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| 1 | Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis显示文摘AIM:To test the hypothesis that histamine 3 receptor (H3R)activation during Helicobacter infection inhibits gastric acid secretion in vivo and in vitro.METHODS:Helicobacter felis(H.felis)infected and uninfected C57Bl/6 mice were infused with either PBS or the H3 receptor antagonist thioperamide(THIO)for 12 wk.After treatment,mice were analyzed for morphological changes and gastric acid content.Total RNA was prepared from the stomachs of each group and analyzed for changes in somatostatin and gastrin mRNA abundance by real time-polymerase chain reaction(RTPCR).Location of H3 receptors in the stomach was analyzed by co-localization using antibodies specific for the H3 receptor and parietal cell marker H + ,K + -ATPase βsubunit. RESULTS:Inflammation and parietal cell atrophy was observed after 12 wk of H.felis infection.Interestingly, treatment with the H3R antagonist thioperamide(THIO) prior to and during infection prevented H.felis-induced inflammation and atrophy.Compared to the uninfected controls,infected mice also had significantly decreased gastric acid.After eradication of H.felis with THIO treatment,gastric acidity was restored.Compared to the control mice,somatostatin mRNA abundance was decreased while gastrin gene expression was elevated during infection.Despite elevated gastric acid levels, after eradication of H.felis with THIO,somatostatin mRNA was elevated whereas gastrin mRNA was suppressed.Immunofluorescence revealed the presence of H3 receptors on the parietal cells,somatostatin-secreting D-cells as well as the inflammatory cells. CONCLUSION:This study shows that during H.felis infection,gastric acidity is suppressed as a consequence of an inhibitory effect on the parietal cell by H3R activation.The stimulation of gastric mucosal H3Rs increases gastrin expression and release by inhibiting release of somatostatin. | Yana Zavros Nisreen Mesiwala Meghna Waghray Andrea Todisco Arthur Shulkes Juanita L Merchant | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，5： | 2 |
| 2 | Long- term outcome of superficial temporal artery - middle cerebral artery bypass for patients with moyamoya disease in the US显示文摘 | Mesiwala A H Sviri G Fatemi N | 2008 | Neurosurg Focus2008，24，2： | 1 |
| 3 | Long-term out- come of superficial temporal artery-middle cerebral ar- tery bypass for patients with moyamoya disease in the US显示文摘 | Mesiwala A H Sviri G Fatemi N | 2008 | Neurosurg Focus2008，24，2： | 1 |
| 4 | Long-term outcome of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the US显示文摘 | Mesiwala AH Sviri G Fatemi N | | 0，，02： | 1 |
| 5 | Long-term outcome of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the US 显示文摘 | Mesiwala AH Sviri G Fatemi N | 2008 | Neurosurg Focus2008，24，2： | 1 |
| 6 | Long-term outcome of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the US 显示文摘 | Mesiwala AH Sviri G Fatemi N | 2008 | Neuro- surg Focus2008，24，2： | 1 |
| 7 | High- intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo显示文摘 | Mesiwala AH Farrell L Wenzel HJ | 2002 | Ultrasound Med Bi- ol2002，28，3： | 1 |
| 8 | High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo显示文摘 | Mesiwala AH Farrell L Wenzel HJ | 2002 | Ultrasound Med Biol2002，28，3： | 1 |
| 9 | long-term outcome of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the US显示文摘 | Mesiwala AH Sviri G Fatemi N | 2008 | Neurosurg Focus2008，24，： | 1 |
| 10 | Long-term outcome of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the us显示文摘 | Mesiwala AH Sviri G Fatemi N | 2008 | Neurosurgical Focus2008，24，： | 1 |
| 11 | Long-term outcome of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the US显示文摘 | Mesiwala AH Sviri G Fatemi N | 2008 | Neurosurg Focus2008，24，： | 1 |
| 12 | The diagonal ventricular dimension: a method for predicting shunt malfunction on the basis of changes in vantricular size显示文摘 | Avellino AM Ellenbogen RG | 2002 | Neurosurgery2002，50，6： | 1 |
| 13 | Long-term outcome of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the US 显示文摘 | Mesiwala AH Sviri G Fatemi N | 2008 | Neurosurg Focus2008，24，2： | 1 |
| 14 | Long-term outcome of superficial temporal artery middle cerebral artery bypass for patients with moyamoya disease in the US显示文摘 | Mesiwala AH Sviri G Fatemi N | 2008 | Neuro- surg Focus2008，24，： | 1 |
| 15 | Cerebrovascular effects of the bradykinin analog RMP in normal and irradiated dog brain 显示文摘 | Fike JR Gobbel GT Mesiwala AH | 1998 | J Neuro Oncol1998，37，2： | 1 |
| 16 | Long-term out- come of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the US显示文摘 | Mesiwala AH Sviri G Fatemi N | 2008 | Neurusurg Focus2008，24，2： | 1 |
| 17 | Long-term outcome of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the US显示文摘 | Mesiwala AH Sviri G Fatemi N | 2008 | Neurosurg Focus2008，24，2： | 1 |
| 18 | Long-term outcome of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the US 显示文摘 | Mesiwala AH Sviri G Fatemi N | 2008 | Neurosurg Focus2008，24，2： | 1 |
| 19 | High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo显示文摘 | Mesiwala AH Farrell L Wenzel HJ | 2002 | Ultrasound Med Biol2002，28，3： | 1 |
| 20 | Diagnostic power of optic disc morphology, peripapillary retinal nerve fiber layer thickness, and maeular inner retinal layer thickness in glaucoma diagnosis with fourier-domain optical coherence tomography显示文摘 | Huang JY Pekmezci M Mesiwala N | 2011 | J Glaucoma2011，20，2： | 1 |
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