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| 1 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 2 | Fish oil-based lipid emulsions prevent and reverse parenteral nutrition-associated liver disease: The Boston Experience 显示文摘 | de Meijer VE Gura KM Le HD | 2009 | JPEN J Parenter Enteral Nutr2009，33，5： | 1 |
| 3 | Parenteral fish-oil- based lipid emulsion improves fatty acid profiles and lipid in parenteral nutrition-dependent children显示文摘 | Le HD Meijer VE Robinson EM | 2011 | Am J Clin Nutr2011，94，3： | 1 |
| 4 | Cell cycle and molecular targets : CDK inhibition 显示文摘 | Carassou P Meijer L Le Moulec SA | 2012 | Bull Cancer2012，99，2： | 1 |
| 5 | Human papillomavirus genotype attribution in invasive cervical cancer:a retrospective cross-sectional worldwide study显示文摘 | de Sanjose S Quint WG Alemany L Geraets DT Klaustermeier JE Lloveras B Tous S Felix A Bravo LE Shin HR Vallejos CS de Ruiz PA Lima MA Guimera N Clavero O Alejo M Llombart-Bosch A Cheng-Yang C Tatti SA Kasamatsu E Iljazovic E Odida M Prado R Seoud M Grce M Usubutun A Jain A Suarez GA Lombardi LE Banjo A Menéndez C Domingo EJ Velasco J Nessa A Chichareon SC Qiao YL Lerma E Garland SM Sasagawa T Ferrera A Hammouda D Mariani L Pelayo A Steiner I Oliva E Meijer CJ AlJassar WF Cruz E Wright TC Puras A Llave CL Tzardi M Agorastos T Garcia-Barriola V Clavel C Ordi J Andújar M Castellsagué X Sánchez GI Nowakowsld AM Bornstein J Mu(n)oz N Bosch FX Retrospective International Survey and HPV Time Trends Study Group | 2010 | Lancet Oncol2010，11，11： | 1 |
| 6 | Water content, organic carbon and dry bulk density in flooded sediments 显示文摘 | Avnimelech Y Ritvo G Meijer LE Kochba M | 2001 | Aquacult Eng2001，25，： | 1 |
| 7 | Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model显示文摘 | Vincent E. de Meijer Hau D. Le Jonathan A. Meisel M. Reza Akhavan Sharif Amy Pan Vania Nosé Mark Puder | 2010 | Metabolism2010，，8： | 1 |
| 8 | Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas显示文摘 | van Houten VM Snijders PJ van den Brekel MW Kummer JA Meijer CJ van Leeuwen B Denkers F Smcele LE Snow GB Brakenhoff RH | 2001 | Int J Cancer2001，93，2： | 1 |
| 9 | Calcitonin and carcinoembryonic antigen doubling times asprognostic factors in- medullary thyroid carcinoma : a structured meta-analysis 显示文摘 | Meijer JA le Cessie S van den FIout WB | 2010 | Clin Endocrinol2010，72，4： | 1 |
| 10 | Dietary fat in- take promotes the development of hepatic steatosis independ- ently from excess caloric consumption in a murine model 显示文摘 | de Meijer V E Le H D Meisel J A | 2010 | Metabolism2010，59，8： | 1 |
| 11 | Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model显示文摘 | de Meijer V E Le H D Meisel J A | 2010 | Metabolism2010，59，8： | 1 |
| 12 | Cell cycle and molecular targets: CDK inhibition显示文摘 | Carassou P Meijer L Le Moulec S | 2012 | Bull Cancer2012，99，： | 1 |
| 13 | Parenteral fish-oil- based lipid emulsion improves fatty acid profiles and lipids in parenteral nutrition-dependent children 显示文摘 | Le HD de Meijer VE Robinson EM | 2011 | Am J Clin Nutr2011，94，2： | 1 |
| 14 | A killer on the road:circulating CD4(+)CD28null T cells as cardiovascular risk factorin ESRD patients显示文摘 | Betjes MG Meijers RW de Wit LE | 2012 | J Nephrol2012，25，2： | 1 |
| 15 | Innovative parenteral and enteral nutrition therapy for intestinal failure 显示文摘 | Le H D Fallon E M de Meijer V E | 2010 | Semin Pediatr Surg2010，19，1： | 1 |
| 16 | Epide miological and virological assessment of influenza ac tivity in Europe during the winter 2005 ~ 2006显示文摘 | Meijer A Meerhoff TJ Meuwissen LE | 2007 | Euro Surveillance2007，12，9： | 1 |
| 17 | Calcitonin andcarcinoembryonic antigen doubling times as prognostic factorsin medullary thyroid carcinoma:a structured meta-analysis显示文摘 | Meijer JA le Cessie S van den Hout WB eta l | 2010 | Clin Endocrinol(Oxf)2010，72，4： | 1 |
| 18 | Calcitoninand carcinoembryonic antigen doubling times as prognos-tic factors in medullary thyroid carcinoma:a structuredmeta-analysis显示文摘 | Meijer JA le Cessie S van den Hout WB | 2010 | Clin Endocrinol2010，72，4： | 1 |
| 19 | Calcitonin and carcinoembryonic antigen doubling times as prognostic factors in medullary thyroid carcinoma: a structured meta-analysis 显示文摘 | Meijer JA le Cessie S van den Hout WB | 2010 | Clin Endocrinol2010，72，4： | 1 |
| 20 | Radioactive iodine in the treatment of medullary thyroid carcinoma: a controlled multicenter study 显示文摘 | Meijer JA Bakker LE Valk GD | 2013 | Eur J Endocrinol2013，168，5： | 1 |
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