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| 1 | Immune monitoring of immunosuppression withdrawal of liver transplant recipients 显示文摘 | Garcfa de la Garza R Sarobe P Merino J | 2015 | Transpl Immunol2015，33，2： | 1 |
| 2 | Value of gross cystic disease fluid protein-15 in distinguishing metastatic breast carcinomas among poorly differentiated neoplasms involving the ovary显示文摘 | Monteagudo C Merino MJ La Porte N | 1991 | Hum Pathol1991，22，4： | 1 |
| 3 | Bacteriologic findings in patients with chronic sinusitis 显示文摘 | Merino LA Ronconi MC Hrenuk GE de Pepe MG | 2003 | Prim Care2003，30，1： | 1 |
| 4 | Bacteriologic findings in patients with chronic sinusitis显示文摘 | Merino LA Ronconi MC Hrenuk GE | 2003 | Ear Nose Throat J2003，82，10： | 1 |
| 5 | ZrO2-Al2O3 eutectic plates produced by laser zone melting 显示文摘 | LARREA A De la FUENTE G F MERINO R I | 2002 | J Eur Ceram Soc2002，22，： | 1 |
| 6 | Bacteriologic findings in patients with chronic sinusitis 显示文摘 | Merino LA Ronconi MC Hrenuk GE | 2003 | Prim Care2003，，1： | 1 |
| 7 | Bacteriologic findings in patients with chronic sinusitis显示文摘 | Merino LA | 2003 | Ear Nose Throat J2003，82，： | 1 |
| 8 | 都市集会中心显示文摘项目地点:西班牙塞维里亚项目类型:城市改造开工日期:2005年5月该项目的目的是改造传统城市广场,融合文化与商业要素,打造一个综合公共中心。 | Jürgen Mayer H J. Mayer H. José de la Pea Carlos Merino | 2010 | 世界建筑导报2010，，1： | 0 |
| 9 | Topical Calendula officinalis L.inhibits inflammatory pain through antioxidant,anti-inflammatory and peripheral opioid mechanisms显示文摘Objective The present study evaluated the antinociceptive activity of Calendula officinalis L.(Ca)cream on inflammatory hypernociception.Methods Creams with different Ca concentrations were tested for their ability to ameliorate pain-related behavior and edema in rats using formalin test,carrageenan(Cg)-induced acute inflammation model,bradykinin(BK)-induced acute inflammation model,and complete Freund’s adjuvant(CFA)-induced chronic inflammation model.Using the formalin test,we also examined the implication of peripheral opioid receptors in the antinociceptive mechanisms of Ca cream,by means of Q-naloxone,a peripherally acting nonselective opioid antagonist.Furthermore,the effects of Ca cream compared with diclofenac on BK-induced edema were examined when the kininase II in tissue was preserved or inhibited by captopril.The local production of redox biomarkers in formalin model,tumor necrosis factor-α(TNF-α)in Cg model and histopathological changes in CFA model were also evaluated.Results A single application of Ca cream at a dose of 10%or 30%(w/w)decreased the formalin-induced licking/biting behavior during both phases of this test in a Q-naloxone-sensitive manner.This effect was associated with the reduction of oxidative stress in the injured paw and the edema associated with the later phase of formalin-induced pain.A single application of Ca cream(10%or 30%)reduced paw edema and thermal hypernociception in Cg-induced acute inflammation,corresponding with a local decrease in TNF-α.Ca cream also inhibited BK-induced spontaneous nociceptive behavior and paw inflammation in both paradigms studied.Repeated applications of Ca cream also decreased CFA-induced chronic inflammation,mechanical hypernociception and histopathological changes in the paw.Conclusion These results reveal the topical antinociceptive and antiedematogenic effects of Ca cream.A modulatory action on peripheral opioid receptors associated with its antioxidant mechanism may be involved,at least in part,in its analgesic effects.These findings may have an impact on the clinical management of painful inflammatory diseases. | Bárbara B.Garrido-Suárez Gabino Garrido Addis Bellma Menéndez Nelson Merino Odalys Valdés Nilia de la Paz Aylema Romero Livan Delgado Miguel D.Fernández Octavio Piñeros RenéDelgado-Hernández | 2023 | Journal of Integrative Medicine2023，21，1： | 0 |
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