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| 1 | Hallmarks in colorectal cancer:Angiogenesis and cancer stem-like cells显示文摘Carcinogenesis is a multistep process that requires the accumulation of various genetic and epigenetic aberrations to drive the progressive malignant transformation of normal human cells.Two major hallmarks of carcinogenesis that have been described are angiogenesis and the stem cell characteristic of limitless replicative potential.These properties have been targeted over the past decade in the development of therapeutic treatments for colorectal cancer(CRC),one of the most commonly diagnosed and lethal cancers worldwide.The treatment of solid tumor cancers such as CRC has been challenging due to the heterogeneity of the tumor itself and the chemoresistance of the malignant cells.Furthermore,the same microenvironment that maintains the pool of intestinal stem cells that contribute to the continuous renewal of the intestinal epithelia also provides the necessary conditions for proliferative growth of cancer stem-like cells.These cancer stem-like cells are responsible for the resistance to therapy and cancer recurrence,though they represent less than 2.5%of the tumor mass.The stromal environment surrounding the tumor cells,referred to as the tumor niche,also supports angiogenesis,which supplies the oxygen and nutrients needed for tumor development.Anti-angiogenic therapy,such as with bevacizumab,a monoclonal antibody against vascular-endothelial growth factor,significantly prolongs the survival of metastatic CRC patients.However,such treatments are not completely curative,and a large proportion of patient tumors retain chemoresistance or show recurrence.This article reviews the current knowledge regarding the molecular phenotype of CRC cancer cells,as well as discusses the mechanisms contributing to their maintenance.Future personalized therapeutic approaches that are based on the interaction of the carcinogenic hallmarks,namely angiogenic and proliferative attributes,could improve survival and decrease adverse effects induced by unnecessary chemotherapy. | Muriel Mathonnet Aurelie Perraud Niki Christou Hussein Akil Carole Melin Serge Battu Marie-Odile Jauberteau Yves Denizot | 2014 | World Journal of Gastroenterology2014，20，15： | 5 |
| 2 | Effect of grape seed proanthocyanidins on colon aberrant crypts and breast tumors in a rat dual-organ tumor model 显示文摘 | Singletary K W Meline B | 2001 | Nutr Cancer2001，39，： | 2 |
| 3 | Effect of Six-Food Elimination Diet on Clinical and Histologic Outcomes in Eosinophilic Esophagitis显示文摘 | Amir F. Kagalwalla Timothy A. Sentongo Sally Ritz Therese Hess Suzanne P. Nelson Karan M. Emerick Hector Melin–Aldana B.U.K. Li | 2006 | Clinical Gastroenterology and Hepatology2006，，： | 2 |
| 4 | Wastewater reuse in Europe显示文摘 | D. Bixio C. Thoeye J. De Koning D. Joksimovic D. Savic T. Wintgens T. Melin | 2006 | Desalination2006，，1： | 2 |
| 5 | Effects of inhaled N-acetylcysteine in combination with terbutaline显示文摘 | Stiksa G Nemcek K Melin S | 1984 | Eur J Respir Dis1984，65，4： | 1 |
| 6 | An improved method for cdgc detection based on interval type-2 fuzzy logic显示文摘 | MELIN P MENDOZA O CASTILLO O | 2010 | Expert Systems with Applications2010，37，12： | 1 |
| 7 | Tonic and phasic descend- ing dopaminergic controls of nociceptive transmission in the me- dullary dorsal horn显示文摘 | Lapirot O Melin C Modolo A | 2011 | Pain2011，152，8： | 1 |
| 8 | Co-cultivation Of antifungal Lactobacillus plantarum MiLAB 393 and Aspergillus nidulans, evaluation of effects on fungal growth and protein expression显示文摘 | STROM K SCHN!3RER J MELIN P | 2005 | FEMS Microbiology Letters2005，246，： | 1 |
| 9 | Transforming biogas into biomethane using membrane technology显示文摘 | Scholz M Melin T Wessling M | 2013 | Renewable & Sustainable Energy Reviews2013，17，： | 1 |
| 10 | Microvascular obstruction and left ventricular remodeling early after acute myocardial infarction显示文摘 | GERBER B L ROCHITTE C E MELIN J A | 2000 | Circulation2000，101，： | 1 |
| 11 | Endocrine disrupter removal from wastewater using membrane bioreactor and nanofiltration technology 显示文摘 | Wintgens T Gallenkemper M Melin T | 2002 | Desalination2002，146，13： | 1 |
| 12 | Behavioural hearing tactics : a controlled trial of a short treatment programme显示文摘 | Andersson G Green M Melin L | 1997 | Behav Res Ther1997，35，： | 1 |
| 13 | Electrocardiographic findings in subarachnoid hemorrhage,a population study显示文摘 | Melin J Fogelholm R | 1983 | Acta Med Scand1983，213，1： | 1 |
| 14 | Intelligent adaptive modelbased control of robotic dynamic systems with a hybrid fuzzy - neural approach显示文摘 | Castillo Oscar Melin Patricia | 2003 | Applied Soft Computing Journal2003，3，4： | 1 |
| 15 | Protective effect of insulin on ischemic renal injury in diabetes mellitus显示文摘 | Melin J Hellberg O Larsson E | 2002 | Kidney Int2002，61，4： | 1 |
| 16 | The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs显示文摘 | Katouli M Melin L Jensen-Waren M | 1999 | Journal of Microbiology1999，87，： | 1 |
| 17 | Effect of grape seed proanthocyanidin on colon aberrant crypts and breast tumora in a ral dual-organ tumor model显示文摘 | Singletary K W Melin B | 2001 | Nature and Caner2001，29，2： | 1 |
| 18 | Membrane bioreac- tor technology for wastewater treatment and reuse 显示文摘 | Melin T Jefferson B Bixio D | 2006 | Desalination2006，187，13： | 1 |
| 19 | The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs显示文摘 | Katouli M Melin L Jensen-Waern M | 1999 | J Appl Microbiol1999，87，： | 1 |
| 20 | Potential use of oxytocin and vasopressin Via antagonists in the treatment of pretenn labour and primary dysmenorrhoea 显示文摘 | Akerlund M Melin P Maggi M | 1995 | Adv Exp Med Biol1995，395，： | 1 |
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