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| 1 | Radical scavenging, antioxidant and cytotoxic activity of Brazilian Caatinga plants 显示文摘 | David J P Meira M David J M | 2007 | Fitoterapia2007，78，3： | 1 |
| 2 | Non-intrusive signature extraction for major residential loads显示文摘 | Dong M Meira P Wilsun X | 2013 | IEEE Transactions on Smart Grid2013，4，3： | 1 |
| 3 | An eventwindow based load monitoring technique for smartmeters显示文摘 | MING D MEIRA P C M WILSUN X | 2012 | IEEE Trans on Smart Grid2012，3，2： | 1 |
| 4 | Trypanosoma cruzi trans-sialidase prevents elicitation of Th1 cell response via inter?leukin 10 and downregulates Th1 effector cells显示文摘 | Ruiz Diaz P Mucci J Meira MA | 2015 | Infect Im?m un2015，83，5： | 1 |
| 5 | An event win- dow based load monitoring technique for smart meters显示文摘 | Ming Dong Meira P C M Wilsun Xu et ol | 2012 | IEEE Trans on Smart Grid2012，3，2： | 1 |
| 6 | Detection of Helicobacter pylori resistance to clarithromycin and fluoroquinolones in Brazil:A national survey显示文摘AIM To evaluate bacterial resistance to clarithromycin and fluoroquinolones in Brazil using molecular methods.METHODS The primary antibiotic resistance rates of Helicobacter pylori(H. pylori) were determined from November 2012 to March 2015 in the Southern,South-Eastern,Northern,North-Eastern,and Central-Western regions of Brazil. Four hundred ninety H. pylori patients [66% female,mean age 43 years(range: 18-79)] who had never been previously treated for this infection were enrolled. All patients underwent gastroscopy with antrum and corpus biopsies and molecular testing using Geno Type Helico DR(Hain Life Science,Germany). This test was performed to detect the presence of H. pylori and to identify point mutations in the genes responsible for clarithromycin and fluoroquinolone resistance. The molecular procedure was divided into three steps: DNA extraction from the biopsies,multiplex amplification,and reverse hybridization. RESULTS Clarithromycin resistance was found in 83(16.9%) patients,and fluoroquinolone resistance was found in 66(13.5%) patients. There was no statistical difference in resistance to either clarithromycin or fluoroquinolones(P = 0.55 and P = 0.06,respectively) among the different regions of Brazil. Dual resistance to clarithromycin and fluoroquinolones was found in 4.3%(21/490) of patients. The A2147 G mutation was present in 90.4%(75/83),A2146 G in 16.9%(14/83) and A2146 C in 3.6%(3/83) of clarithromycin-resistant patients. In 10.8%(9/83) of clarithromycin-resistant samples,more than 01 mutation in the 23 S r RNA gene was noticed. In fluoroquinolone-resistant samples,37.9%(25/66) showed mutations not specified by the Geno Type Helico DR test. D91 N mutation was observed in 34.8%(23/66),D91 G in 18.1%(12/66),N87 K in 16.6%(11/66) and D91 Y in 13.6%(9/66) of cases. Among fluoroquinolone-resistant samples,37.9%(25/66) showed mutations not specified by the Geno Type Helico DR test. CONCLUSION The H. pylori clarithromycin resistance rate in Brazil is at the borderline(15%-20%) for applying the standard triple therapy. The fluoroquinolone resistance rate(13.5%) is equally concerning. | Bruno Squarcio Sanches Gustavo Miranda Martins Karine Lima Bianca Cota Luciana Dias Moretzsohn Laercio Tenorio Ribeiro Helenice P Breyer Ismael Maguilnik Aline Bessa Maia Joffre Rezende-Filho Ana Carolina Meira Henrique Pinto Edson Alves Ramiro Mascarenhas Raissa Passos Julia Duarte de Souza Osmar Reni Trindade Luiz Gonzaga Coelho | 2016 | World Journal of Gastroenterology2016，22，33： | 1 |
| 7 | Mitochondrially-mediated toxicity of bile acids 显示文摘 | Pa|meira C M Rolo A P | 2004 | Toxicology2004，203，13： | 1 |
| 8 | An event window based load monitoring technique for smart meters显示文摘 | DONG Ming MEIRA P C M XU Wilsun | 2012 | IEEE Trans on Smart Grid2012，3，2： | 1 |
| 9 | Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model显示文摘AIM To evaluate the anti-inflammatory intestinal effect of the ethanolic extract(EtO HE) and hexane phase(HexP) obtained from the leaves of Combretum duarteanum(Cd).METHODS Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS Both Cd-Et OHE and Cd-Hex P caused significant reductions in macroscopic lesion scores and ulcerative l e sionareas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-α and IL-1β. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide dismutase. CONCLUSION The data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease. | Gedson Rodrigues de Morais Lima Flavia Danniele Frota MachadoLarissa Lucena Périco Felipe Meira de Faria Anderson Luiz-Ferreira Alba Regina Monteiro Souza Brito Cláudia Helena Pellizzon Clélia Akiko Hiruma-Lima Josean Fechine Tavares JoséMaria Barbosa Filho LeOnia Maria Batista | 2017 | World Journal of Gastroenterology2017，23，8： | 1 |
| 10 | Radical scavenging, antioxidant and cytotoxic activity of Brazilian Caatinga plants显示文摘 | Juceni P David Marilena Meira Jorge M David | 2007 | Fitoterapia2007，78，： | 1 |
| 11 | Trends and predictions for gastric cancer mortality in Brazil显示文摘AIM: To analyze the effect of age-period and birth cohort on gastric cancer mortality, in Brazil and across its five geographic regions, by sex, in the population over 20 years of age, as well as make projections for the period 2010-2029.METHODS: An ecological study is presented herein,which distributed gastric cancer-related deaths in Brazil and its geographic regions. The effects of ageperiod and birth cohort were calculated by the Poisson regression model and projections were made with the age-period-cohort model in the statistical program R. RESULTS: Progressive reduction of mortality rates was observed in the 1980's, and then higher and lower mortality rates were verified in the 2000's, for both sexes, in Brazil and for the South, Southeast and Midwest regions. A progressive decrease in mortality rates was observed for the Northeast(both sexes) and North(men only) regions within the period 1995-1999, followed by rising rates. CONCLUSION: Regional differences were demonstrated in the mortality rates for gastric cancer in Brazil, and the least developed regions of the country will present increases in projected mortality rates. | Angela Carolina Brandao de Souza Giusti Pétala Tuani Candido de Oliveira Salvador Juliano dos Santos Karina Cardoso Meira Amanda Rodrigues Camacho Raphael Mendonca Guimaraes Dyego LB Souza | 2016 | World Journal of Gastroenterology2016，22，28： | 0 |
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