding applications of the metaverse on mental health.So far,no other review has explored the future of mental health in the context of the metaverse. | Sadia Suhail Usmani Medha Sharath Meghana Mehendale | 2022 | General Psychiatry2022，35，4： | 1 |
| 10 | An ionic liquid influenced L-proline catalysed asymmetric michael addition of ketones to nitrostyrene 显示文摘 | Meghana S R Mahesh K P Swapnil S M | 2005 | J Mol Catal A:Chem2005，235，： | 1 |
| 11 | Does FDI facilitate domestic entry? Evidence from the Czech Republic显示文摘 | Meghana Ayyagari and Renáta Kosová | 2010 | Review of International Economics18(1):14-292010，，： | 1 |
| 12 | Drug utilization evaluation of medications used in the management of neurological disorders显示文摘Background and object:The burden of neurological disorders in India is expected to increase due to the rapid demographic and epidemiological transition,with irrational drug use,which is also a global concern.Thus,drug utilization evaluation is designed to ensure appropriate medicine use within the healthcare settings.The aim of the study was to assess the rate and pattern of drug utilization in the management of neurological disorders.Materials and methods:A hospital-based cross-sectional drug utilization evaluation study on neurological drugs was carried out at the Department of Neurology over a span of six months.All legible prescriptions consisting neurological medications irrespective of patient's gender,aged≥18 years were included for the study.The World Health Organization(WHO)core drug use indicators were used to assess the drug prescribing and utilization patterns.Results:A total of 310 prescriptions were reviewed,where male predominance was found to be 56.45%.Out of 310 prescriptions,drugs belonging to 26 neurological classes were prescribed for the management of various neurological disorders.The majority of patients were diagnosed with epilepsy and the most prescribed drugs per patient were phenytoin(14.8%)and valproic acid(6.45%).By following the WHO core drug prescribing indicators,65.47%of drugs prescribed from the India National List of Essential Medicines,2022,followed by 29.83%of drugs prescribed in generic name and 10.86%of prescriptions including injections.Conclusion:The study findings showed that the prescribing pattern in the Department of Neurology was in accordance with the WHO core prescribing indicators.But,the extent of polypharmacy prescriptions was very high.Therefore,interventions are very necessary to promote rational drug prescribing patterns and thus clinical pharmacists can contribute to assess and review the drug utilization pattern to optimize the drug therapy and improvement in patient safety. | Meghana Upadhya Nivya Jimmy Jesslyn Maria Jaison Shahal Sidheque Harsha Sundaramurthy Nemichandra S c Shasthara Paneyala Madhan Ramesh Jehath Syed Nikita Pal Sri Harsha Chalasani | 2023 | Global Health Journal2023，7，3： | 1 |
| 13 | Does cross-listingfacilitate changes in corporate ownership and control?显示文摘 | Meghana Ayyagari Craig Doidge | 2010 | Journal of Banking&Finance2010，，34： | 1 |
| 14 | Firm Innovation in Emerging Markets: The Role of Finance, Governance, and Competition显示文摘 | Meghana Ayyagari Asli Demirgü?-Kunt Vojislav Maksimovic | 2011 | Journal of Financial and Quantitative Analysis2011，，6： | 1 |
| 15 | Activity of water-soluble turmeric extract using hydrophilic excipients显示文摘 | Suhit Gilda Meghana Kanitkar Ramesh Bhonde Anant Paradkar | 2009 | LWT - Food Science and Technology2009，，1： | 1 |
| 16 | Glass wool tripod foreign bodies in the eye : first ever reported case series 显示文摘 | Baile RB Meghana SC Pattiwar MS | 2014 | Middle East Afr J Ophthalmol2014，21，4： | 1 |
| 17 | Convenient and efficient protocols for coumarin synthesis viaPechmann condensation in neutral ionic liquids显示文摘 | Potdar Mahesh Rasalkar Meghana Mohile Swapnil | 2005 | Journal ofMolecular Catalysis A:Chemical2005，235，12： | 1 |
| 18 | Small and Medium Enterprises across the Globe 显示文摘 | Ayyagari Meghana Thorsten Beck Asli Demirg - Kunt | 2007 | Small Business Economics2007，29，4： | 1 |
| 19 | GRADE证据质量评级及其在循证实践中的重要性显示文摘引言循证实践是现代医学实践中不可或缺的一部分,忽视证据和证据质量的现代医疗是无法想象的1.然而,循证医学并不像人们认为的那样完美。在当代研究中,学者们总是会对证据质量提出质疑。《柳叶刀》杂志总编理查德·霍顿(Richard Horton)曾在《柳叶刀》上发文指出,由于纳人研究样本量较小、研究差异无统计学意义、分析方法不恰当、利益冲突明显、或对流行趋势的盲从等因素,近50%的科学文献可能存在错误或造假2。 | Anil Kumar Meghana Taggarsi 王瑞(译) 张崇凡(译) 夏君(译) | 2021 | 英国医学杂志中文版2021，24，2： | 1 |
| 20 | Lexical chains using distributional measures of concept distance 显示文摘 | Meghana Marathe Graeme Hirst | 2010 | Lecture Notes in Computer Science2010，6008，： | 1 |
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