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| 1 | Vitamin D deficiency and hepatitis viruses-associated liver diseases:a literature review显示文摘The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses(HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response(SVR) to interferon(IFN) plus ribavirin(RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBVand HCV-related chronic liver diseases. Furthermore,current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients. | Nghiem Xuan Hoan Hoang Van Tong Le Huu Song Christian G Meyer Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，4： | 9 |
| 2 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 3 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
| 4 | Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia显示文摘 | Meyer JA Wang J Hogan LE | 2013 | Nat Genet2013，45，3： | 1 |
| 5 | The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain 显示文摘 | Meyer MD Decker MW Rueter LE Anderson DJ Dart M J Kim KH | 2000 | Eur J Pharmacol2000，93，： | 1 |
| 6 | Experimental demonstration of surface selection rules for SERS on flat metallic surfaces 显示文摘 | LE Ru E C MEYER S ARTUR C | 2011 | Chemical Communications2011，47，13： | 1 |
| 7 | Ambulatory continuous femora nerve blocks decrease time to discharge readiness after tricom- partmenttotal knee arthroplasty: a randomized,triple-masked, placebocontrolled study 显示文摘 | Ilfeld B M Le L T Meyer R S | 2008 | Anesthesiology2008，108，4： | 1 |
| 8 | Management of common bile duct stones in a single opeation combining laparoscopic cholecystectomy and perioperative endoscopic sphincterotomy 显示文摘 | C MEYER J VO HUU LE S ROHR | 1999 | Surg Endosc1999，13，： | 1 |
| 9 | Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia 显示文摘 | Meyer JA Wang J Hogan LE | 2013 | Nat Genet2013，45，3： | 1 |
| 10 | Impact of all evidence-based medi-cine cur- riculum on medical students' attitude and skills 显示文摘 | Dorsch Aiyer MK Meyer LE | 2004 | J Med Libr Assoc2004，92，4： | 1 |
| 11 | Judgments about collision in younger and older drives 显示文摘 | Delucia P R Bleckley M K Meyer Le | 2003 | Transport Res Part2003，6，： | 1 |
| 12 | Ambulatory continuous femoral nerve blocks decrease time to discharge readiness after tricompartnent total knee arthroplasty:a randomized triplemasked,placebo controlled study显示文摘 | Ilfeld BM Le LT Meyer RS | 2008 | Anesthesiology2008，108，4： | 1 |
| 13 | Surface enhanced Raman scattering enhancement factors: a comprehensive study显示文摘 | Le Ru E C glackie E Meyer M | 2007 | The Journal of Physi- cal Chemistry C2007，111，13： | 1 |
| 14 | Does human leukocyte antigen matching influence the outcome of lung transplantation? An analysis of 3549 lung transplantations显示文摘 | Quantz MA Bennett LE Meyer DM | 2000 | J Heart Lung Transplant2000，19，5： | 1 |
| 15 | Ambulatory continuous femoral nerve blocks decrease time to discharge readiness af- ter tricompartment total knee arthroplasty: a randomized, tri- ple-masked, placebo-controlled study 显示文摘 | Ilfeld BM Le LT Meyer RS | 2008 | Anesthesiology2008，108，： | 1 |
| 16 | Ambulatory continuous femoral nerve blocks decrease time to discharge readiness after tricompartment total knee arthroplasty : a randomized, triple-masked, placebo-con- trolled study显示文摘 | Iifeld BM Le LT Meyer RS | 2008 | Anesthesiology2008，108，4： | 1 |
| 17 | Surface enhanced Raman scattering enhancement factors:a comprehen sive study显示文摘 | LE RUE C BLACKIE E MEYER M | 2007 | J Phys Chem C2007，111，13： | 1 |
| 18 | Resiquimod,a topical drug for viral skin lesions and skin cancer显示文摘 | Meyer T Surber C French LE | 2013 | Expert Opinlnvestig Drugs2013，22，1： | 1 |
| 19 | Ambulatory continuous femoral nerve blocks decrease time to discharge readiness after tricompartment total knee arthroplasty : a randomized, triple-masked, placebo-con- trolled study 显示文摘 | Ilfeld B M Le L T Meyer R S | 2008 | Anesthesiology2008，108，4： | 1 |
| 20 | In vivo confocal scanning laser microscopy: comparison of the reflectance and fluorescence mode by imaging human skin 显示文摘 | Meyer LE Otberg N Sterry W | 2006 | J Biomed Opt2006，11，04： | 1 |
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