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4篇 您的检索式：作者名="Michael Graeber"

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		题名	作者	年代	出处	被引量
	1	Clinical pharmacokinetics profile of ivermectin 1% cream after dermal applications on the face显示文摘AIM: To investigate the pharmacokinetics profile of Ivermectin 1% cream after topical treatment in patients with papulopustular rosacea(PPR).METHODS: Ivermectin 1% cream is a new, effective, and safe treatment for PPR. The human pharmacokinetic(PK) profile of ivermectin and its circulating metabolites were assessed following topical application of ivermectin 1% cream to the face. Clinical PK assessments were conducted after 4 wk of treatment using healthy volunteers and PPR subjects. Additionally, PK sampling was conducted up to 1 year of treatment in clinical phase 3 studies. Plasma concentrations of ivermectin and ivermectin metabolites were determined using high-performance liquid chromatography with fluorescence detection after a specific derivation to increase sensitivity.RESULTS: Systemic exposure to ivermectin was quantifiable at low levels in healthy and moderate to severe PPR subjects following the first topical application of ivermectin 1% cream(mean Cmax of 0.5 ± 0.2 ng/mL and 0.7 ± 0.5 ng/mL in healthy volunteers and PPR subjects, respectively). Ivermectin plasma levels reached a plateau after 2 wk of repeated topical application, indicating that steady-state concentrations had been reached. No further ivermectin plasma accumulation was observed during the long-term clinical studies that investigated ivermectin treatment up to 1 year. Investigation of ivermectin metabolites indicated that 2 circulating metabolites represented more than 10% of parent drug systemic exposure at steady state. Repeated topical application of ivermectin 1% cream resulted in lower systemic exposure levels when compared with orally administered ivermectin, suggesting limited transdermal absorption of ivermectin. Topically applied ivermectin is cleared from the plasma slowly(with a prolonged plasma half-life when compared to the oral route).CONCLUSION: Applications of ivermectin 1% cream result in low systemic exposure levels. Steady–state conditions are achieved by 2 wk without further accumulation under chronic treatment.	Khaled Benkali Fran?ois Rony Michael Graeber Jean Jacovella Jean-Paul Chappuis Marie-Helene Peirone Michel Poncet Stéphane Delage Ronan Bouer Nathalie Wagner	2016	World Journal of Dermatology2016，5，1：	1
	2	A new technology for fluidic microsystems based on PCB technology显示文摘	Tobias Merkel Michael Graeber Lienhard Pagel	1999	Sensors and Actuators1999，77，：	1
	3	A New Technology for Fluidic Microsystems Based on PCB Technology显示文摘	Tobias Merkeh Michael Graeber Lienhard Pagel	1999	Sensors and Actuators1999，77，：	1
	4	A new technology for fluidic microsystems based on PCB technology 显示文摘	Tobias Merkel Michael Graeber Lienhard Pagel	1999	Sensors and Actuators1999，77，2：	1

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