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| 1 | Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells,BEAS-2B显示文摘 | Veljkovic E Jiricny J Menigatti M | | 0，，： | 1 |
| 2 | Defective DNA mismatch repair determines a characteristic transcriptional profile in proximal colon cancers 显示文摘 | Massimiliano di Pietro Jacob Sabates Bellver Mirco Menigatti | 2005 | Gastroenterology2005，129，3： | 1 |
| 3 | Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid)显示文摘 | Elisa Cattaneo Endre Laczko Federico Buffoli Fausto Zorzi Maria Antonia Bianco Mirco Menigatti Zdena Bartosova Ritva Haider Birgit Helmchen Jacob Sabates‐Bellver Amit Tiwari Josef Jiricny Giancarlo Marra | 2011 | EMBO Mol Med2011，，6： | 1 |
| 4 | Microsatellite instability and mismatch-repair protein expression in hereditary and sporadic colorectal carcinogenesis 显示文摘 | Borhgi F Menigatti M Benatti P | 2001 | Cancer Res2001，61，3： | 1 |
| 5 | A compre- hensive look at transcription factor gene expression changes in col- orectal adenomas显示文摘 | Vonlanthen J Okoniewski MJ Menigatti M | 2014 | BMC cancer2014，14，： | 1 |
| 6 | Normal colorectal mucosa exhibits sex-and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT prornoters显示文摘 | MENIGATTI M TRUNINGER K GEBBERS J O | 2009 | Oneogene2009，28，6： | 1 |
| 7 | Microsatellite instability and mismatch repair protein expression and sporadic colorectal carcinogenesis显示文摘 | Borghi F Menigatti M Benatti P | 2001 | Cancer Res2001，61，3： | 1 |
| 8 | A comprehensive look at transcxiption faclor gene expression changes in coloreclal adenomas 显示文摘 | Vonlanthen J Okoniewski M J Menigatti M | 2014 | BMC Cancer2014，14，： | 1 |
| 9 | The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis 显示文摘 | Menigatti M Cattaneo E Sabates-Bellver J | 2009 | Mol Cancer2009，8，： | 1 |
| 10 | Pinl interacts with C-myb in a phosphorylation-dependent manner and regu- lates its transactivation activity显示文摘 | Pani E Menigatti M Schubert S | 2008 | Biochim Biophys Acta2008，1783，6： | 1 |
| 11 | Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B显示文摘 | Veljkovic E Jiricny J Menigatti M | 2011 | Toxicol In Vitro2011，25，2： | 1 |
| 12 | Methylation pattern of different regions of the MLH1 promoter and silencing of gene expression in hereditary and sporadic colorectal cancer显示文摘 | Menigatti M Di Gregorio C Borghi F | 2001 | Genes Chromosomes Cancer2001，31，4： | 1 |
| 13 | Defective DNA mismatch repair determines a characteristic transcriptional profile in proximal colon cancers 显示文摘 | di Pietro M Sabates Bellver J Menigatti M | 2005 | Gastroenterology2005，129，3： | 1 |
| 14 | Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters 显示文摘 | Menigatti M Truninger K Gebbers JO | 2009 | Oncogene2009，28，6： | 1 |
| 15 | A comprehen-sive look at transcription factor gene expression changes in color-eetal adenomas显示文摘 | Vonlanthen J Okoniewski MJ Menigatti M | 2014 | BMC Cancer2014，14，： | 1 |
| 16 | Methylation pattern of different regions of the MLH1 promoter and silencing of gene ex pression in hereditary and sporadic colorectal cancer显示文摘 | Menigatti M Di Gregorio C Borghi F | 2001 | Genes Chromosomes Cancer2001，31，4： | 1 |
| 17 | Epigenetic silencing of monoallelically methylated miRNA loci in precancerous colorectal lesions显示文摘 | Menigatti M Staiano T Manser CN | 2013 | Oncogenesis2013，2，： | 1 |
| 18 | 缺损DNA错配修复决定一个近侧结肠癌特异的转录模式显示文摘Background & Aims: Colon cancers with defective DNA mismatch repair (MMR) have peculiar molecular, pathologic, and clinical features, including high-level microsatellite instability, conspicuous lymphocytic infiltration, preferential location in the proximal colon, and better prognosis. Our aim was to characterize the transcriptional profile of this colon cancer subset. Methods: An oligonucleotide microarray containing 12,625 probes was used to evaluate gene expression in 25 proximal colon cancers, 10 samples of normal colon mucosa, and 14 colon cancer cell lines. Transcriptional profiles of MMR-deficient cancers and cell lines were compared with those of their MMR-proficient counterparts. Results: Unsupervised anal-ysis of microarray data showed that MMR status exerts a predominant influence on the gene expression profile of proximal colon cancers. Hierarchical clustering divided the cancers into 2 groups corresponding almost perfectly with their MMR status. Supervised analysis identified numerous gene expression changes that represent a genetic signature of MMR-deficient colon cancers. Changes in genes involved in apoptosis and the immune response were consistent with the better prognosis of MMR-deficient cancers. In MMR-deficient cancers and cell lines, 4-1BBL, a crucial gene in the anti-tumor immune response, was, respectively, 2.4 and 6.0 times more expressed than in their MMR-proficient counterparts. This difference was con- firmed by quantitative reverse-transcription polymerase chain reaction and flow cytometric assessment of 4-1BBL protein expression in colon cancer cell lines. Our analysis also showed novel possible gene targets of microsatellite instability. Conclusions: MMR inactivation produces distinct changes in the cellular messenger RNA pool, which is consistent with a unique tumorigenesis pathway. | Di Pietro M. Bellver J.S. Menigatti M. G. Marra 陈云茹 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，2： | 0 |
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