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| 1 | The IKK-related kinases: from innate immunity to oncogenesis显示文摘在过去的四年,天生的有免疫力的反应的地被 kinase ( IKK )联系了 kinases ,坦克有约束力的 Kinase 1 ( TBK1 )和 IKKi 的 IB 的发现高度影响了,它调整干扰素的活动规章的因素( IRF ) -3/IRF-7 和 NF-B 抄写因素。更最近,激活这些 IKK 相当或相同事物的发信号的小径的另外的必要部件被发现了。这些包括 RNA helicases RIGi 和 MDA5,和作为 CARDIF/MAVS/VISA/IPS-1 知道的下游的 mitochondrial 受动器。除了他们在控制天生的有免疫力的反应的必要功能,最近的研究在房间增长和 oncogenesis 加亮这些 kinases 的一个角色。正规 IKK 很好被认出是连接长期的发炎到癌症的一座桥。新调查结果现在建议 IKK 相关的 kinases TBK1 和 IKKi 也参予影响房间转变和肿瘤前进的发信号的小径。这评论将因此由集中于他们的规定和底层特性在细胞的转变和 oncogenesis 总结并且讨论 TBK1 和 IKKi 的角色。 | Jean-Francois Clément | 2008 | Cell Research2008，18，9： | 16 |
| 2 | Transplantation for the treatment of type 1 diabetes显示文摘Transplantation of pancreatic tissue,as either the intact whole pancreas or isolated pancreatic islets has become a clinical option to be considered in the treatment of patients with type 1 insulin-dependant diabetes mellitus. A successful whole pancreas or islet transplant offers the advantages of attaining normal or near normal blood glucose control and normal hemoglobin A1c levels without the risks of severe hypoglycemia associate with intensive insulin therapy. Both forms of transplants are also effective at eliminating the occurrence of significant hypoglycemic events (even with only partial islet function evident). Whereas whole pancreas transplantation has also been shown to be very effective at maintaining a euglycemic state over a sustained period of time,thus providing an opportunity for a recipient to benefit from improvement of their blood glucose control,it is associated with a significant risk of surgical and post-operative complications. Islet transplantation is attractive as a less invasive alternative to whole pancreas transplant and offers the future promise of immunosuppression-free transplantation through pre-transplant culture. Islet transplantation however,may not always achieve the sustained level of tight glucose control necessary for reducing the risk of secondary diabetic complications and exposes the patient to the adverse effects of immunosuppression. Although recent advances have led to an increased rate of obtaining insulin-independence following islet transplantation,further developments are needed to improve the long-term viability and function of the graft to maintain improved glucose control over time. | R Mark Meloche | 2007 | World Journal of Gastroenterology2007，13，47： | 3 |
| 3 | Image restoration显示文摘 | Chan A Meloche J | 1997 | Journal of Statistical Planning and Inference1997，65，： | 2 |
| 4 | The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition 显示文摘 | Meloche S Pouyssegur J | 2007 | Oncogene2007，26，22： | 1 |
| 5 | Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor:the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals显示文摘 | Zhang D Bar-Eli M Meloche S | 2004 | Biol Chem2004，279，19： | 1 |
| 6 | Atypical mitogen- activated protein kinases : structure, regulation and functions 显示文摘 | COULOMBE P MELOCHE S | 2007 | Biochim Biophys Acta2007，1773，8： | 1 |
| 7 | Role of p70 S6 protein kinase in angintens Ⅱ-induced protein synthesis in vascular smooth muscle cells显示文摘 | Giasson E Meloche S | 1995 | J Biol Chem1995，270，10： | 1 |
| 8 | A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes 显示文摘 | Warnock GL Thompson DM Meloche RM | 2008 | Transplantation2008，86，： | 1 |
| 9 | Altered tissue amino acid metabolism in acute T - 2 toxicosis显示文摘 | Meloche J L Smith T K | 1995 | Proceedings of the Society for Experimental Biology and Medicine1995，210，： | 1 |
| 10 | Erk2 Signaling and early embryo stem cell self-renewal显示文摘 | Meloche S Vella F D Voisin L | 2004 | Cell Cycle2004，3，3： | 1 |
| 11 | Different subceUu- lar localization of sulphotransferase 2Blb in human placenta and prostate 显示文摘 | He D Meloche CA Dumas NA | 2004 | Biochem J2004，379，： | 1 |
| 12 | A typical mitogan-activated protein kinases:structure,regulation and functions显示文摘 | Coulombe P Meloche S | 2007 | Biochim Biophys Acta2007，1773，8： | 1 |
| 13 | Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate显示文摘 | He D Meloche CA Dumas NA | 2004 | Biochem J2004，79，： | 1 |
| 14 | Reduced progression of diabetic microvascular complications with islet cell transplantation compared with intensive medical therapy显示文摘 | Thompson DM Meloche M Ao Z | | 0，，03： | 1 |
| 15 | P38 MAP kinase pathway regulates angiotensin Ⅱ-indueed contraetion of rat vascular smooth muscle显示文摘 | Meloche S Landry J Huot J | 2000 | Am J Physiol Heart Circ Physiol2000，279，2： | 1 |
| 16 | From basic research to clinical development of MEK1/2 inhibitors for cancer therapy显示文摘 | Fremin C Meloche S | 2010 | J Hematol Oncol2010，3，2： | 1 |
| 17 | Prospective comparison of early and late experience with laparoscopic adrenalectomy显示文摘 | CHAN J E MENEGHETTI A T MELOCHE R M | 2006 | Am J Surg2006，191，5： | 1 |
| 18 | Differential reg-ulation of p27 (Kipl) expression by mitogenic and hypertrophic fac- tors:Invalvement of transcriptional and posttranscfiptional mecha-nisms显示文摘 | Servant M J Coulombe P Turgeon B Meloche S | 2000 | J Cell Biol2000，148，3： | 1 |
| 19 | p38 MAP kinase pathway regulates angiotensin Ⅱ-induced contraction of rat vascular smooth muscle显示文摘 | Meloche S Landry J Huot J | 2000 | Am J Physiol Heart Circ Physiol2000，279，2： | 1 |
| 20 | Therapeutic potential of mieroRNA modulation in pulmonary arterial hypertension显示文摘 | Meloche J Paulin R Provencher S | | Curr Vasc Pharmacol0，013，： | 1 |
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