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| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | B-type natriuretic peptide(BNP)and N-terminal proBNP in patients with end-stage heart failure supported by a left ventricular assist device显示文摘 | Hans K Mery B Hans K | 2004 | Clin Chem2004，50，9： | 1 |
| 3 | B-type natriuretic peptide (BNP) and N-terminal proBNP in patients with end-stage heart failure supported by a leftventricular assist device显示文摘 | Hans K Mery B | 2004 | Clin Chem2004，50，： | 1 |
| 4 | Natural polymorphism affecting learning and memory in Drosophila显示文摘 | MERY F BELAY A T SO A K | 2007 | Proc Natl Acad Sci USA2007，104，13： | 1 |
| 5 | Methylene blue as a novel electrochemical hybridization indicator 显示文摘 | Erdem A Kerman K Merie B | 2001 | E- lectroanalysis2001，13，3： | 1 |
| 6 | A multicom- pound LC-MS/MS method for the screening of my- cotoxins in grains显示文摘 | Meri K Kokkonen Marika N Jestoi | 2009 | Food Analytical Methods2009，，2： | 1 |
| 7 | B -type natriuretic peptide(BNP) and N -ter- minal proBNP in patients with end - stage heart failure suported by a left ventrieular assist device显示文摘 | Hans K Mery B | 2004 | Clin ehem2004，50，9： | 1 |
| 8 | B-type natriuretic peptide ( BNP ) and N-terminal proBNP in patients with end-stage heart failuresupported by a left ventricular assist device 显示文摘 | Hans K Mery B | 2004 | Clin Chem2004，50，9： | 1 |
| 9 | The importance of combined coronary anglography and renal angiography in patients with hypertension and isehemie heart disease显示文摘 | Helvaci A Aalet K Merie M | 1996 | Ist Tip Faku Metro1996，59，： | 1 |
| 10 | Evaluation of plasma chemerin levels in patients with non-dipper blood pressure patterns显示文摘 | Merie M Soylu K Avei B | 2014 | Med Sci Monit2014，20，9： | 1 |
| 11 | Serum complement and familial combined hyperlipidemia显示文摘 | Ylitalo K Porkka KV Meri S Nuotio I Suurinkeroinen L Vakkilainen J | 1997 | Atherosclerosis1997，129，2： | 1 |
| 12 | B-type natriuretic pettide (BNP) and N-terminal proBNP in patients with end-stage heart failure supported by a left ventrieular assist device 显示文摘 | Hans K Mery B | 2004 | Clin Chem2004，50，9： | 1 |
| 13 | Serum C3 but not plasma acylation stimulating protein is elevated in finnish patients with familial combined hyperlipidemia显示文摘 | Ylitalo K Pajukanta P Meri S Cantor RM Mero-Matikainen N Vakkilainen J | 2001 | Arterioscler Thromb Vasc Biol2001，21，5： | 1 |
| 14 | Serum C3 but not plasma acylatien- stimulating protein is elevated in Finnish patients with familial combined hyperlipidemia显示文摘 | Ylitalo K Pajukanta P Meri S | 2001 | Arterioscler Thromb Vase Biol2001，21，： | 1 |
| 15 | Postcardiotomy and postinfarctiong syndrome a theory显示文摘 | BURCH G E MERI S VERKKALA K el al | 1970 | Am Heart1970，80，： | 1 |
| 16 | Absence of fetal cell microchimerism in cutaneous lesions of lupus erythematosus显示文摘 | Khosrotehrani K Mery L Aractingi S | 2005 | Ann Rheum Dis2005，64，： | 1 |
| 17 | Complement levels and C3 breakdown products in open - heart surgery:association of C3 conversion with the postpericardiotomy syndrome 显示文摘 | MERI S VERKKALA K MIETTINEN A | 1985 | Clin Exp lmmunol1985，60，3： | 1 |
| 18 | B-type natriuretic peptide(BNP) and N-terminal proBNP in patients with end-stage heart failure suported by a left ventricular assist device显示文摘 | HANS K MERY B | 2004 | Clin Chem2004，50，9： | 1 |
| 19 | Indoor and outdoor panicle size characterization at a family house in Espoo-Finland 显示文摘 | T Hussein K H?meri MSA Heikkinen | 2005 | Atmospheric Environment2005，39，20： | 1 |
| 20 | Color measurement in L^* a^* b^* units from RGB digital images 显示文摘 | Leon K Mery D Pedreschi F | 2006 | Food Research International2006，39，10： | 1 |
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