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| 1 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 2 | Epothilones: quantitative structure activity relations studied by support vector machines and artificial neural networks显示文摘 | Bleckmann A Meiler J | 2003 | Quant Struct Act Relat(comb)2003，22，： | 1 |
| 3 | Fast determination of ^13 CNMR chemical shifts using artificial neural networks 显示文摘 | Meiler J Meusinger R Will M | 2000 | J Chem Inf Comp Sci2000，0，1： | 1 |
| 4 | State-of-health monitoring of lithium-ion batteries in electric vehicles by on-board internal resistance estimation显示文摘 | Remmlinger J Buchholz M Meiler M | | 0，，12： | 1 |
| 5 | Genius:a genetic algorithm for automated structure elucidation from 13C NMR spectra显示文摘 | Meiler J Will M | | 0，，9： | 1 |
| 6 | Fast determination of 13C NMR chemical shifts using artificial neural networks显示文摘 | Meiler J Meusinger R Will M | 2000 | J Chem Inf Comp Sci2000，40，： | 1 |
| 7 | State-of-health monitoring of lithium-ion batterys inelectric vehicles by on-board internal resistanceestimation显示文摘 | Remmlinger J Buchholz M Meiler M | 2001 | Journal of Power Source2001，1969，12： | 1 |
| 8 | Fast determination of ^13C NMR chemical shifts using artificial neural networks 显示文摘 | Meiler J Meusinger R Will M | 2000 | J Chem Inf Comput Sci2000，40，1： | 1 |
| 9 | State-of-health monitoring of lithium-ion batteries in electric vehicles by on-board internal resistance estimation显示文摘 | Remmlinger J Buchholz M Meiler M | 2011 | Journal of Power Sources2011，196，12： | 1 |
| 10 | Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides 显示文摘 | Li F Xia Y Meiler J | 2013 | Biochemistry2013，52，： | 1 |
| 11 | Fast Determination of 13C NMR Chemical Shifts Using Artificial Neural Networks显示文摘 | Meiler J Meusinger R Will M | 2000 | J Chem Inf Comput Sci2000，40，： | 1 |
| 12 | In vivo switch to IL- 10 secreting T regulatory cells in high dose allergen exposure显示文摘 | Meiler F Zumkehr J Klunker S | 2008 | J Exp Med2008，205，： | 1 |
| 13 | Rosetta predictions in CASP5 :successes, failures, and prospects for complete automation 显示文摘 | Bradley P Chivian D Meiler J | 2003 | Proteins2003，53，6： | 1 |
| 14 | Strand-loop-strand motifs: prediction of hairpins and diverging turns in proteins 显示文摘 | Kuhn M Meiler J Baker D | 2004 | Proteins2004，54，： | 1 |
| 15 | In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure显示文摘 | Meiler F Zumkehr J Klunker S | | 0，，12： | 1 |
| 16 | Fast determination of ^13CNMR chemical shifts using artificial neural networks 显示文摘 | Meiler J Meusinger R Will M | 2000 | J Chem Inf Comput Sci2000，40，： | 1 |
| 17 | 18 F-FDG PET and PET/CT in fever of unknown origin显示文摘 | MEILER J SAHLMANN C O SCHEEL A K | 2007 | J Nucl Med2007，48，1： | 1 |
| 18 | State-of-health monitoring of lithium-ion batteries in electric vehicles by on-board internal resistance estimation显示文摘 | Remmlinger J Buchholz M Meiler M | 2011 | Journal of Power Sources2011，196，12： | 1 |
| 19 | State-of-health monitoring of lithium-ion batteries inelectric vehicles by on-board internal resistance estimation显示文摘 | Remmlinger J Buchholz M Meiler M | 2001 | Journal of Power Sources2001，196，12： | 1 |
| 20 | State-of-health monitoring of lithium-ion batteries in electric vehicles by on-board internal resistance estimation 显示文摘 | REMMLINGER J BUCHHOLZ M MEILER M | 2011 | Journal of Power Sources2011，196，12： | 1 |
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