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| 1 | Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines显示文摘Objective: Oxidative stress is linked to increased risk of gastric cancer and matrix metalloproteinases (MMPs) are important in the invasion and metastasis of gastric cancer. We aimed to analyze the effect of the accumulation of oxidative stress in the gastric cancer MKN-45 and 23132/87 cells following hydrogen peroxide (H 2 O 2 ) exposure on the expression patterns of MMP-1, MMP-3, MMP-7, MMP-9, MMP-10, MMP- 11, MMP-12, MMP-14, MMP-15, MMP-17, MMP-23, MMP-28, and β-catenin genes. Methods: The mRNA transcripts in the cells were determined by RT-PCR. Following H 2 O 2 exposure, oxidative stress in the viable cells was analyzed by 2',7'-dichlorofluorescein diacetate (DCFH-DA). Caffeic acid phenethyl ester (CAPE) was used to eliminate oxidative stress and the consequence of H 2 O 2 exposure and its removal on the expressions of the genes were evaluated by quantitative real-time PCR. Results: The expressions of MMP-1, MMP-7, MMP-14, MMP-15, MMP-17 and β-catenin in MKN-45 cells and only the expression of MMP-15 in 23132/87 cells were increased. Removal of the oxidative stress resulted in decrease in the expressions of MMP genes of which the expressions were increased after H 2 O 2 exposure. β-catenin, a transcription factor for many genes including MMPs, also displayed decreased levels of expression in both of the cell lines following CAPE treatment. Conclusions: Our data suggest that there is a remarkable link between the accumulation of oxidative stress and the increased expressions of MMP genes in the gastric cancer cells and MMPs should be considered as potential targets of therapy in gastric cancers due to its continuous exposure to oxidative stress. | Salih Gencer Anil Cebeci Meliha Burcu Irmak-Yazicioglu | 2013 | Chinese Journal of Cancer Research2013，25，3： | 13 |
| 2 | Central retinal artery occlusion and traumatic optic neuropathy following blunt ocular trauma显示文摘Dear Editor,We are writing to present a case report of central retinal artery occlusion(CRAO)and traumatic optic neuropathy(TON)with immediate visual loss caused by blunt facial trauma with a soccer ball.CRAO is an ophthalmic emergency with an estimated incidence of 10 in 1 million~[1].There are few reported cases of retinal artery occlusion(RAO) | Jasmin Zvornicanin Ferenc Kuhn Meliha Halilbasic Zlatko Musanovic | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 3 |
| 3 | Development of Chromium(Ⅲ)-selective Potentiometric Sensor by Using Synthesized Pyrazole Derivative as an lonophore in PVC Matrix and its Applications显示文摘A novel poly(vinyl chloride)membrane potentiometric sensor for chromium(Ⅲ)ions based on the use of 5,5′-(1,4-phenylene)bis(3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide)as a neutral ionophore was developed.The optimum composition of the best performing membrane contained ionophore,potassium tetrakis(p-chlorophenyl)borate(KTpClPB),dibutyl phthalate(DBP),and poly(vinyl chloride)(PVC)in the ratio of 5.5:1.5:55:38(mg).The sensor exhibits a working concentration range of 1.0×10^(-5)-1.0×10^(-1 )mol L^(−1) and a detection limit of 1.7×10^(-6) mol L^(−1).The sensor shows good selectivity for chromium(III)ions over a number of cations including alkali,alkaline earth,heavy and transition metals.The response time of the sensor is 8 s.In addition,the developed sensor shows good reusability and stability.The sensor operates in the wide pH range of 5.0-11.0.The sensor could be used as an indicator electrode in the quantification of Cr^(3+)ions by potentiometric titration against ethylenediaminetetraacetic acid(EDTA).Finally,this sensor was successfully used for the determination of chromium(III)in commercial water,purification water and wastewater. | Ömer Isildak OguzÖzbek Meliha Burcu Gürdere | 2020 | Journal of Analysis and Testing2020，4，4： | 2 |
| 4 | Worldviews and Turkish Foreign Policy in the Middle East显示文摘 | Meliha Altunisik | 2009 | Foreign Policy(Special Issue on Turkish)2009，，： | 1 |
| 5 | The WNT1^(G177C) mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV显示文摘The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV(OI-XV)has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts.Although such aninfluence was supported by subsequent studies,a mouse model of OI-XV remained to be established.Therefore,we introduced a previously identified disease-causing mutation(G177C)into the murine Wnt1 gene.Homozygous Wnt1^(G177C/G177C)mice were viable and did not display defects in brain development,but the majority of 24-week-old Wnt1^(G177C/G177C)mice had skeletal fractures.This increased bone fragility was not fully explained by reduced bone mass but also by impaired bone matrix quality.Importantly,the homozygous presence of the G177C mutation did not interfere with the osteoanabolic influence of either parathyroid hormone injection or activating mutation of LRP5,the latter mimicking the effect of sclerostin neutralization.Finally,transcriptomic analyses revealed that short-term administration of WNT1 to osteogenic cells induced not only the expression of canonical WNT signaling targets but also the expression of genes encoding extracellular matrix modifiers.Taken together,our data demonstrate that regulating bone matrix quality is a primary function of WNT1.They further suggest that individuals with WNT1 mutations should profit from existing osteoanabolic therapies. | Nele Vollersen Wenbo Zhao Tim Rolvien Fabiola Lange Felix Nikolai Schmidt Stephan Sonntag Doron Shmerling Simon von Kroge Kilian Elia Stockhausen Ahmed Sharaf Michaela Schweizer Meliha Karsak Bjorn Busse Ernesto Bockamp Oliver Semler Michael Amling Ralf Oheim Thorsten Schinke Timur Alexander Yorgan | 2021 | Bone Research2021，9，4： | 1 |
| 6 | Abducens nerve palsy and optic neuritis as initial manifestation in brucellosis显示文摘 | Basak Karakurum Goksel Deniz Yerdelen Mehmet Karatas Aysel Pelit Y.Ziya Demiroglu O. Kizilkilic Meliha Tan1 Okan Toygar | 2006 | Scandinavian Journal of Infectious Diseases2006，，： | 1 |
| 7 | Pretreatment processes of molasses for the utilization in fermentation processes 显示文摘 | Guzide Calik Meliha Berak Fatma Gul Boyaci | 2001 | Engineering and Manufacutring for Biotechnology2001，，： | 1 |
| 8 | Pretreatment processes of molasses for the utilization in fermentation process显示文摘 | Guzide C Meliha B Fatma G | 2001 | Engineering and Manufacturing for Biotechnology2001，，： | 1 |
| 9 | Turkish Policy Toward Israel, Turkey's New World: Changing Dynamics in Turkish Foreign Policy 显示文摘 | Meliha Benli Altunisik | 2009 | Washington Institute for Middle !3ast Policy2009，，： | 1 |
| 10 | Prevalence of endothelial nitric oxide synthase E298D polymorphism in Turkish patients with essential hypertension显示文摘 | Figen Esin Kayhan Meliha Koldemir Penbe Cagatay Cavlan Ciftci Belgin Susleyici-Duman | 2013 | Diabetes & Metabolic Syndrome: Clinical Research & Reviews2013，，： | 1 |
| 11 | Ecological dyeing with some plant pulps on woolen yarn and cationized cotton fabric显示文摘 | Meliha Oktav Bulut Ezgi Akar | 2012 | Journal of Cleaner Produciton2012，32，： | 1 |
| 12 | PERSONALITY, DEPRESSION, AND ANXIETY AS RISK FACTORS FOR CHRONIC MIGRAINE显示文摘 | BASAK KARAKURUM ?ZLEM SOYLU MEHMET KARATAS SEMIH GIRAY MELIHA TAN ZüLFIKAR ARLIER SIBEL BENLI | 2004 | International Journal of Neuroscience2004，，： | 1 |
| 13 | Auditing knowledge management practices: model and application显示文摘 | Meliha Handzic Amila Lagumdzija Amer Celjo | 2008 | Knowledge Management Research & Practice2008，，3： | 1 |
| 14 | Is There Hysteresis in Unemployment in OECD Countries? Evidence From Panel Unit Root Test With Structural Breaks显示文摘 | Meliha Ener Feyza Ariea | 2011 | Chinese Business Review2011，10，4： | 0 |
| 15 | Benefit period using alendronate to increase bone mineral density in women with osteoporosis?显示文摘Background Alendronate, a nitrogen-containing bisphosphonate is a specific inhibitor of bone resorption and now in the forefront of treatment of osteoporosis. In this study, we reported a significant increase in bone mineral density (BMD) of the spine and the hip in postmenopausal women taking alendronate at 10 mg/d for 1, 2 and 3 years. Methods Participants had received daily, oral, 10 mg dose of alendronate for one to three years and placed into one of three groups according to alendronate treatment duration: 41 women received alendronate for 1 year (group Ⅰ), 46 received alendronate for 2 years (group Ⅱ), and 30 received alendronate for 3 years (group Ⅲ). Measurements of bone density had been made by dual energy X-ray absorbtiometry once each year. Results The differences in L2-L4, L2, L4, femoral neck and trochanter BMD values before and after treatment for first group were significantly different. In second group, significant differences between initial and after treatment were found at the other sites except at the Ward’s triangle. In the third group, only a significant increase in the L2-L4, L2, L3, L4, trochanter BMD values between before treatment and at the end of third year was found. Comparisons between groups were performed with Student’s t test. ANOVA was used to test the age, menopause age, menopause duration and initial BMD values between the three groups. Calculated P values of less than 0.05 were considered statistically significant. Conclusions Alendronate had increased BMD significantly at the spine and hip in postmenopausal women over three years. Increases of BMD in third group were significant during the first and second years. However, continued therapy with alendronate had been required to maintain the gain in BMD over the third year. | Ferda Ozdemir Meliha Rodoplu | 2005 | Chinese Medical Journal2005，，5： | 0 |
| 16 | Embracing different languages and local differences:Coconstructive patient simulation strengthens host countries’clinical training in psychiatry显示文摘BACKGROUND Global education in psychiatry is heavily influenced by knowledge from Western,high-income countries,which obscures local voices and expertise.AIM To adapt a human simulation model to psychiatric education in a context that is specific to local languages and cultures.METHODS We conducted an observational study consisting of six human simulation sessions with standardized patients from two host countries,speaking their native languages,and following an adaptation of the co-constructive patient simulation(CCPS)model.As local faculty became increasingly familiar with the CCPS approach,they took on the role of facilitators—in their country’s native language.RESULTS Fifty-three learners participated:19 child and adolescent psychiatry trainees and 3 faculty members in Türkiye(as a group that met online during 3 consecutive months);and 24 trainees and 7 faculty in Israel(divided into 3 groups,in parallel in-person sessions during a single training day).Each of the six cases reflected local realities and clinical challenges,and was associated with specific learning goals identified by each case-writing trainee.CONCLUSION Human simulation has not been fully incorporated into psychiatric education:The creation of immersive clinical experiences and the strengthening of reflective practice are two areas ripe for development.Our adaptations of CCPS can also strengthen local and regional networks and psychiatric communities of practice.Finally,the model can help question and press against hegemonies in psychiatric training that overshadow local expertise. | Şafak ErayÇamlı Büşra Ece Yavuz Meliha Feyza Gök Idil Yazgan Yanki Yazgan Ayelet Brand-Gothelf Doron Gothelf Doron Amsalem Andrés Martin | 2024 | World Journal of Psychiatry2024，14，1： | 0 |
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