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| 1 | Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition显示文摘The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis,homeostasis and function.Vascular endothelial growth factor-a(VEGFA)has been commonly recognized as a pro-angiogenic factor in vertebrate developmental,physiological and pathological conditions for decades.Here we report a novel finding that genetic ablation of CDP-diacylglycerol synthetase-2(CDS2),a metabolic enzyme that controls phosphoinositide recycling,switches the output of VEGFA signaling from promoting angiogenesis to unexpectedly inducing vessel regression.Live imaging analysis uncovered the presence of reverse migration of the angiogenic endothelium in cds2 mutant zebrafish upon VEGFA stimulation,and endothelium regression also occurred in postnatal retina and implanted tumor models in mice.In tumor models,CDS2 deficiency enhanced the level of tumorsecreted VEGFA,which in-turn trapped tumors into a VEGFA-induced vessel regression situation,leading to suppression of tumor growth.Mechanistically,VEGFA stimulation reduced phosphatidylinositol(4,5)-bisphosphate(PIP2)availability in the absence of CDS2-controlled-phosphoinositide metabolism,subsequently causing phosphatidylinositol(3,4,5)-triphosphate(PIP3)deficiency and F0X01 activation to trigger regression of CDS2-null endothelium.Thus,our data indicate that the effect of VEGFA on vasculature is context-dependent and can be converted from angiogenesis to vascular regression. | Wencao Zhao Le Cao Hanru Ying Wenjuan Zhang Dantong Li Xiaolong Ziiu Wenzhi Xue Shuang Wu Mengye Cao Cong Fu Haonan Qi Yimei Hao Yun-Chi Tang Jun Qin Tao PZhong Xiaoxi Lin Luyang Yu Xuri Li Lin Li Dianqing Wu Weijun Pan | 2019 | Cell Research2019，29，11： | 9 |
| 2 | Co-catalyst-free large ZnO single crystal for high-efficiency piezocatalytic hydrogen evolution from pure water显示文摘Piezocatalytic materials have been widely used for catalytic hydrogen evolution and purification of organic contaminants.However,most studies focus on nano-size and/or polycrystalline catalysts,suffering from aggregation and neutralization of internal piezoelectric field caused by polydomains.Here we report a single crystal ZnO of large size and few bulk defects crafted by a hydrothermal method for piezocatalytic hydrogen generation from pure water.It is noteworthy that single-side surface areas of both original as-prepared ZnO and Ga-doped ZnO bulk crystals are larger than 30 cm^(2).The high quality of ZnO and Ga-doped ZnO bulks are further uncovered by high-resolution transmission electron microscope(HRTEM),photoluminescence(PL)and X-ray diffraction(XRD).Remarkably,an outstanding hydrogen production rate of co-catalyst-free Ga-doped ZnO bulk crystal(i.e.,a maximum rate of 5915μmol h^(-1) m^(-2))is observed in pure water triggered by ultrasound in dark,which is over 100 times higher than that of its powder counterpart(i.e.,52.54μmol h^(-1) m^(-2)).The piezocatalytic performance of ZnO bulk crystal is systematically studied in terms of varied exposed crystal facet,thickness and conductivity.Different piezocatalytic performances are attributed to magnitude and distribution of piezoelectric potential,revealed by the finite element method(FEM)simulation.The density functional theory(DFT)calculations are employed to investigate the piezocatalytic hydrogen evolution process,indicating a strong H_(2)O adsorption and a low energy barrier for both H_(2)O dissociation and H2 generation on the stressed Znterminated(0001)ZnO surface. | Biao Wang Qian Zhang Jiaqing He Feng Huang Caifu Li Mengye Wang | 2022 | Journal of Energy Chemistry2022，31，2： | 4 |
| 3 | Iron oxide nanoparticles promote vascular endothelial cells survival from oxidative stress by enhancement of autophagy显示文摘Dextran-coated superparamagnetic iron oxide nanoparticles(Dex-SPIONs)are excellent magnetic resonance imaging contrast agents for disease diagnosis and therapy.They can be delivered to target tissues mainly though vascular endothelium cells,which are major targets of oxidative stress.In cardiovascular cells,autophagy serves primarily on a pro-survival approach that protects the cells from oxidative stress even some autophagy inducers have been developed for adjuvant therapy of cardiovascular disorders.Our study demonstrated that the nanoparticles could be taken up by human umbilical vein endothelial cells(HUVECs)without causing obvious cytotoxicity but triggering autophagy.Furthermore,our results revealed that Dex-SPIONs could enhance HUVECs survival and reverse the reduction of nitric oxide secretion under the condition of H2O2 damage.However,these effects could be diminished by the autophagy inhibitor.In particular,we discovered that Dex-SPIONs evoked autophagy in HUVECs by reducing the phosphorylation of PRAS40,an upstream regulator of autophagy initiation.These results suggested that Dex-SPIONs functions as an autophagic-related antioxidant in HUVECs which may be utilized as an adjuvant therapy to cardiovascular disease associated with oxidative stress. | Jimei Duan Jiuju Du Rongrong Jin Wencheng Zhu Li Liu Li Yang Mengye Li Qiyong Gong Bin Song James MAnderson and Hua Ai | 2019 | Regenerative Biomaterials2019，6，4： | 2 |
| 4 | Dual regulation of osteoclastogenesis and osteogenesis for osteoporosis therapy by iron oxide hydroxyapatite core/shell nanocomposites显示文摘Osteoporosis is a skeletal disorder resulted in significant structural and functional changes,arousing a wide concern for the high prevalence and cost.Imbalance between osteoclastogenesis and osteogenesis have been verified as a main pathology etiology and considered an efficient therapy target in both clinical and pre-clinical studies.In recent years,inorganic nanomaterials have shown provable activities on osteoclastogenesis inhibition and osteogenesis promotion,respectively.Hence,in this study,a class of hydroxyapatite coated superparamagnetic iron oxide nanoparticles(SPIO@HA)were developed with a coreshell structure for targeting both osteoclastogenesis and osteogenesis.The optimal ratio of SPIO@15HA(Fe/Ca¼1:15,mol/mol)was screened to obtain dual function for inducing both bone formation and preventing bone resorption.The obtained nanocomposites significantly prevented the bone loss of ovariectomized(OVX)mice and increased bone mineral density(BMD)by 9.4%,exhibiting high bone accumulation in magnetic resonance imaging evaluation and reasonable biosafety profile.The mechanism study revealed that SPIO@15HA can suppress bone marrow monocyte derived osteoclast differentiation through TRAF6p62CYLD signaling complex regulation.Meanwhile,it could activate MSC osteogenic differentiation by TGF-b,PI3K-AKT and calcium signaling pathway regulation.Moreover,incubation of SPIO@15HA with MSC resulted in several cytokines overexpression such as osteoprotegerin(OPG),CSF2,CCL2 etc.,which are responsible for maintaining the bone remodeling balance.The dual function of as-prepared SPIO@15HA may find a new way for designing of inorganic components containing core/shell nanomaterials for osteoporosis treatment. | Mengye Li Shengxiang Fu Zhongyuan Cai Danyang Li Li Liu Di Deng Rongrong Jin Hua Ai | 2021 | Regenerative Biomaterials2021，8，5： | 1 |
| 5 | A multi-terminal ion-controlled transistor with multifunctionality and wide temporal dynamics for reservoir computing显示文摘Reservoir computing(RC)is an energy-efficient computational framework with low training cost and high efficiency in processing spatiotemporal information.The state-of-the-art fully memristor-based hardware RC system suffers from bottlenecks in the computation efficiencies and accuracy due to the limited temporal tunability in the volatile memristor for the reservoir layer and the nonlinearity in the nonvolatile memristor for the readout layer.Additionally,integrating different types of memristors brings fabrication and integration complexities.To overcome the challenges,a multifunctional multi-terminal electrolyte-gated transistor(MTEGT)that combines both electrostatic and electrochemical doping mechanisms is proposed in this work,integrating both widely tunable volatile dynamics with high temporal tunable range of 10^(2) and nonvolatile memory properties with high long-term potentiation/long-term depression(LTP/LTD)linearity into a single device.An ion-controlled physical RC system fully implemented with only one type of MTEGT is constructed for image recognition using the volatile dynamics for the reservoir and nonvolatility for the readout layer.Moreover,an ultralow normalized mean square error of 0.002 is achieved in a time series prediction task.It is believed that the MTEGT would underlie next-generation neuromorphic computing systems with low hardware costs and high computational performance. | Kekang Liu Jie Li Fangzhou Li Yiyuan Lin Hongrui Liu Linzi Liang Zhiyuan Luo Wei Liu Mengye Wang Feichi Zhou Yanghui Liu | 2024 | Nano Research2024，17，5： | 0 |
| 6 | Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral显示文摘The thalamocortical(TC)circuit is closely asso-ciated with pain processing.The hyperpolarization-activated cyclic nucleotide-gated(HCN)2 channel is predominantly expressed in the ventral posterolateral thalamus(VPL)that has been shown to mediate neuropathic pain.However,the role of VPL HCN2 in modulating TC circuit activity is largely unknown.Here,by using optogenetics,neuronal trac-ing,electrophysiological recordings,and virus knockdown strategies,we showed that the activation of VPL TC neurons potentiates excitatory synaptic transmission to the hindlimb region of the primary somatosensory cortex(S1HL)as well as mechanical hypersensitivity following spared nerve injury(SNI)-induced neuropathic pain in mice.Either pharmaco-logical blockade or virus knockdown of HCN2(shRNA-Hcn2)in the VPL was sufficient to alleviate SNI-induced hyperalgesia.Moreover,shRNA-Hcn2 decreased the excitability of TC neurons and synaptic transmission of the VPL-S1HL circuit.Together,our studies provide a novel mechanism by which HCN2 enhances the excitability of the TC circuit to facilitate neuropathic pain. | Yi Yan Mengye Zhu Xuezhong Cao Gang Xu Wei Shen Fan Li Jinjin Zhang Lingyun Luo Xuexue Zhang Daying Zhang Tao Liu | 2023 | Neuroscience Bulletin2023，39，5： | 0 |
| 7 | Robust route to H_(2)O_(2)and H_(2)via intermediate water splitting enabled by capitalizing on minimum vanadium-doped piezocatalysts显示文摘H_(2)O_(2)is an environmentally friendly chemical for a wide range of water treatments.The industrial production of H_(2)O_(2)is an anthraquinone oxidation process,which,however,consumes extensive energy and produces pollution.Here we report a green and sustainable piezocatalytic intermediate water splitting process to simultaneously obtain H_(2)O_(2)and H_(2)using single crystal vanadium(V)-doped NaNbO_(3)(V-NaNbO_(3))nanocubes as catalysts.The introduction of V improves the specific surface area and active sites of NaNbO_(3).Notably,V-NaNbO_(3)piezocatalysts of 10 mg exhibit 3.1-fold higher piezocatalytic efficiency than the same catalysts of 50 mg,as more piezocatalysts lead to higher probability of aggregation.The aggregation causes reducing active sites and decreased built-in electric field due to the neutralization between different nano-catalysts.Remarkably,piezocatalytic H_(2)O_(2)and H_(2)production rates of V-NaNbO_(3)(10 mol%)nanocubes(102.6 and 346.2μmol·g^(−1)·h^(−1),respectively)are increased by 2.2 and 4.6 times compared to the as-prepared pristine NaNbO_(3)counterparts,respectively.This improved catalytic efficiency is attributed to the promoted piezo-response and more active sites of NaNbO_(3)catalysts after V doping,as uncovered by piezoresponse force microscopy(PFM)and density functional theory(DFT)simulation.More importantly,our DFT results illustrate that inducing V could reduce the dynamic barrier of water dissociation over NaNbO_(3),thus enhancing the yield of H_(2)O_(2)and H_(2).This facile yet robust piezocatalytic route using minimal amounts of catalysts to obtain H_(2)O_(2)and H_(2)may stand out as a promising candidate for environmental applications and water splitting. | Yuekun Li Li Li Fangyan Liu Biao Wang Feng Gao Chuan Liu Jingyun Fang Feng Huang Zhang Lin Mengye Wang | 2022 | Nano Research2022，15，9： | 0 |
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