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| 1 | Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2显示文摘G 联合蛋白质的受体 kinase (GRK2 ) 2 是调整不同的膜 receptorsand 的重要 serine/threonine-kinase 细胞内部的蛋白质。在胚胎或成年苍蝇的果蝇 Gprk2 的变细导致了体的肌肉,纤维的损失,和不能飞行的 phenotype.In 的有缺点的区别脊椎动物, GRK2 hemizygous 老鼠少些,但是更包含了 hypertrophied 骨胳的肌肉纤维比野类型的 littermates.In C2C12 myoblasts , GRK2 kinase缺乏的异种( K220R )的 overexpression 引起了房间 intoimmature myotubes 的早熟的区别,它在尺寸是更宽的并且包含了更多的熔化原子核,当时 GRK2 overexpression b 熔化事件由提高的 GRK2 层次支持了的损害 differentiationand 少数被 p38MAPK 异种概括,它能由 GRK2 模仿 p38MAPK 的 theinhibitory phosphorylation,而在表示 GRK2 观察的弄钝的区别面对 p38MAPK 小径的一个组成地活跃的在上游的激发器克隆 wasrescued。这些结果建议 thatbalanced GRK2 功能为一个及时、完全的 myogenic 过程是必要的。 | Lucia Garcia-Guerra Rocio Vila-Bedmar Marta Carrasco-Rando Marta Cruces-Sande Mercedes Martin Ana Ruiz-Gomez Mar Ruiz-Gomez Margarita Lorenzo Sonia Fernandez-Veledo Federico Mayor Jr. Cristina Murga Iria Nieto-Vazquez | 2014 | Journal of Molecular Cell Biology2014，8，4： | 3 |
| 2 | Chiral codendrimers derived from poly (propyleneimine) dendrimers (DAB)显示文摘 | Jose Luis Serrano Mercedes Marcos Rafael Martin | 2003 | Chem Mater2003，15，20： | 1 |
| 3 | Albumin-bound paclitaxel as new treatment for metastatic cholangiocarcinoma: A case report显示文摘BACKGROUND Cholangiocarcinomas are rare and very aggressive tumors.Most patients have advanced-stage or unresectable disease at presentation,and the systemic therapies have limited efficacy.Albumin-bound paclitaxel(nab-paclitaxel)is a solvent-free taxane that has been approved for the treatment of some cancers such as breast,non-small cell lung and pancreatic cancer,however it has not been applied to treat cholangiocarcinoma.We have both preclinical and clinical evidence of the efficacy of nab-paclitaxel in cholangiocarcinoma,yet no phase 3 trials have been made.CASE SUMMARY A 63-year-old man was diagnosed in December 2016 with stage III B intrahepatic cholangiocarcinoma.Surgery was performed,followed by adjuvant chemotherapy treatment with capecitabine and gemcitabine;although,the gemcitabine was suspended due to allergic reaction after two cycles.In April 2019,metastatic cholangiocarcinoma relapse was diagnosed,and a first-line treatment with FOLFOX scheme was started.Eight cycles were administered,producing an initial clinical improvement and decrease in blood tumor marker levels.Radiological and serological progression was noted in September 2019.As a second-line treatment,FOLFIRI was not recommended due to risk of worsening the patient’s tumor-related diarrhea.A combination therapy with gemcitabine was not feasible,as the patient had previously suffered from an allergic reaction to this treatment.We decided to use nab-paclitaxel as a second-line treatment,and four cycles were administered.Both clinical and serological responses were observed,and a radiological mixed response was also noted.CONCLUSION Advanced cholangiocarcinoma could be treated with nab-paclitaxel monotherapy,which should be studied in combination with other types of treatment(chemotherapy,fibroblast growth factor receptor inhibitors). | Roberto Martin Huertas Raquel Fuentes-Mateos Juan Jose Serrano Domingo Elena Corral de la Fuente Mercedes Rodríguez-Garrote | 2020 | World Journal of Clinical Oncology2020，11，10： | 1 |
| 4 | Multilevel competing risk models to evaluate the risk of nosocomial infection显示文摘 | Martin Wolkewitz Ben S Cooper Mercedes Palomar-Martinez | 2014 | Crit Care2014，18，2： | 1 |
| 5 | Cancer‐associated fibroblast and M 2 macrophage markers together predict outcome in colorectal cancer patients显示文摘 | Mercedes Herrera Alberto Herrera Gemma Domínguez Javier Silva Vanesa García José M. García Irene Gómez Beatriz Soldevilla Concepción Mu?oz Mariano Provencio Yolanda Campos‐Martin Antonio García de Herreros Ignacio Casal Félix Bonilla Cristina Pe?a | 2013 | Cancer Sci2013，，4： | 1 |
| 6 | Analysis of cows' ,ewes' and goats' milk mixtures by capillary electrophoresis:quantification by multivariate regression analysis 显示文摘 | Elena Molina Pedro Jesus Martin - Alvarez Mercedes Ramose | 1999 | International Dairy1999，9，1： | 1 |
| 7 | Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study显示文摘 | Marie-Laurence Lambert Carl Suetens Anne Savey Mercedes Palomar Michael Hiesmayr Ingrid Morales Antonella Agodi Uwe Frank Karl Mertens Martin Schumacher Martin Wolkewitz | 2011 | The Lancet Infectious Diseases2011，，1： | 1 |
| 8 | Apparent diffusion coefficient and vascular signal fraction measurements with magnetic resonance imaging: feasibility in metastatic ovarian cancer at 3 Tesla显示文摘 | Evis Sala Andrew N. Priest Masako Kataoka Martin J. Graves Mary A. McLean Ilse Joubert John R. Griffiths Robin A. F. Crawford Mercedes Jimenez-Linan Helena M. Earl James D. Brenton David J. Lomas | 2010 | European Radiology2010，，2： | 1 |
| 9 | Vitamin D as a Cytokine and Hematopoetic Factor显示文摘 | Martin Hewison Mercedes A. Gacad Jacques Lemire John S. Adams | 2001 | Reviews in Endocrine and Metabolic Disorders2001，，2： | 1 |
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