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| 1 | Bone mineral density and disorders of mineral metabolism in chronic liver disease显示文摘AIM:To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis.METHODS:The study was performed on 72 Indian patients with cirrhosis(63 male, 9 female;aged < 50 years).Etiology of cirrhosis was alcoholism(n = 37), hepatitis B(n = 25) and hepatitis C(n = 10).Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C.Secondary causes for metabolic bone disease and osteoporosis were ruled out.Sunlight exposure, physical activity and dietary constituents were calculated.Complete metabolic profiles were derived, and bone mineral density(BMD) was measured using dual energy X ray absorptiometry.Low BMD was defined as a Z score below-2.RESULTS:Low BMD was found in 68% of patients.Lumbar spine was the most frequently and severely affected site.Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass.Calcium intake was adequate, with unfavorable calcium:protein ratio and calcium:phosphorus ratio.Vitamin D deficiency was highly prevalent(92%).There was a high incidence of hypogonadism(41%).Serum estradiol level was elevated significantly in patients with normal BMD.Insulin-like growth factor(IGF) 1 and IGF binding protein 3 levels were below the age-related normal range in both groups.IGF-1 was signiflcantly lower in patients with low BMD.Serum osteocalcin level was low(68%) and urinary deoxypyridinoline to creatinine ratio was high(79%), which demonstrated low bone formation with high resorption.CONCLUSION:Patients with cirrhosis have low BMD.Contributory factors are reduced physical activity, low lean body mass, vitamin D def iciency and hypogonadism and low IGF-1 level. | Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana Karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah | 2009 | World Journal of Gastroenterology2009，15，28： | 15 |
| 2 | DDT residues in the River Jamuna in Delhi, India 显示文摘 | Agarwal H C Mittal P K Menon K B | 1986 | Wat Air Soil Pollut1986，28，： | 2 |
| 3 | Optimal trajectory syn-thesis for terrain-following flight显示文摘 | Menon P K A Kim E Cheng V H L | 1991 | Journal of Guidance Control and Dynamics1991，14，4： | 1 |
| 4 | Control of low velocity friction and gear backlash in a machine tool feed drive system显示文摘 | Menon K Krishnamurthy K | 1999 | Mechatronics1999，，9： | 1 |
| 5 | The BuddChiari syndrome显示文摘 | Menon K V Shah V Kamath P S | 2004 | N Engl J Med2004，350，6： | 1 |
| 6 | (31 Integrins expression in adult rat ventricular myocytes and itsrole in the regulation of beta-adrenergic receptor-stimulated ap-optosis显示文摘 | Communal C Singh M Menon B Xie Z Colucci W S Singh K | 2003 | J Cell Biochem2003，89，： | 1 |
| 7 | Redefining the R1 resec- tion in pancreatic cancer显示文摘 | Verbeke C Leitch D Menon K | 2006 | Br J Surg2006，93，10： | 1 |
| 8 | Integrated Guidance and Control of Moving-mass Actuated Kinetic Warheads显示文摘 | Menon K P Sweriduk D G Ohlmeyer E J Malyevac S D | 2004 | Journal of Guidance Control and Dynamics January-February 20042004，27，1： | 1 |
| 9 | The cop9 signalosome inhibits p27(kipl) degradation and impedes g1-s phase progression vis deneddylation of scf cull显示文摘 | Yang X Menon S Lykke-Andersen K | 2002 | Curr Biol2002，12，： | 1 |
| 10 | Ensuring greater satisfaction by engineering salesperson response to customer emotions 显示文摘 | Menon K Dube L | 2000 | Journal of Retailing2000，76，3： | 1 |
| 11 | Optimal Trajectory Synthesis for Terrain-Following Flight 显示文摘 | Menon P K A Kim E C | 1991 | Journal of Guidance Control and Dynamics1991，14，4： | 1 |
| 12 | Optimal trajectory synthesis for terrain-following flight 显示文摘 | Menon P K A Kim E Cheng V H L | 1991 | J Guidance1991，14，4： | 1 |
| 13 | Antihyperlipidemic effect of chlorogenic acid and tetrahydrocureumin in rats subjected to dia- betogenic agents 显示文摘 | K Karthikesan L Pari V P Menon | 2010 | Chemico Biological Interact2010，188，3： | 1 |
| 14 | Ensuring greater satisfaction by engineering salesperson response to customer emotions显示文摘 | MENON K DUBE L | 2000 | Journal of Retailing2000，76，3： | 1 |
| 15 | Mechanism of stone formation显示文摘 | Balaji K C Menon M | 1997 | Urol Clin North Am1997，24，1： | 1 |
| 16 | The Technique of Apical Dissection of the Prostate and Urethrovesical Anastomosis in Robotic Radical Prostatectomy显示文摘 | Menon M Hemal A K Tewari A | 2004 | BJU Int2004，93，： | 1 |
| 17 | Former Audit Partners and Abnormal Accruals显示文摘 | WILLIAMS D D | 2004 | The Accounting Review2004，79，10： | 1 |
| 18 | The functional and clinical roles of osteopontin in cancer and metastasis 显示文摘 | Furger K A Menon R K Tuck A B | 2001 | Curr Mol Med2001，1，5： | 1 |
| 19 | Gain-scheduled nonlinear control of Utube steam generator water level 显示文摘 | MENON S K PORLOS A- G | 1992 | Nuclear Science Engineering1992，111，： | 1 |
| 20 | Field Investigation of Child Restraint Systems in Side lmpact Crashes显示文摘 | Arbogast K B Yoganandan G Menon R A | 2005 | Traffic Injury Prevention2005，6，4： | 1 |
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