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| 1 | Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation显示文摘瞄准:在 thromboembolism 的开发在胰腺的癌症和它的角色学习织物因素(TF ) 的表示。方法:TF 表示被北污点和间接免疫荧光在八根人的胰腺的癌房间线学习。或者拼接的 TF (asTF ) 的表示被 RT-PCR 估计。另外, TF 表示被免疫荧光与胰腺的腺癌(PCa ) 在 19 个病人的胰腺的纸巾决定,有慢性胰炎(CP ) 的 9 个病人和 20 正常控制。血浆样品(30 PCa 病人, 13 CP 病人和 20 控制) 为可溶的 TF 层次和凝结激活标记被调查[thrombin-antithrombin III 建筑群(梭织) ,凝血素碎片 1 + 2 (F1 + 2 )] 。结果:所有胰腺的癌房间线表示了 TF (8/8 ) ,他们中的大多数表示了 asTF (6/8 ) 。在蛋白质水平的 TF 表示没与癌房间线的区别相关。几乎,二件胰腺的癌症组织样品染色了为 TF (17/19 ) 积极。在 CP 的所有样品,弱染色被限制为胰腺的管房间,而一些仅仅内皮下房间在正常控制的 9/20 是积极的。TF 并且在 PCa 病人梭织层次而 2 铺平的提高的 F1 + 没与控制相比到达统计意义,显著地与控制相比被提高。在病人们梭织的 CP 和 F1 + , 2 个层次证明了显著地与控制相比被提高,尽管梭织举起少些比在 PCa 病人被读。结论:我们结束那除了起来房间膜上的 TF 的调整表示,可溶的 TF 可能在胰腺的癌症贡献凝结系统的激活。 | Stephan L Haas Ralf Jesnowski Michael Steiner Frank Hummel Jrg Ringel Christine Burstein Horst Nizze Stefan Liebe J Matthias Lhr | 2006 | World Journal of Gastroenterology2006，12，30： | 9 |
| 2 | An Aggressive Presentation of Colorectal Cancer With an Atypical Lymphopreliferative Pattern of Meta- static Disease : A Case Report and Review of the Literature 显示文摘 | Sonali MS Michael HR Gabriel KG | 2014 | Clinical Colorectal Cancer2014，13，3： | 1 |
| 3 | Treatment of experimental pancreatic cancer by doxorubicin-, mitoxantrone-, and irinotecan-drug eluting beads显示文摘 | Vugar Yagublu Natavan Caliskan Andrew L. Lewis Ralf Jesenofsky Lala Gasimova J. -Matthias L?hr Michael Keese | 2013 | Pancreatology2013，，1： | 1 |
| 4 | Review of current clinical biomarkers for the detection of alcohol dependence显示文摘 | Tavakoli HR Hull M Michael Okasinski L | 2011 | Innov Clin Neurosci2011，8，3： | 1 |
| 5 | MDR1 and ERCC1 Expression Predict Outcome of Patients with Locally Advanced Bladder Cancer Receiving Adjuvant Chemotherapy显示文摘 | Andreas-Claudius Hoffmann Peter Wild Christina Leicht Simone Bertz Kathleen D. Danenberg Peter V. Danenberg Robert St?hr Michael St?ckle Jan Lehmann Martin Schuler Arndt Hartmann | 2010 | Neoplasia2010，，： | 1 |
| 6 | Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole,itraconazole,and Candida infections 显示文摘 | John HR Michael AP John NG | | Clin Infect Dis0，，： | 1 |
| 7 | ERGO: A pilot study of ketogenic diet in recurrent glioblastoma显示文摘 | Johannes Rieger Oliver B?hr Gabriele Maurer Elke Hattingen Kea Franz Daniel Brucker Stefan Walenta Ulrike K?mmerer Johannes Coy Michael Weller Joachim Steinbach | 2014 | International Journal of Oncology2014，，6： | 1 |
| 8 | Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease显示文摘 | Oliver St?hr Katharina Schilbach Lorna Moll Moritz M. Hettich Susanna Freude F. Thomas Wunderlich Marianne Ernst Johanna Zemva Jens C. Brüning Wilhelm Krone Michael Udelhoven Markus Schubert | 2013 | AGE2013，，1： | 1 |
| 9 | Extravascular use of drug-eluting beads: A promising approach in compartment-based tumor therapy显示文摘Intraperitoneal carcinomatosis(PC)may occur with several tumor entities.The prognosis of patients suffering from PC is usually poor.Present treatment depends on the cancer entity and includes systemic chemotherapy,radiation therapy,hormonal therapy and surgical resection.Only few patients may also benefit from hyperthermic intraperitoneal chemotherapy with a complete tumor remission.These therapies are often accompanied by severe systemic side-effects.One approach to reduce side effects is to target chemotherapeutic agents to the tumor with carrier devices.Promising experimental results have been achieved using drug-eluting beads(DEBs).A series of in vitro and in vitro experiments has been conducted to determine the suitability of their extravascular use.These encapsulation devices were able to harbor CYP2B1producing cells and to shield them from the hosts immune system when injected intratumorally.In this way ifosfamide-which is transformed into its active metabolites by CYP2B1-could be successfully targeted into pancreatic tumor growths.Furthermore DEBs can be used to target chemotherapeutics into the abdominal cavity for treatment of PC.If CYP2B1 producing cells are proven to be save for usage in man and if local toxic effects of chemotherapeutics can be controlled,DEBs will become promising tools in compartmentbased anticancer treatment. | Simon Binder Andrew L Lewis J-Matthias Lhr Michael Keese | 2013 | World Journal of Gastroenterology2013，19，43： | 0 |
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