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| 1 | Potential predictive factors for pathologic complete response after the neoadjuvant treatment of rectal adenocarcinoma:a single center experience显示文摘Objective:To assess the response rate of patients with rectal adenocarcinoma to neoadjuvant therapy and to identify the predictors of histological regression after neoadjuvant radiotherapy(RT)or concurrent chemoradiotherapy(CCRT).Methods:This study recruited 64 patients.The patients had resectable cancer of the lower and the middle rectum(T3/T4 and/or N+)without distant metastasis and received neoadjuvant RT or CCRT followed by radical surgery with total mesorectal excision(TME)between January 2006 and December 2011.The patients were classified into non-response(NR),partial response(PR),and pathologic complete response(p CR)based on the Dworak tumor regression grading system.Results:The median age of patients was 57 years(ranging from 22 to 85).A total of 24 patients were treated with neoadjuvant CCRT,whereas 40 patients were treated with RT alone.Abdominoperineal resection(APR)was performed on 29 patients(45%).Anterior resection with TME was performed on 34 patients(53%).One patient had local resection.Histologically,12(19%),24(73%),and 28(44%)patients exhibited p CR,PR,and NR,respectively.Univariate analysis revealed that the predictors of tumor regression were as follows:the absence of lymph node involvement from initial imaging(c N0)(P=0.021);normal initial carcinoembryonic antigen(CEA)level(P=0.01);hemoglobin level≥12 g/dl(P=0.009);CCRT(P=0.021);and tumor downstaging in imaging(P=0.001).Multivariate analysis showed that the main predictors of p CR were CT combined with neoadjuvant RT,c N0stage,and tumor regression on imaging.Conclusions:Identifying the predictors of p CR following neoadjuvant therapy aids the selection of responsive patients for nonaggressive surgical treatment and possible surveillance. | Feryel Letaief Meher Nasri Mouna Ayadi Khedija Meddeb Amina Mokrani Yosra Yahyaoui Nesrine Chraiet Henda Raies Amel Mezlini | 2017 | Cancer Biology & Medicine2017，14，3： | 3 |
| 2 | Status of antioxidant enzyme: glutathione peroxidase and total polyphenol level in plasma of Tunisian patients suffering from colorectal and gastric cancer: interaction with clinical outcome显示文摘 | Baroudi O Younes S B Mezlini A | 2013 | Med Oncol2013，30，4： | 1 |
| 3 | Tribological Behavior of CoCr28Mo/CoCr28Mo Pair in the Presence of Bio-lubrication显示文摘 | Manel Guezmil Walid Bensalah Salah Mezlini | 2018 | Journal of Bionic Engineering2018，15，4： | 1 |
| 4 | Similarity network fusion for aggregating data types on a genomic scale显示文摘 | WANG B MEZLINI A M DEMIR F | 2014 | Nat Methods2014，11，3： | 1 |
| 5 | Impact of lifestyle factors and nutrients intake on occurrence of gastroin- testinal cancer in Tunisian population显示文摘 | BAROUDI O CHAABEN AB MEZLINI A | 2014 | Tumour Biol2014，35，6： | 1 |
| 6 | On Some Tribological Effects of Graphite Nodules in Wear Mechanism of SG Cast Iron: Finite Element and Experimental Analysis 显示文摘 | BEN T M MEZLINI S MANSORI M E | 2009 | Wear2009，267，： | 1 |
| 7 | Thymidylate synthase polymorphism in sporadic colorectal and gastric cancer in Tunisian population: a predictive role in 5-fluorouracil based chemotherapy treatment显示文摘 | Olfa Baroudi Thouraya Baroudi Ines Omrane Amel Moussa Amel Mezlini Hajer Ayari Sami Guermazi Abdesslem Bahloul Hassen Bouzaienne Nancy Uhrhammer Yves Jean Bignon Amel Benammar El-Gaaied Karim Bougatef | 2014 | Medical Oncology2014，，2： | 1 |
| 8 | Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer patients with advanced stage and lymph node metastasis显示文摘 | Ines Omrane Olfa Baroudi Nadia Kourda Yves-Jean Bignon Nancy Uhrhammer Alexis Desrichard Imen Medimegh Hager Ayari Nejla Stambouli Amel Mezlini Hssan Bouzayenne Raja Marrakchi Amel Benammar-Elgaaid Karim Bougatef | 2014 | Tumor Biology2014，，1： | 1 |
| 9 | Effect of indenter geometry and relationship between abrasive wear and hardness in early stage of repetitive sliding显示文摘 | MEZLINI S KAPSA Ph ABRY J C | 2006 | Wear2006，260，： | 1 |
| 10 | Tribological Investigation of HDPE-cuttlebone and HDPE-red Coral Composites显示文摘In this paper,the tribological properties of cuttlebone(CB)-reinforced high density polyethylene(HDPE)and Red Coral(RC)-reinfbrced HDPE composites were investigated.The composite specimens were prepared with a hot compression molding machine using different weight proportions of fillers blended with HDPE.The tribological behavior of the composite disks was studied using pin-on-disk tribometer under dry condition against stainless steel M30NW pins.The coefficient of friction as well as wear rate were examined to study the effects of the two fillers on the tribological perfonnance of both composites.After wear tests,different composites were examined using a Scanning Electron Microscope(SEM).It was fbund that the use of cuttlebone(CB)and Red Coral(RC)as reinforcement improved the tribological properties of HDPE. | Amira Salem Walid Bensalah Salah Mezlini | 2019 | Journal of Bionic Engineering2019，16，6： | 0 |
| 11 | Testicular Synovial Sarcoma:A Case Report显示文摘This paper reports a case of testicular synovial sarcoma with molecular genetic analysis.A 24-year-old male presented with painless scrotal mass.Ultrasonography showed a heterogeneous mass of 66 mm×34 mm in size involving the inguinal region.Histological examination of a surgical biopsy showed a gradeⅢmonophasic growth pattern of spindle cell proliferation.Immunohistochemical analyses indicated positive staining for pancytokeratine and epithelial membrane antigen.Cytogenetic analysis showed the presence of CYT-SSX1 mutation,and CT scan showed non-specific pleural micro-nodules with a size of 7.5 mm.The patient had an extended left orchidectomy but was lost to follow-up for 1 year.A local recurrent scrotal mass of 32 mm×25 mm,multiple inguinal lymph nodes,and increased pleural nodules,which were confirmed by histological examination,were treated with three cycles of adriamycine and ifosfamide chemotherapy,surgical resection,and radiotherapy with complete response.After 3 months,the patient developed local recurrence and pulmonary metastases that did not respond to second-line chemotherapy based on gemcitabine and paclitaxel.The patient had dyspnea at the time of this writing and chest pain,and is under third-line chemotherapy based on Deticene after 30 months of following up.This patient died on November 16,2012 after a resperatory failure and malignant plural effusion. Synovial sarcoma should be considered in the differential diagnosis of soft tissue tumor and it should be aggressively treated to improve prognosis.Although our patient has shown numerous factors of bad prognosis,he has had a relatively long survival time. | Mejri Nesrine Rym Sellami Raoudha Doghri Hela Rifi Henda Raies Amel Mezlini | 2012 | Clinical oncology and cancer resexreh2012，9，4： | 0 |
| 12 | ON RUBIN'S HARMONIC ANALYSIS AND ITS RELATED POSITIVE DEFINITE FUNCTIONS显示文摘In this paper,a new formulation of the Rubin's q-translation is given,which leads to a reliable q-harmonic analysis.Next,related q-positive definite functions are introduced and studied,and a Bochner's theorem is proved. | Nji Bettaibi Kamel Mezlini Moufida El Gunichi | 2012 | Acta Mathematica Scientia2012，32，5： | 0 |
| 13 | GENERALIZED DISCRETE Q-HERMITE I POLYNOMIALS AND Q-DEFORMED OSCILLATOR显示文摘In this paper, we present an explicit realization of q-deformed Calogero-Vasiliev algebra whose generators are first-order q-difference operators related to the generalized discrete q-Hermite I polynomials recently introduced in [14]. Furthermore, we construct the wave functions and we determine the q-coherent states. | Kamel MEZLINI Neji BETTAIBI | 2018 | Acta Mathematica Scientia2018，38，4： | 0 |
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