| 5 | Chronic hepatitis C infection in a patient with bone marrow hypoplasia显示文摘Chronic hepatitis C virus(HCV) infection is associated with multifarious extra-hepatic manifestations;the most described and discussed being mixed cryoglob-ulinemia which is strongly related to B-cell lympho-proliferative disorders(LPDs).We present a case of chronic HCV infection and mixed cryoglobulinemia,with minimal liver involvement.The case is a 53-year-old patient who was diagnosed as having bone marrow hypoplasia at the age of three.She received several blood transfusions to normalize her haemoglobin.At the age of 31,she was diagnosed with rheumatoid ar-thritis on account of her diffuse joint pain and inflam-mation,elevated rheumatoid factor(RF) and Raynaud's phenomenon.Twenty years later,monoclonal gam-mopathy of IgG Lambda(one year later,changed to IgM Kappa) was detected during a routine examina-tion.A bone marrow biopsy showed hypoplasia,Kappa positive B-lymphocytes and low-grade malignant lym-phoma cells.PCR of the bone marrow aspirate was not contributory.No treatment was initiated owing to herpoor bone marrow function and she is under regular follow-up. | S Bethlen K Chandrikakumari L de Leval JB Giot D Mukeba P Leonard F Frippiat C Meuris J Delwaide M Moutschen | 2008 | World Journal of Gastroenterology2008，14，26： | 0 |
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