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| 1 | Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice显示文摘Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however, the underlying molecular mechanism remains largely unknown. MSX1 is an anteriorly expressed transcription repressor required for palate development. Here, we investigate the role of Msx1 in regional patterning of the secondary palate. The Wnt1-Cre-mediated expression of Msx1(Rosa Msx1^(Wnt1-Cre))throughout the palatal mesenchyme leads to cleft palate in mice, associated with aberrant cell proliferation and cell death. Osteogenic patterning of the hard palate in Rosa Msx1^(Wnt1-Cre)mice is severely impaired, as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7. Overexpression and knockout of Msx1 in mice show that the transcription repressor promotes the expression of the anterior palate-specific Alx1 but represses the expression of the medialposterior palate genes Barx1, Meox2, and Tbx22. Furthermore, Tbx22 constitutes a direct Msx1 target gene in the secondary palate, suggesting that Msx1 can directly repress the expression of medial-posterior specific genes. Finally, we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development. Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate. | Shicheng Zhu Hanjing Song Liangjun Zhong Suman Huo Yukun Fang Wanxin Zhao Xueqin Yang Zhong-Min Dai Rui He Mengsheng Qiu Zunyi Zhang Xiao-Jing Zhu | 2022 | Journal of Genetics and Genomics2022，49，1： | 2 |
| 2 | Dose-dependent regulation of oligodendrocyte specification by β-catenin signaling显示文摘Dear Editor,Although various components of the Wnt/β-catenin pathway have been investigated,there are conflicting reports on the roles of Wnt/β-catenin signaling in oligodendrogenesis and differentiation.For instance,theΔExon3 mutation ofβ-catenin[1-4],which stabilizesβ-catenin by deletion of the phosphorylation site for the destruction complex,signifi cantly inhibits the differentiation of oligodendrocytes, | Shuhui Sun Wei Guo Zunyi Zhang Mengsheng Qiu Zhong-Min Dai | 2015 | Neuroscience Bulletin2015，31，2： | 1 |
| 3 | TAPP1 inhibits the differentiation of oligodendrocyte precursor cells via suppressing the Mek/Erk pathway显示文摘Oligodendrocytes(OLs) are glial cells that form myelin sheaths around axons in the central nervous system(CNS).Loss of the myelin sheath in demyelinating and neurodegenerative diseases can lead to severe impairment of movement.Understanding the extracellular signals and intracellular factors that regulate OL differentiation and myelination during development can help to develop novel strategies for enhancing myelin repair in neurological disorders.Here,we report that TAPP1 was selectively expressed in differentiating OL precursor cells(OPCs).TAPP1 knockdown promoted OL differentiation and myelin gene expression in culture.Conversely,over-expression of TAPP1 in immature OPCs suppressed their differentiation.Moreover,TAPP1 inhibition in OPCs altered the expression of Erk1/2 but not AKT.Taken together,our results identify TAPP1 as an important negative regulator of OPC differentiation through the Mek/Erk signaling pathway. | Yidan Chen Ruyi Mei Peng Teng Aifen Yang Xuemei Hu Zunyi Zhang Mengsheng Qiu Xiaofeng Zhao | 2015 | Neuroscience Bulletin2015，31，5： | 1 |
| 4 | Research on Soil Conservation and Improvement Technology in Zhaoyang District显示文摘The environment of tobacco-growing soil directly affects the yield and quality of tobacco leaves.In order to solve problems of tobacco-growing soil degradation,low organic matter content and unbalanced soil nutrient supply and promote sustainable and healthy development of tobacco production,this paper comprehensively discussed conservation and improvement techniques of tobacco-growing soil based on existing problems in Zhaoyang District,aiming to provide reference for tobacco-growing soil conservation. | Jing YANG Shifu ZHONG Liting FANG Wei YAN Shixian PU Dianli MA Wenkai XIA Haohan GONG Mengsheng ZHANG Yeming FU Xia NI | 2024 | Agricultural Biotechnology2024，13，1： | 0 |
| 5 | Effects of Microbial Fertilizers in Improving Acidic Tobacco-planting Soil and Tobacco Leaf Quality显示文摘[Objectives]This study was conducted to improve acidic soil and enhance the quality of tobacco leaves.[Methods]The effects of different microbial fertilizers on improving acidic tobacco-planting soil and tobacco leaf quality were investigated through plot experiments.[Results]The application of microbial fertilizers could improve the pH value of acidic soil,and composite microbial agent A showed the best application effect.The application of bio-organic fertilizer was beneficial to improving the contents of available phosphorus and available boron in acidic soil.The application of composite microbial agent A was beneficial to improving the contents of available phosphorus and available potassium in acidic soil,and could promote the growth of tobacco plants and improve the economic traits of flue-cured tobacco and the coordination of chemical components in tobacco leaves.The application of composite microbial agent B led to a downward trend in the content of available boron in acidic soil.The application of composite microbial agent B could promote the absorption of nutrients by tobacco plants,and improve their disease resistance and the quality of tobacco leaves.Due to the differences in functional microorganisms contained,the application effects of different microbial fertilizers in improving acidic tobacco-planting soil and improving tobacco leaf quality varied.Overall,the application of microbial fertilizers could increase soil pH,activate soil nutrients,promote tobacco growth,enhance disease resistance,increase tobacco output value,and improve tobacco quality.Microbial fertilizers have good application prospects in improving acidic soil and improving tobacco quality.[Conclusions]The application of microbial fertilizers to improve acidic tobacco-planting soil can ensure the normal growth and development of tobacco plants and the improvement of tobacco leaf quality,achieving high-quality and sustainable development of Zhaotong tobacco. | Xia NI Shungang SHEN Xianyi ZENG Dewen LI Yeming FU Min CHEN Chaokai YU Libing QI Ying-guo RUAN Changchong ZI Haohan GONG Guangjun HU Mengsheng ZHANG Xu ZHANG Shu PENG Hongbing LI | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
| 6 | Effects of Different Chemical Fertilizer Reduction Techniques on Flue-cured Tobacco Production显示文摘[Objectives]This study was conducted to find out the most suitable special formula fertilizer for flue-cured tobacco production in tobacco-growing areas of Zhaotong City,so as to provide a basis for scientific fertilization and reduced application of inorganic fertilizers with improved efficiency in tobacco production in Zhaotong City.[Methods]Different formulas of special base fertilizer and special topdressing for tobacco were designed by optimizing and adjusting the application amounts and proportions of nitrogen,phosphorus,potassium and medium trace elements in fertilizer formulas,and the formulas of special base fertilizer and special topdressing for flue-cured tobacco production were selected through a field plot experiment.[Results]The combination of special base fertilizer and special topdressing was conducive to the early growth and rapid growth of tobacco plants under the condition of reduced fertilizer application,and the treatment using organic-inorganic compound fertilizer as the special base fertilizer was the most obvious,with an average growth period of two days increased.Compared with conventional fertilization,the yield,output value,average price,proportion of superior tobacco and proportion of medium and superior tobacco increased in the organic-inorganic compound fertilizer treatment,with the yield increasing by 5.96%,the output value increasing by 17.08%,the average price increasing by 10.49%,the proportion of superior tobacco increasing by 4.63%,and the proportion of medium and superior tobacco increasing by 2.44%.It was concluded from indexes including growth period,agronomic traits,disease incidence and economic traits,the fertilization mode of organic-inorganic compound fertilizer with the addition of trace elements(boron,magnesium and zinc)applied as the base fertilizer and nitrogen and potassium topdressing was most efficient and economic.[Conclusions]This study provides a basis for scientific fertilization and reduced application of inorganic fertilizers with improved efficiency in tobacco production in Zhaotong City. | Longfeng GUI Lei XIA Jing YANG Wei YAN Yu ZHOU Yuzhong ZHOU Haohan GONG Mengsheng ZHANG Yeming FU Xianyi ZENG Xia NI | 2023 | Agricultural Biotechnology2023，12，6： | 0 |
| 7 | Oligodendrocytes in central nervous system diseases:the effect of cytokine regulation显示文摘Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines are involved in nearly every aspect of cellular functions such as migration, survival, proliferation, and differentiation. Oligodendrocytes are the myelin-forming cells in the central nervous system and play critical roles in the conduction of action potentials, supply of metabolic components for axons, and other functions. Emerging evidence suggests that both oligodendrocytes and oligodendrocyte precursor cells are vulnerable to cytokines released under pathological conditions. This review mainly summarizes the effects of cytokines on oligodendrocyte lineage cells in central nervous system diseases. A comprehensive understanding of the effects of cytokines on oligodendrocyte lineage cells contributes to our understanding of central nervous system diseases and offers insights into treatment strategies. | Chengfu Zhang Mengsheng Qiu Hui Fu | 2024 | Neural Regeneration Research2024，19，10： | 0 |
| 8 | Nuclear Factor I/A Controls A-fiber Nociceptor Development显示文摘Noxious mechanical information is transmitted through molecularly distinct nociceptors,with pinprickevoked sharp sensitivity via A-fiber nociceptors marked by developmental expression of the neuropeptide Y receptor 2(Npy2 r)and von Frey filament-evoked punctate pressure information via unmyelinated C fiber nociceptors marked by MrgprD.However,the molecular programs controlling their development are only beginning to be understood.Here we demonstrate that Npy2 r-expressing sensory neurons are in fact divided into two groups,based on transient or persistent Npy2 r expression.Npy2 r-transient neurons are myelinated,likely including A-fiber nociceptors,whereas Npy2 r-persistent ones belong to unmyelinated pruriceptors that co-express Nppb.We then showed that the transcription factors NFIA and Runx1 are necessary for the development of Npy2 r-transient A-fiber nociceptors and MrgprD^+C-fiber nociceptors,respectively.Behaviorally,mice with conditional knockout of Nfia,but not Runx1 showed a marked attenuation of pinprick-evoked nocifensive responses.Our studies therefore identify a transcription factor controlling the development of myelinated nociceptors. | Lu Qi Guangjuan Yin Yongchao Zhang Yeqi Tao Xiaohua Wu Richard M.Gronostajski Mengsheng Qiu Yang Liu | 2020 | Neuroscience Bulletin2020，36，7： | 0 |
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