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| 1 | Pathophysiology and prevention of postoperative peritoneal adhesions显示文摘Peritoneal adhesions represent an important clinical challenge in gastrointestinal surgery. Peritoneal adhesions are a consequence of peritoneal irritation by infection or surgical trauma, and may be considered as the pathological part of healing following any peritoneal injury, particularly due to abdominal surgery. The balance between fi brin deposition and degradation is critical in determining normal peritoneal healing or adhesion formation. Postoperative peritoneal adhesions are a major cause of morbidity resulting in multiple complications, many of which may manifest several years after the initial surgical procedure. In addition to acute small bowel obstruction, peritoneal adhesions may cause pelvic or abdominal pain, and infertility. In this paper, the authors reviewed the epidemiology, pathogenesis and various prevention strategies of adhesion formation, using Medline and PubMed search. Several preventive agents against postoperative peri-toneal adhesions have been investigated. Their role aims in activating fi brinolysis, hampering coagulation, diminishing the inflammatory response, inhibiting col-lagen synthesis or creating a barrier between adjacentwound surfaces. Their results are encouraging but most of them are contradictory and achieved mostly in animal model. Until additional fi ndings from future clinical researches, only a meticulous surgery can be recommended to reduce unnecessary morbidity and mortality rates from these untoward effects of surgery. In the current state of knowledge, pre-clinical or clini-cal studies are still necessary to evaluate the effective-ness of the several proposed prevention strategies of postoperative peritoneal adhesions. | Willy Arung Michel Meurisse Olivier Detry | 2011 | World Journal of Gastroenterology2011，17，41： | 46 |
| 2 | Brain edema and intracranial hypertension in fulminant hepatic failure:Pathophysiology and management显示文摘Intracranial hypertension is a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure. The etiology of this intracranial hypertension is not fully determined, and is probably multifactorial, combining a cytotoxic brain edema due to the astrocytic accumulation of glutamine, and an increase in cerebral blood volume and cerebral blood flow, in part due to inflammation, to glutamine and to toxic products of the diseased liver. Validated methods to control intracranial hypertension in fulminant hepatic failure patients mainly include mannitol, hypertonic saline, indomethacin, thiopental, and hyperventilation. However all these measures are often not sufficient in absence of liver transplantation, the only curative treatment of intracranial hypertension in fulminant hepatic failure to date. Induced moderate hypothermia seems very promising in this setting, but has to be validated by a controlled, randomized study. Artificial liver support systems have been under investigation for many decades. The bioartificial liver, based on both detoxification and swine liver cells, has shown some efficacy on reduction of intracranial pressure but did not show survival benefit in a controlled, randomized study. The Molecular Adsorbents Recirculating System has shown some efficacy in decreasing intracranial pressure in an animal model of liver failure, but has still to be evaluated in a phase Ⅲ trial. | Olivier Detry Arnaud De Roover Pierre Honoré Michel Meurisse | 2006 | World Journal of Gastroenterology2006，12，46： | 12 |
| 3 | Carcinoid tumor of the appendix: A consecutive series from 1237 appendectomies显示文摘AIM: To report the experience of the CHU Sart Tilman, University of Liège, Belgium, in the management of appendiceal carinoid tumor. METHODS: A retrospective review of 1237 appendecto- mies performed in one single centre from January 2000 to May 2004, was undertaken. Analysis of demographic data, clinical presentation, histopathology, operative re- ports and outcome was presented. RESULTS: Among the 1237 appendectomies, 5 appen- diceal carcinoid tumors were identified (0.4%) in 4 male and 1 female patients, with a mean age of 29.2 years (range: 6-82 years). Acute appendicitis was the clinical presentation for all patients. Four patients underwent open appendectomy and one a laparoscopic procedure. One patient was reoperated to complete the excision of mesoappendix. All tumors were located at the tip of the appendix with a mean diameter of 0.6 cm (range: 0.3-1.0 cm). No adjuvant therapy was performed. All patients were alive and disease-free during a mean follow-up of 33 mo. CONCLUSION: Appendiceal carcinoid tumor most of- ten presents as appendicitis. In most cases, it is found incidentally during appendectomies and its diagnosis is rarely suspected before histological examination. Appen- diceal carcinoid tumor can be managed by simple appen- dectomy and resection of the mesoappendix, if its size is ≤ 1 cm. | Vincent Tchana-Sato Olivier Detry Marc Polus Albert Thiry Bernard Detroz Sylvie Maweja Etienne Hamoir Thierry Defechereux Carla Coimbra Arnaud De Roover Michel Meurisse Pierre Honoré | 2006 | World Journal of Gastroenterology2006，12，41： | 8 |
| 4 | Donation after cardio-circulatory death liver transplantation显示文摘The renewed interest in donation after cardio-circulatory death (DCD) started in the 1990s following the limited success of the transplant community to expand the donation after brain-death (DBD) organ supply and following the request of potential DCD families. Since then, DCD organ procurement and transplantation activities have rapidly expanded, particularly for nonvital organs, like kidneys. In liver transplantation (LT), DCD donors are a valuable organ source that helps to decrease the mortality rate on the waiting lists and to increase the availability of organs for transplantation despite a higher risk of early graft dysfunction, more frequent vascular and ischemia-type biliary lesions, higher rates of re-listing and re-transplantation and lower graft survival, which are obviously due to theinevitable warm ischemia occurring during the declaration of death and organ retrieval process. Experimental strategies intervening in both donors and recipients at different phases of the transplantation process have focused on the attenuation of ischemia-reperfusion injury and already gained encouraging results, and some of them have found their way from pre-clinical success into clinical reality. The future of DCD-LT is promising. Concerted efforts should concentrate on the identification of suitable donors (probably Maastricht category Ⅲ DCD donors), better donor and recipient matching (high risk donors to low risk recipients), use of advanced organ preservation techniques (oxygenated hypothermic machine perfusion, normothermic machine perfusion, venous systemic oxygen persufflation), and pharmacological modulation (probably a multi-factorial biologic modulation strategy) so that DCD liver allografts could be safely utilized and attain equivalent results as DBD-LT. | Hieu Le Dinh Arnaud de Roover Abdour Kaba Séverine Lauwick Jean Joris Jean Delwaide Pierre Honoré Michel Meurisse Olivier Detry | 2012 | World Journal of Gastroenterology2012，18，33： | 6 |
| 5 | Prognostic value of ^(18)F-FDG PET/CT in liver transplantation for hepatocarcinoma显示文摘AIM:To evaluate the prognostic value of pretreatment F D G p o s i t r o n e m i s s i o n t o m o g ra p h y c o m p u t e d tomography(PET-CT) in patients with hepatocarcinoma treated by liver transplantation(LT).METHODS:The authors retrospectively analyzed the data of 27 patients(mean age 58 ± 9 years) who underwent FDG PET-CT before LT for hepatocarcinoma.Mean follow-up was 26 ± 18 mo.The FDG PET/CT was performed according to a standard clinical protocol:4 MBq FDG/kg body weight,uptake 60 min,low-dose non-enhanced CT.The authors measured the SUVmax and SUVmean of the tumor and the normal liver.The tumor/liver activity ratios(RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors:MILAN,CLIP,OKUDA,TNM stage,alphafoetoprotein level,portal thrombosis,size of the largest nodule,tumor differentiation,microvascular invasion,underlying cirrhosis and liver function.RESULTS:Overall and recurrence free survivals were80.7%and 67.4%at 3 years,and 70.6%and 67.4%at 5 years,respectively.According to a multivariate Cox model,only FDG PET/CT RSUVmax predicted recurrence free survival.Even though the MILAN criteria alone were not predictive,it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax<1.15 relapsed.CONCLUSION:FDG PET/CT with an RSUVmax cutoff value of 1.15 is a strong prognostic factor for recurrence and death in patients with HCC treated by LT in this retrospective series.Further prospectivestudies should test whether this metabolic index should be systematically included in the preoperative assessment. | Olivier Detry Laurence Govaerts Arnaud Deroover Morgan Vandermeulen Nicolas Meurisse Serge Malenga Noella Bletard Charles Mbendi Anne Lamproye Pierre Honoré Paul Meunier Jean Delwaide Roland Hustinx | 2015 | World Journal of Gastroenterology2015，21，10： | 5 |
| 6 | Donor age as a risk factor in donation after circulatory death liver transplantation in a controlled withdrawal protocol programme显示文摘 | O. Detry A. Deroover N. Meurisse M. F. Hans J. Delwaide S. Lauwick A. Kaba J. Joris M. Meurisse P. Honoré | 2014 | Br J Surg2014，，7： | 1 |
| 7 | Pathophysiology and prevention of postoperative peritoneal adhesions 显示文摘 | Arung W Meurisse M Detry O | 2011 | World journal of gastroenterology : WJG2011，，17： | 1 |
| 8 | Outcomes of liver transplantations using donations after circulatory death: a single-center experience 显示文摘 | Meurisse N Vanden Bussche S Jochmans I | 2012 | Transplant Proc2012，44，9： | 1 |
| 9 | Donor age as a risk factor in donation after circulatory death liver transplantation in a controlled withdrawal protocol programme显示文摘 | Detry O Deroover A Meurisse N | 2014 | Br J Surg2014，101，7： | 1 |
| 10 | Contribu-tion of doners after cardiac death to the deceased donorpool 2002 to 2009 University of Liege experience显示文摘 | Ledinh H Meurisse N Delbouile M H ef al | 2010 | Transplant Proc2010，42，10： | 1 |
| 11 | Multi-agent Based Simulation: Where Are the Agents? 显示文摘 | DROGOUL A VANBERGUE D MEURISSE T | 2003 | Subseries of Lecture Notes in Computer Science2003，，2581： | 1 |
| 12 | Maternal experience influences the establishment of visual/auditory but not olfactory recognition of the newborn lamb by ewes at parturition显示文摘 | Keller M Meurisse M Poindron P | | 0，，3： | 1 |
| 13 | Analysis of Oil Supply Phenomena by Sintered Porous Reservoirs显示文摘 | Marcherd a M Meurisse a M- H Vergnea P | 2001 | Tribology Letters2001，3，10： | 1 |
| 14 | Donor age as a risk factor in donation after circulatory death liver transplantation in a controlled withdrawal protocol programme显示文摘 | Detry O Deroover A Meurisse N | 2014 | Br J Surg2014，101，7： | 1 |
| 15 | Estradiol receptoralpha expression in hypothalamic and limbic regions of ewes is influenced by physiological state and maternal experience显示文摘 | Meurisse M Gonzalez A Delsol G | | 0，，1： | 1 |
| 16 | Analysis of oil supply phenomena by sintered porous reservoirs显示文摘 | Marchetti M Meurisse M H Vergne P | 2001 | Tribology Letters2001，10，16： | 1 |
| 17 | Analysis of oil supply phenomena by sintered porous reservoirs 显示文摘 | Marchetti M Meurisse M H Yergne P | 2001 | Tribology Letters2001，10，3： | 1 |
| 18 | On the second-order statistics of the EVD of sample covariance matrices-Application to the detection of noncircular or/and nonGaussian components显示文摘 | DELMAS J P MEURISSE Y | | 0，，09： | 1 |
| 19 | Polymers with mesogenic elements and flexible spaeers in the main chain:Aromatic-aliphatic polyesters显示文摘 | Meurisse P Noel C Monnerie L | | 0，，： | 1 |
| 20 | Persisting perfusion defect in transient ischemic attacks:a new clinically useful subgroup?显示文摘 | Laloux P Jamart J Meurisse H | 1996 | Stroke1996，27，3： | 1 |
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