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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Personal omics profiling reveals dynamic molecular and medical phenotypes显示文摘 | CHEN R MIAS G I LI-POOK THAN J | 2012 | Cell2012，148，6： | 1 |
| 3 | Personal omics profiling reveals dynamic molecular and medicalphenotypes 显示文摘 | CHEN R MIAS G I LI-POOK-THAN J | 2012 | Cell2012，148，6： | 1 |
| 4 | Entrained oxide films in TiAl castings显示文摘 | MIA J HARDINGB R A WICKINSB M | 2003 | Intermetallics2003，，11： | 1 |
| 5 | Short-term variations and long-term changes in oak productivity in northeastern France:the role of climate and atmospheric CO2显示文摘 | Becker M Nieminen T M Gérémia F | 1994 | Annales des Sciences Forestières1994，51，5： | 1 |
| 6 | Toll - like receptor (TLR) 7 and TLR8 expression on CD133 + ceils in colorectal cancer points to a specific role for inflammation - induced TLRs in tumourigenesis and tumour progression 显示文摘 | Martin G Mia Kim Andreas R | 2010 | European J Cancer2010，46，： | 1 |
| 7 | Evaluation of hormone replacement therapy 显示文摘 | Siddiqui N I Rabman S Mia A R et a| | 2005 | Mymensingh Med J2005，14，2： | 1 |
| 8 | Personal omics profiling reveals dynamic molecular and medical phenotypes显示文摘 | Chen R Mias GI Li-Pook-Than J | 2012 | Cell2012，148，6： | 1 |
| 9 | Evaluation of hormone replacement therapy显示文摘 | Siddiqui N I Rahman S Mia A R | 2005 | Mymensingh Med J2005，14，2： | 1 |
| 10 | Evaluation of Hor-mone repla-cementtherapy 显示文摘 | SiddiquiN I Rahman S Mia A R | 2005 | Mymensingh Med J2005，14，2： | 1 |
| 11 | Colloids venus crystalloids for fluid resuscitation in critically ill patients 显示文摘 | Pablo P Ian R Mia P | 2007 | Cochrane Database Systematic Reviews2007，4，3： | 1 |
| 12 | Differential gene expression of MMP-1, TIMP-I and HGF in clinically involved and uninvolved skin in South Africans with SSc显示文摘 | Frost J Ramsay M Mia R | 2012 | Rhemnatology (Oxford)2012，51，6： | 1 |
| 13 | Low power field genenration for magneto-optic fiber-based interferometric switches显示文摘 | PRITCHARD J MIA M WEBER R J | | 0，，07： | 1 |
| 14 | Direct FAME synthesis for rapid total lipid analysis from fish oil and cod liver oil 显示文摘 | Indarti E Majid MIA Hashim R | 2005 | J Food Comp Anal2005，18，： | 1 |
| 15 | Biochemical and physical factors affecting discoloration characteristics of 19 bovine muscles 显示文摘 | MCKENNA D R MIAS P D BAIRD B E | 2005 | Meat Sciencem2005，70，： | 1 |
| 16 | Induction of prolonged tolerance to thirdparty skin grafts following fully allogeneic bone marrow transolantation in mice显示文摘 | Mia L Yair R | 1993 | Transplantation1993，55，3： | 1 |
| 17 | Evaluation of hormone replacement therapy显示文摘 | Siddiqui N I Rahman S Mia A R | 2005 | Mymensingh Med J2005，14，2： | 1 |
| 18 | Trends in ecosystem service research: early steps and current drivers显示文摘 | PETrER V MIA R MARI W | 2010 | AMBIO--A Journal of the Human Environment2010，39，4： | 1 |
| 19 | Personality and motivations asso-ciated with Facebook use 显示文摘 | CRAIG R EMILY SO MIA S | 2009 | Comp Hum Behav2009，25，2： | 1 |
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