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您的检索式：作者名="Michael I.Lindinger"
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| 1 | Review:Do Horses Receive Optimum Amounts of Glutamine in Their Diets?显示文摘In some species of growing mammals glutamine is an essential amino acid that,if inadequate in the diet,is needed for normal growth and development.It is thus sometimes considered to be a conditionally essential amino acid in some species.A review of studies that have measured L-glutamine concentrations([glutamine])in horses demonstrates that plasma[glutamine]has routinely been reported to be much lower(~330μmol/L)than in other mammals(>600μmol/L).Plasma[glutamine]represents the balance between intestinal transport into the blood after hepatic first pass,tissue synthesis and cellular extraction.The hypothesis is proposed that sustained low plasma[glutamine]represents a chronic state of sub-optimal glutamine intake and glutamine synthesis that does not meet the requirements for optimum health.While this may be without serious consequence in feral and sedentary horses,there is evidence that provision of supplemental dietary glutamine ameliorates a number of health consequences,particularly in horses with elevated metabolic demands.The present review provides evidence that glutamine is very important(and perhaps essential)for intestinal epithelial cells in mammals including horses,that horses with low plasma[glutamine]represents a sub-optimal state of well-being,and that horses supplemented with glutamine exhibit physiological and health benefits. | Michael I.Lindinger | 2020 | Veterinary Science Research2020，2，1： | 0 |
| 2 | Dietary Cucumis melo Reduces Markers of Muscle and Articular Inflammation Following High-intensity Exercise in Horses显示文摘We evaluated the antioxidative and anti-inflammatory potential of daily oral supplementation with a proprietary powdered Cucumis melo pulp(CMP)on exercise-induced markers of articular and muscular oxidative stress and inflammation in 12 horses.Horses performed a high-intensity exercise test immediately prior to,and then following,3 weeks of daily supplementation of 1 g powdered CMP(CMP;n=8).Controls(Co;n=8)underwent the same exercise and sampling regime but were not supplemented.Blood and synovial fluid(SF)samples were taken 24 h prior to exercise(BL),and at 1 and 24 h following exercise.Plasma and SF were analysed for prostaglandin E2(PGE2),total antioxidant status(TAS),nitrite and superoxide dismutase(SOD)activity.SF was analysed for glycosaminoglycans(GAG),and plasma was analysed for thiobarbituric acid reactive substances(TBARS).Comparisons were made using repeated measures with the initial exercise test as a covariate.There was an increase in SF SOD activity in the CMP group.Compared to Co at 1 h,CMP reduced nitrite and GAG in SF,as well as maintained plasma TAS and lymphocyte levels.At 24 h,plasma PGE2 and creatine kinase were lower in horses receiving CMP.Three weeks of supplementation with CMP reduced markers of articular and skeletal muscle oxidative stress and inflammation in response to high-intensity exercise in horses.Nutritive antioxidants may provide a useful adjunct to the daily nutrition plan of horses undergoing regular exercise training and competition. | Jennifer L.MacNicol Michael I.Lindinger Anna K.Shoveller John P.Cant Wendy Pearson | 2020 | Veterinary Science Research2020，2，1： | 0 |
| 3 | Integrated Nutraceutical – Nutritional Approaches to Address Equine Leaky Gut Syndrome显示文摘Many of the nutrients beneficial for intestinal health are present in normal foods,but their normal daily intake may be too low to exert optimum effects on intestinal barrier function and immune status.Evidence from laboratory and farm production animals strongly supports dietary supplementation with additional nutrients and nutraceuticals,however research in horses remains scarce and inconclusive.Careful consideration of the outcome desired for horses in care,together with the types of nutraceuticals available,is needed to develop effective strategies for maintenance of healthy intestinal barrier function and for treatment of various leaky gut syndromes in horses.This review presents these issues in the context of what is known about the effects of nutraceutical-type nutrients on the mammalian(including equine)g.i.tract and intestinal microbiome with the aim of providing suggestions for the equine situation. | Michael I.Lindinger | 2019 | Veterinary Science Research2019，1，1： | 0 |
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