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| 1 | Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics显示文摘Multiple myeloma is a hematological malignancy inwhich clonal plasma cells proliferate and accumulate within the bone marrow. The presence of osteolytic le-sions due to increased osteoclast(OC) activity and sup-pressed osteoblast(OB) function is characteristic of the disease. The bone marrow mesenchymal stromal cells(MSCs) play a critical role in multiple myeloma patho-physiology, greatly promoting the growth, survival, drug resistance and migration of myeloma cells. Here, we specifically discuss on the relative contribution of MSCs to the pathophysiology of osteolytic lesions in light of the current knowledge of the biology of my-eloma bone disease(MBD), together with the reported genomic, functional and gene expression differences between MSCs derived from myeloma patients(pMSCs) and their healthy counterparts(dMSCs). Being MSCs the progenitors of OBs, pMSCs primarily contribute to the pathogenesis of MBD because of their reduced osteogenic potential consequence of multiple OB inhibi-tory factors and direct interactions with myeloma cells in the bone marrow. Importantly, pMSCs also readily contribute to MBD by promoting OC formation and ac-tivity at various levels(i.e., increasing RANKL to OPG expression, augmenting secretion of activin A, uncou-pling ephrinB2-EphB4 signaling, and through augment-ed production of Wnt5a), thus further contributing to OB/OC uncoupling in osteolytic lesions. In this review, we also look over main signaling pathways involved in the osteogenic differentiation of MSCs and/or OB activity, highlighting amenable therapeutic targets; in parallel, the reported activity of bone-anabolic agents(at preclinical or clinical stage) targeting those signaling pathways is commented. | Antonio Garcia-Gomez Fermin Sanchez-Guijo M Consuelo del Caizo Jesus F San Miguel Mercedes Garayoa | 2014 | World Journal of Stem Cells2014，6，3： | 5 |
| 2 | Implications of Klotho in vascular health and disease显示文摘Cardiovascular disease(CVD) is a prevalent condition in general population and the first cause of death overall. Klotho, a pleiotropic protein related to longevity that acts as a co-receptor of the fibroblast growth factor 23, has been proposed as a key regulator of the development of CVD. In the few clinical studies made, it has been observed a relationship between low levels of soluble Klotho and the occurrence and severity of CVD, as well as a reduction of cardiovascular risk when they are high. Also, different polymorphisms of human Klotho gene have been related to the incidence of cardiovascular events. Moreover, several experimental studies indicate that this protein acts in the maintenance of vascular homeostasis. Klotho improves endothelial dysfunction through promotion of NO production and mediates antiinflammatory and anti-aging effects such as suppression of adhesion molecules expression, attenuation of nuclear factor-kappa B or inhibition of Wnt signaling. Furthermore,this protein is related to the attenuation of vascular calcification as well as prevention of cardiac hypertrophy. The expression of this protein in the vascular wall implies a new scenario for the treatment of vascular disorders. The purpose of this review is to provide an overview of the relationship between the Klotho protein and CVD, in addition to its role in the maintenance of functional vascular integrity. | Ernesto Martín-Núez Javier Donate-Correa Mercedes Muros-de-Fuentes Carmen Mora-Fernández Juan F Navarro-González | 2014 | World Journal of Cardiology2014，6，12： | 4 |
| 3 | Klotho in cardiovascular disease:Current and future perspectives显示文摘Protein Klotho,beyond its role as a regulator of the phosphatemia,is also involved in the maintaining of the cardiovascular health,being associated its alterations with the development of cardiovascular damage and increased morbi-mortality. For all this,nowadays Klotho is the subject of a thorough research which is focused on uncover its intimate mechanisms of action,and in analyzing the utility of its modulation as a potential strategy with clinical applicability. Molecular mechanisms of Klotho are not well understood but an emerging research area links Klotho deficiency with vascular pathology. Changes in this protein have been associated with cardiovascular-related complications like inflammation,vascular calcification,and endothelial dysfunction. All this is particularly relevant if considering the recent discovery of Klotho expression in vascular tissue. | Javier Donate-Correa Ernesto Martin-Nunez Carmen Mora-Fernandez Mercedes Muros-de-Fuentes Nayra Perez-Delgado Juan F Navarro-Gonzalez | 2015 | World Journal of Biological Chemistry2015，6，4： | 4 |
| 4 | Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature显示文摘 | Mercedes Herrera Abul B.M.M.K. Islam Alberto Herrera Paloma Martín Vanesa García Javier Silva Jose M. Garcia Clara Salas Ignacio Casal Antonio García de Herreros Félix Bonilla Cristina Pe?a | 2013 | Clinical Cancer Research2013，，21： | 2 |
| 5 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 6 | Neural stem cells and cholinergic neurons:Regulation by immunolesion and treatment with mitogens,retinoic acid,and nerve growth factor显示文摘 | Laura C Alessandro G Mercedes F | 2003 | Pnas2003，100，12： | 1 |
| 7 | Simple and sequential extractions of heavy metals from different sewage sludges 显示文摘 | Ana F Mercedes L Jose S | 2004 | Chemosphere2004，54，8： | 1 |
| 8 | Application of predictive sliding mode controllers to a solar plant 显示文摘 | Mercedes P P Cristina M C Eduardo F C | 2008 | IEEE Transactions on Control System Technology2008，16，4： | 1 |
| 9 | Particle size distribution in slaughterhouse wastewater before and after coagulation-flocculation 显示文摘 | Maria Isabel Aguilar Sanchis Hose Saez Mercedes lorens Antonio Soler and Juan F Ortuno | 2003 | Environmental Progress2003，22，3： | 1 |
| 10 | Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells 显示文摘 | Garcia-Briones Mercedes Rosas Mafia F Gonzalez-Magaldi Monica | 2006 | Virology2006，349，2006： | 1 |
| 11 | The assessment of sustainable tourism : Application to Spanish coastal destinations 显示文摘 | Blancas F J Mercedes G Mercedes L O Parez F | 2010 | Ecological Indicators2010，10，2： | 1 |
| 12 | The Production of Threose as a Deg- radation Product from L-Ascorbic Acid显示文摘 | Mercedes G L Milton S F | 1992 | Journal of Carbohy- drate Chemistry1992，11，6： | 1 |
| 13 | Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells显示文摘 | Mercedes G B Maria F R Monica G M | 2006 | Virology2006，349，： | 1 |
| 14 | A novel application of three phase hollow fiber based liquid phase microextraction (HF-LPME) for the HPLC determination of two endocrine disrupting compounds (EDCs), n-octylphenol and n-nonylphenol, in environmental waters显示文摘 | MERCEDES V MARIA R RUT F | 2013 | Sci Total Environ2013，443，： | 1 |
| 15 | Reduced Klotho is associated with the presence and severity of coronary artery disease显示文摘 | Juan F Navarro-Gonzrlez Javier Donate-Correa Mercedes Muros de Fuentes ct al | 2014 | Heart2014，100，1： | 1 |
| 16 | Analysis of Acetamiprid in Vegetables Using Gas Chromatography-Tandem Mass Spectrometry显示文摘 | MANUEL M-S MERCEDES M F JAVIER A | 2003 | Analytical Sciences2003，19，5： | 1 |
| 17 | Neural stem cells and cholinergic neurons:Regulation by immunolesion and treatment with mitogens,retinoic acid,and nerve growth factor显示文摘 | Laura C Alessandro G Mercedes F | 2003 | Pnas2003，100，12： | 1 |
| 18 | Heavy metal and arsenic uptake by wild vegetation in the Guadiamar river area after the toxic spill of the Aznalcollar mine 显示文摘 | Mercedes D R Rafael F Comcepcion A | 2002 | Jourual of Biotechnology2002，98，： | 1 |
| 19 | Cancer‐associated fibroblast and M 2 macrophage markers together predict outcome in colorectal cancer patients显示文摘 | Mercedes Herrera Alberto Herrera Gemma Domínguez Javier Silva Vanesa García José M. García Irene Gómez Beatriz Soldevilla Concepción Mu?oz Mariano Provencio Yolanda Campos‐Martin Antonio García de Herreros Ignacio Casal Félix Bonilla Cristina Pe?a | 2013 | Cancer Sci2013，，4： | 1 |
| 20 | Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells 显示文摘 | Mercedes G B Maria F R Monica G M | 2006 | Viology2006，349，： | 1 |
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