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| 1 | Preparation,characterization and biological properties of a novel bone block composed of platelet rich fibrin and a deproteinized bovine bone mineral显示文摘Alveolar bone defects caused by tooth loss often lead to challenges in implant dentistry,with a need for development of optimal bone biomaterials to predictably rebuild these tissues.To address this problem,we fabricated a novel bone block using platelet-rich fibrin(PRF)and Deproteinized Bovine Bone Mineral(DBBM),and characterized their mechanical and biological properties.The bone block was prepared by mixing DBBM,Liquid-PRF,and Solid-PRF fragments in various combinations as follows:(1)BLOCK-1 made with Solid-PRF fragments+DBBM,(2)BLOCK-2 made with Liquid-PRF+DBBM,(3)BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+DBBM.The time for solidification and the degradation properties were subsequently recorded.Scanning electron microscopy(SEM)and tensile tests were carried out to investigate the microstructure and mechanical properties of each block.The bioactivity of the three groups towards osteoblast differentiation was also evaluated by culturing cells with the conditioned medium from each of the three groups including cell proliferation assay,cell migration assay,alkaline phosphatase(ALP)staining,and alizarin red staining(ARS),as well as by real-time PCR for genes encoding runt-related transcription factor 2(RUNX2),ALP,collagen type I alphal(COLIv41)and osteocalcin(OCN).BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+DBBM had by far the fastest solidification period(over a 10-fold increase)as well as the most resistance to degradation.SEM and tensile tests also revealed that the mechanical properties of BLOCK-3 were superior in strength when compared to all other groups and further induced the highest osteoblast migration and osteogenic differentiation confirmed by ALP,ARS and real-time PCR.PRF bone blocks made through the combination of Solid-PRF fragments+Liquid-PRF+DBBM had the greatest mechanical and biological properties when compared to either used alone.Future clinical studies are warranted to further support the clinical application of PRF bone blocks in bone regeneration procedures. | Mengge Feng Yulan Wang Yan Wei Xiaoxin Zhang Leyi Xiao Zijjian Gong Masako Fujioka-Kobayashi Anton Sculean Richard J Miron Scott Froum Yufeng Zhang | 2022 | Fundamental Research2022，2，2： | 3 |
| 2 | Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma显示文摘Glioblastoma(GBM)is the most common and aggressive malignant brain tumor in adults and is poorly controlled.Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression,and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for GBM treatment.Therefore,this study developed a novel and selective inhibitor of CSFIR and VEGFR,SYHA1813,possessing potent antitumor activity against GBM.SYHA1813 inhibited VEGFR and CSFIR kinase activities with high potency and selectivity and thus blocked the cell viability of HUVECs and macrophages and exhibited anti-angiogenetic effects both in vitro and in vivo.SYHA1813 also displayed potent in vivo antitumor activity against GBM in immune-competent and immune-deficient mouse models,including temozolomide(TMZ)insensitive tumors.Notably,SYHA1813 could penetrate the blood-brain barrier(BBB)and prolong the survival time of mice bearing intracranial GBM xenografts.Moreover,SYHA1813 treatment resulted in a synergistic antitumor efficacy in combination with the PD-1 antibody.As a clinical proof of concept,SYHA1813 achieved confirmed responses in patients with recurrent GBM in an ongoing first-in-human phase I trial.The data of this study support the rationale for an ongoing phase I clinical study(ChiCTR2100045380). | Yingqiang Liu Zhengsheng Zhan Zhuang Kang Mengyuan Li Yongcong Lv Shenglan Li Linjiang Tong Fang Feng Yan Li Mengge Zhang Yaping Xue Yi Chen Tao Zhang Peiran Song Yi Su Yanyan Shen Yiming Sun Xinying Yang Yi Chen Shanyan Yao Hanyu Yang Caixia Wang Meiyu Geng Wenbin Li Wenhu Duan Hua Xie Jian Ding | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 3 | A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy显示文摘Oncogenes are critical factors in tumorigenesis of diverse cancer types and play essential roles in tumor immune escape.Mutations in Kirsten rat sarcoma viral oncogene homolog(KRAS)and epidermal growth factor receptor(EGFR)are among the most frequent gain-of-function alterations[1].After many years of in-depth research,inhibitors targeting EGFR or KRAS mutations have been successfully developed,however,their clinical benefit is relatively limited,and they will inevitably encounter the challenge of drug resistance.The emergence of resistance is attributed to secondary mutations in driver genes and other complicated factors. | Yingqiang Liu Linjiang Tong Mengge Zhang Qi Zhang Qiupei Liu Fang Feng Yan Li Mengzhen Lai Haotian Tang Yi Chen Meiyu Geng Wenhu Duan Jian Ding Hua Xie | 2024 | Cancer Communications2024，44，3： | 0 |
| 4 | Molecular ferroelectric/semiconductor interfacial memristors for artificial synapses显示文摘With the burgeoning developments in artificial intelligence,hardware implementation of artificial neural network is also gaining pace.In this pursuit,ferroelectric devices(i.e.,tunneling junctions and transistors)with voltage thresholds were recently proposed as suitable candidates.However,their development is hindered by the inherent integration issues of inorganic ferroelectrics,as well as poor properties of conventional organic ferroelectrics.In contrast to the conventional ferroelectric synapses,here we demonstrated a two-terminal ferroelectric synaptic device using a molecular ferroelectric(MF)/semiconductor interface.The interfacial resistance can be tuned via the polarization-controlled blocking effect of the semiconductor,owing to the high ferroelectricity and field amplification effect of the MF.Typical synaptic features including spike timing-dependent plasticity are substantiated.The introduction of the semiconductor also enables the attributes of optoelectronic synapse and in-sensor computing with high image recognition accuracies.Such interfaces may pave the way for the hardware implementation of multifunctional neuromorphic devices. | Yichen Cai Jialong Zhang Mengge Yan Yizhou Jiang Husnain Jawad Bobo Tian Wenchong Wang Yiqiang Zhan Yajie Qin Shisheng Xiong Chunxiao Cong Zhi-Jun Qiu Chungang Duan Ran Liu Laigui Hu | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 5 | Associative learning of a three-terminal memristor network for digits recognition显示文摘Imitating the associative intelligence of the biological brain is attractive but is poorly achieved in hardware because the complex tunable connection in neural networks is difficult to reproduce. We develop a circuit composed of a three-terminal memristor network to reproduce the biological conditioning process artificially. The synaptic weight between co-firing neurons is strengthened simultaneously by generating a feedback signal from the integrate-and-fire neuron to the gate of the synaptic memristor. The network allows the multi-associative capacity of recalling more than one digit in one circuit. Both single and multi-associative learning for recalling digital images are achieved. Furthermore, all 10 digital images from “0” to “9” are successfully recalled in an associative network with such paralleling circuits. Assisted by this associative layer, a typical classification network effectively improves the recognition rate for fragmentary digital images.Our work sheds light on brain-inspired artificial associative memory and provides a strategy for applications,such as object recognition with partial features and similar scenes. | Yiming REN Bobo TIAN Mengge YAN Guangdi FENG Bin GAO Fangyu YUE Hui PENG Xiaodong TANG Qiuxiang ZHU Junhao CHU Chungang DUAN | 2023 | Science China(Information Sciences)2023，66，2： | 0 |
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