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| 1 | Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage显示文摘Objective Intracerebral hemorrhage(ICH)refers to predominant,sporadic,and non-traumatic bleeding in the brain parenchyma.The PI3K/AKT/mTOR signaling pathway is an important signal transduction pathway regulated by enzyme-linked receptors and has many biological functions in mammals.It plays a key role in neuronal metabolism,gene expression regulation,and tissue homeostasis in the healthy and diseased brain.Methods In the present study,the role of the PI3K/AKT/mTOR pathway inhibitor chrysophanol(CPH)(10 mg/kg and 20 mg/kg,orally)in the improvement of ICH-associated neurological defects in rats was investigated.Autologous blood(20µL/5 min/unilateral/intracerebroventricular)mimics ICH-like defects involving cellular and molecular dysfunction and neurotransmitter imbalance.The current study also included various behavioral assessments to examine cognition,memory,and motor and neuromuscular coordination.The protein expression levels of PI3K,AKT,and mTOR as well as myelin basic protein and apoptotic markers,such as Bax,Bcl-2,and caspase-3,were examined using ELISA kits.Furthermore,the levels of various neuroinflammatory cytokines and oxidative stress markers were assessed.Additionally,the neurological severity score,brain water content,gross brain pathology,and hematoma size were used to indicate neurological function and brain edema.Results CPH was found to be neuroprotective by restoring neurobehavioral alterations and significantly reducing the elevated PI3K,AKT,and mTOR protein levels,and modulating the apoptotic markers such as Bax,Bcl-2,and caspase-3 in rat brain homogenate.CPH substantially reduced the inflammatory cytokines like interleukin(IL)-1β,IL-6,and tumor necrosis factor-α.CPH administration restored the neurotransmitters GABA,glutamate,acetylcholine,dopamine,and various oxidative stress markers.Conclusion Our results show that CPH may be a promising therapeutic approach for overcoming neuronal damage caused by the overexpression of the PI3K/AKT/mTOR signaling pathway in ICH-induced neurological dysfunctions in rats. | Kuldeep Singh JADAUN Sidharth MEHAN Aarti SHARMA Ehraz Mehmood SIDDIQUI Sumit KUMAR NaifALSUHAYMI | 2022 | Current Medical Science2022，42，2： | 5 |
| 2 | 城市设计促进环境文化(英文)显示文摘过去30年里,欧洲的工业生产体系逐步从高度集中于工业区的福特主义向分散制造的后福特主义转变。随着这种转型,西方国家城市普遍出现旧工业区。这些地方依然有着潜在的经济价值,但荒废弃置阻碍了这些价值的发挥。为释放其经济价值,迫切需要以保护和循环利用的策略来取代拆迁和重建。自20世纪70年代以来,工业遗产地的实验性更新策略已成为设计实践的保留节目。文章通过对德国鲁尔河谷埃姆歇公园、荷兰阿姆斯特丹废弃旧港区NDSM码头和Sulzerareal——一座位于瑞士Winterthur的旧钢铁联合企业——3个案例的批判性对比,提出讨论'自适应再利用'方法。这些设计通过实验性的新替代策略实现工业区的更新,尽量减少必须的干预和激活长周期过程,与完全修复相比,这显得更有效率也更经济。这个过程通常始于大片场地中一小块剩余场地的物质性修复,从而引发周围环境和城市关系的改进。这种方法通常提高地区的可达性,增加其孔隙度和均质性,避免产生与毗邻用地没有联系的社会隔离的飞地。这也可能激活与该地区有影响力的正式或非正式社会组织协商的进程,实践以人为本的治理和问责。这一转型进程吸引或排斥哪些人,他们的水平如何,将决定新的市民中心能否巩固,也关乎后工业时代的身份认同。除了物质空间影响之外,对这些转型的分析突出了该进程对社会融合、生态和文化意识的提升的影响,这些都是环境转型中的关键问题。 | Maria Paola Repellino Laura Martini Asma Mehan | 2016 | 南方建筑2016，，2： | 3 |
| 3 | Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders显示文摘Long term suppression of succinate dehydrogenase by selective inhibitor 3-nitropropionic acid has been used in rodents to model Huntington's disease where mitochondrial dysfunction and oxidative damages are primary pathological hallmarks for neuronal damage. Improvements in learning and memory abilities, recovery of energy levels, and reduction of excitotoxicity damage can be achieved through activation of Adenyl cyclase enzyme by a specific phytochemical forskolin. In this study, intraperitoneal administration of 10 mg/kg 3-nitropropionic acid for 15 days in rats notably reduced body weight, worsened motor cocordination(grip strength, beam crossing task, locomotor activity), resulted in learning and memory deficits, greatly increased acetylcholinesterase, lactate dehydrogenase, nitrite, and malondialdehyde levels, obviously decreased adenosine triphosphate, succinate dehydrogenase, superoxide dismutase, catalase, and reduced glutathione levels in the striatum, cortex and hippocampus. Intragastric administration of forskolin at 10, 20, 30 mg/kg dose-dependently reversed these behavioral, biochemical and pathological changes caused by 3-nitropropionic acid. These results suggest that forskolin exhibits neuroprotective effects on 3-nitropropionic acid-induced Huntington's disease-like neurodegeneration. | Sidharth Mehan Shaba Parveen Sanjeev Kalra | 2017 | Neural Regeneration Research2017，12，2： | 2 |
| 4 | Management of drought stress to improve field screening of peanut for resistance to Aspergillus 显示文摘 | Mehan V K Rao R C N McDonald | 1988 | Phytopathology1988，78，6： | 1 |
| 5 | Adenylate cyclase activator forskolin alleviates intracerebroventricular propionic acid-induced mitochondrial dysfunction of autistic rats显示文摘Neuronal mitochondrial dysfunction increases inflammatory mediators and leads to free radical generation and anti-oxidant enzymatic alterations,which are major neuropathological hallmarks responsible for autism.Mitochondrial dysfunction in autism is associated with decreased ATP levels due to reduced levels of cyclic adenosine monophosphate.Rat models of autism were established by intracerebroventricular injection of propionic acid.These rat models had memory dysfunction,decreased muscle coordination and gait imbalance.Biochemical estimation of propionic acid-treated rats showed changes in enzyme activity in neuronal mitochondrial electron transport chain complexes and increases in pro-inflammatory cytokines,oxidative stress and lipid biomarkers.Oral administration of 10,20 and 30 mg/kg adenylate cyclase activator forskolin for 15 days reversed these changes in a dose-dependent manner.These findings suggest that forskolin can alleviate neuronal mitochondrial dysfunction and improve neurological symptoms of rats with autism.This study was approved by the RITS/IAEC,SIRSA,HARYANA on March 3,2014(approval No.RITS/IAEC/2014/03/03). | Sidharth Mehan Saloni Rahi Aarti Tiwari Tarun Kapoor Kajal Rajdev Ramit Sharma Himanshi Khera Sourabh Kosey Umesh Kukkar Rajesh Dudi | 2020 | Neural Regeneration Research2020，15，6： | 1 |
| 6 | Clinical stroke penumbra: use of National Institutes of Health stroke scale as a surrogate for CTperfusion in patient triage for intra-arterial middle cerebral artery stroke therapy显示文摘 | Boxerman JL Jayaraman MV Mehan WA | 2012 | AJNR Am J Neuroradiol2012，33，10： | 1 |
| 7 | Cisplatin versus cctuxi- mab given concurrently with definitive radiation therapy for locally advanced head and neck squamous cell carcinoma显示文摘 | LEY J MEHAN P WILDEST M | 2013 | Oncology2013，85，5： | 1 |
| 8 | Plasma cell leukemia:A SEER database analysis 显示文摘 | Ramsingh G Mehan P Luo J | 2009 | J C fin Onco12009，，： | 1 |
| 9 | The Importance of Serum Procalcitonin in Diagno- sis and Treatment of Serious Bacterial Infections and Sepsis显示文摘 | Mehanic S Baljic R | 2013 | Mater Sociomed2013，25，4： | 1 |
| 10 | Solid state SiC/Ni alloy reaction显示文摘 | Jackson M R Mehan R L Davics A M | 1983 | Metall Trans1983，14，： | 1 |
| 11 | Groundnut cultivars with seed resistant to invasion by Aspergillus flaws 显示文摘 | Mehan V K Donald D Mc Nigam S N | | Oleagineux0，36，10： | 1 |
| 12 | Laparoscopic variocelectomy: preliminary report of a new technique显示文摘 | Hagood PG Mehan DJ Worischeck JH | 1992 | J Urol1992，147，1： | 1 |
| 13 | Effect of SiC content and orientation on the properties of Si/SiC ceramic composite显示文摘 | | 1978 | J Mater Sci1978，13，2： | 1 |
| 14 | Laparoscopic vari- coceleetomy: preliminary report of a new technique 显示文摘 | Hagood PG Mehan D J Worischeck JH | 1992 | J Urol1992，147，1： | 1 |
| 15 | Brucella endocarditis in prosthetic valves显示文摘 | MehanicS MulabdicV BaljicR | 2012 | Mater Sociomed2012，24，1： | 1 |
| 16 | Amel- ioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine - a PDE1 inhibitor 显示文摘 | Deshmukh R Sharma V Mehan S Sharma N Bedi KL | 2009 | Eur J Pharmacol2009，620，13： | 1 |
| 17 | Delayed gadolinium-enhanced MR imaging of eartilage(dGEMRIC) following ACL injury显示文摘 | Fleming BC Oksendahl HL Mehan WA | 2010 | Osteoarthriti~ Cartilage2010，18，5： | 1 |
| 18 | Laparoscopic varicocelectomy:Preliminary report of a new technique显示文摘 | Hagood PG Mehan DJ Worischeck JH | 1992 | J Urol1992，147，： | 1 |
| 19 | Microcomputers in Classrooms: Educational Technology or Social Practice显示文摘 | Mehan ll | 1989 | Anthropology & Education Quarterly1989，20，1： | 1 |
| 20 | Tinnitus as the presenting symptom in a case of Lhermitte-Duclos disease 显示文摘 | Lobo CJ Mehan R Murugasu E | 1999 | J Laryngol Otol1999，113，： | 1 |
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