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| 1 | Biopsy-driven diagnosis in infants with cholestatic jaundice in Iran显示文摘AIM:To determine the frequencies of diagnoses confirmed by liver biopsy in infants with cholestasis in an Iranian pediatric hospital.METHODS:This was a retrospective study conducted in a tertiary referral children’s hospital in Iran.We retrieved all pathology reports of liver biopsies from children less than two years of age who had presented for evaluation of cholestatic jaundice from March 2001to March 2011.Additional specimen samples obtained from archived pathology blocks were reviewed by a pathologist blinded to the final diagnosis.These results were compared with the pathology reports from chart records to ensure consensus and eliminate any inconsistencies in final diagnoses.A structured checklist was used to gather information on multiple variables including age,sex,gestational age at birth,birth weight,age at which hyperbilirubinemia manifested,presence and identification of associated anomalies,clinical manifestations,and histological findings from liver biopsies.The baseline data are reported using descriptive statistics,and differences between groups were assessed by Fisher’s exact test and Student’s t test when indicated.RESULTS:Fifty-five cases(28 females;27 males)of infantile cholestasis(IC)were included in this study.The mean serum total bilirubin and direct bilirubin at presentation were 13.6±5.9 and 7.3±3.4,respectively.Forty cases(72.7%)were the product of term pregnancies.Common associated clinical findings were acholic stool in 33 cases(60.0%),hepatomegaly in30 cases(54.5%),and dark-colored urine in 21 cases(38.2%).Biliary atresia(BA)was the most frequent diagnosis,found in 32 cases(58.2%),followed by intrahepatic bile duct paucity found in 6 cases(10.9%),metabolic disease in 6 cases(10.9%),idiopathic neonatal hepatitis in 5 cases(9.1%),choledochal cyst in2 cases(3.6%),liver cirrhosis in 2 cases(3.6%),and progressive familial intrahepatic cholestasis and portal fibrosis each in 1 case(1.8%).The mean times for jaundice onset and liver biopsy were 43.8 and 102.0 d,respectively.In BA,the mean age at jaundice presentation was 21 d and for liver biopsy was 87.5 d,representing a mean delay of 66.5 d.CONCLUSION:A significant delay was found between IC presentation and liver biopsy,which is detrimental in conditions that can cause irreversible liver damage,such as BA. | Elham Talachian Ali Bidari Mitra Mehrazma Nahid Nick-khah | 2014 | World Journal of Gastroenterology2014，20，4： | 3 |
| 2 | The value of serum uric Acid as a mortality prediction in critically ill children 显示文摘 | Hooman N Mehrazma M Nakhaii S | 2010 | IranJ Pediatr2010，20，3： | 1 |
| 3 | Changes in structure,interstitial cajal-like cells and apoptosis of smooth muscle cells in congenital ureteropelvic junction obstruction显示文摘 | Mehrazma M Tanzifi P Rakhshani N | 2014 | Iran J Pediatr2014，24，1： | 1 |
| 4 | Clinicopathologic Correlations in He- noch-Schonlein Nephritis显示文摘 | Nicka A Mehrazma M Lahouti A | 2012 | Iran J Kidney Dis2012，6，6： | 1 |
| 5 | Changes in Structure, In- terstitial Cajal - like Cells and Apoptosis of Smooth Muscle Cells in Congenital Ureteropelvic Junction Obstruction 显示文摘 | Mehrazma M Tanzifi P Rakhshani N | 2014 | Iran J Pediatr2014，24，1： | 1 |
| 6 | The value of serum uric acid as a mortality prediction in critically ill children显示文摘 | Hooman N Mehrazma M Nakhaii S | 2010 | Iran J Pediatr2010，20，： | 1 |
| 7 | Changes in Structure, Interstitial Cajal-like Ceils and Apoptosis of Smooth Muscle Ceils in Congerital Ureteropelvic Junction Obstruction 显示文摘 | Mehrazma M 'l'anzit P Rakhshani N | 2014 | Iran J Pediatr2014，24，1： | 1 |
| 8 | Clinicopathologic correlations in Henoch-Sch(o)nlein nephritis显示文摘 | Nickavar A Mehrazma M Lahouti A | | 0，，06： | 1 |
| 9 | Prognostic value of renalpathological findings in children with atypical hemolytic uremic syn-drome显示文摘 | Mehrazma M Hooman N Otukesh H | 2011 | Iran J Kidney Dis2011，5，6： | 1 |
| 10 | The influence of solvent on the performance of Pt-Sn/0-A12 03 propane dehy- drogenation catalyst prepared by co-impregnation method 显示文摘 | Zangeneh F T Mehrazma S Sahebdelfar S | 2013 | Fuel Processing Technology2013，109，： | 1 |
| 11 | Expression of Ki- 67, p53 and VEGF in pediatric neuroblastoma 显示文摘 | Gheytanchi E Mehrazma M Madjd Z | 2014 | Asian Pac J Cancer Prev2014，15，7： | 1 |
| 12 | Clincopathologiccorrelations in Henoch Schonlein nephritis显示文摘 | Nickavar A Mehrazma M Lahouti A | 2012 | Iran J Kidney Dis2012，6，6： | 1 |
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