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| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 3 | The muscle - specific enolase is an early marker of human myogene- sis显示文摘 | FOUGEROUSSE F EDOM VOVARD F MERKULOVA T | 2001 | J Muscle Res Cell Motil2001，22，6： | 1 |
| 4 | The muscle specific enolase is an early marker of human myogenesis 显示文摘 | Fougerousse F Edom-Vovard F Merkulova T | 2001 | Muscle Res Cell Motil2001，22，6： | 1 |
| 5 | The beta enolase subunit displays three different patterus of mi- croheterogeneity in human striated muscle 显示文摘 | MERKULOVA T THORNELL L E BUTLER BROWNE G | 1999 | J Muscle Res Cell Motil1999，20，1： | 1 |
| 6 | A novel 45 kDa secretory protein from rat olfactory epithelium:primary structure and localization显示文摘 | Merkulova M I Andreeva S G Shuvaeva T M | | 0，，1： | 1 |
| 7 | Respiratory Responses to Microinjections of Leptin into the Solitary Tract Nucleus 显示文摘 | Inyushkin AN Inyushkina EM Merkulova NA | 2009 | Neurosci Behav Physio12009，39，3： | 1 |
| 8 | Features of the Separation of Pesticides of Different Classes Byreversed Phase High-performance Chromatography显示文摘 | MERKULOVA N L SHAPOVALOVA E N Shpigun O A | 2006 | Journal of Analytical Chemistry2006，61，4： | 1 |
| 9 | Secretion of the mammalian Seel4p-like phosphoinositide-binding p45 protein显示文摘 | Merkulova M Huynh H Radchenko V | | 0，，21： | 1 |
| 10 | Functional expression and properties of Sec14p-like protein with molecular mass 45 kD from rat olfactory epithelium显示文摘 | Radchenko V V Merkulova M I Shuvaeva T M | | 0，，12： | 1 |
| 11 | The musclespecific enolase is an early marker of human myogenesis显示文摘 | Fougerousse F Edom-Vovard F Merkulova T | 2001 | J Muscle Res Cell Motil2001，22，6： | 1 |
| 12 | The muscle specific-enolase is an early marker of human myogenesis显示文摘 | Fougerousse F Edom-Vovard F Merkulova T | 2001 | J Muscle Res Cell Motil2001，22，6： | 1 |
| 13 | Early stages of hepatic carcinogenesis after vagotomy显示文摘 | Dubovaia TK Kobliakov VA Merkulova IB | 1989 | Arkn Anat Gistol Embriol1989，97，7： | 1 |
| 14 | High-speed analysis of catecholamines in plasma by medium-pressure Mu-LC with an amperometric detector显示文摘 | RUBAN V F PETUNIN S N MERKULOVA N C | 1996 | Biomed Chromatogr1996，10，： | 1 |
| 15 | Differential modulation of alpha, beta and gamma enolase isoforms in regenerating mouse skeletal musele显示文摘 | Merkulova T Dehaupas M Nevers M C | 2000 | Biochem2000，267，： | 1 |
| 16 | rSNP__Guide,a database system for analysis of transcription factor binding to target sequences:application of SNPs and site-directed mutations显示文摘 | Merkulova T L Vasiliev G V | 2001 | Nucleic Acids Research2001，29，1： | 1 |
| 17 | Oxidative stress in duces angiogenesis by activating TLR2 with novel endogenous lig- ands显示文摘 | West XZ Malinin NL Merkulova AA | 2010 | Nature2010，467，7318： | 1 |
| 18 | HGF receptor up - regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro显示文摘 | Ding S Merkulova - Rainon T Han ZC | 2003 | Blood2003，101，12： | 1 |
| 19 | Spontaneous reperfusion of the infarct-related artery in patients with ST elevated myocardial infarction显示文摘 | Ruda Mla Kuz'min AI Merkulova IN | 2009 | Ter Arkh2009，81，5： | 1 |
| 20 | The muscle-specific enolase is an early marker of hu- man myogenesis显示文摘 | Fougerousse F Edom-Vovard F Merkulova T | 2001 | J Muscle Res Cell Motil2001，22，6： | 1 |
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