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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Fluid overload at initiation of renal replacement therapy is associated with lack of renal recovery in patients with acute kidney injury显示文摘 | Michael H Dawn F Wolfgram MK | 2012 | Nephrol Dial Transplant2012，27，3： | 1 |
| 3 | Usefulness of fragmented QRS on a 12-lead electrocardiogram in acute coronary syndrome for predicting mortality 显示文摘 | Das MK Michael MA Suradi H | 2009 | Am J Cardiol2009，104，12： | 1 |
| 4 | Framented QRS on 12-lead ECG pre- dicts arrhythmie event and mortality in patient with mon-is- chemic eardiomyopathy显示文摘 | Michael MA Das MK | 2006 | Heart Rhythm2006，3，： | 1 |
| 5 | Usefulness of fragmented QRS on a 12-lead electrocardiogram in acute coronary syndrome for predicting mortality显示文摘 | Das MK Michael MA Suradi H | | 0，，12： | 1 |
| 6 | Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: The Hong Kong experience显示文摘 | Michael MK Peter LT Ricky CC | 2004 | Int J Radiation Oncology Biol Phys2004，60，5： | 1 |
| 7 | Fragmented QRS complex on a 12 lead ECG developed during the first 48 hours after acute myocardial in- farction predicts mortality 显示文摘 | Das MK Michael MA Suradi H | 2008 | Circulation2008，118，12： | 1 |
| 8 | Usefulness of fragmented QRS on a 12-Lead electrocardiogram in acute coronary syndrome for predic- ting mortality 显示文摘 | Das MK Michael MA Suradi H | 2009 | Am J C ardiol2009，104，8： | 1 |
| 9 | Fragmented QRS on a 12-lead ECG is a sign of acute or recent myocardialInfarction 显示文摘 | Michael MA Das MK | 2006 | Circulation2006，114，3： | 1 |
| 10 | Neurological disorders caused by inherited ion-channel mutations 显示文摘 | Dimitri MK Michael GH | 2002 | Lancet Neurology2002，1，： | 1 |
| 11 | Cost-effectiveness of alternative management strategies for padents with solitary pulmonary nodules显示文摘 | Michael K Gould MK Gilban D | 2003 | Ann Intern Med2003，343，： | 1 |
| 12 | Incidence of and case fa-tality following acute myocardial infarction in aboriginal and non-aboriginal western Australians(2000-2004):A linked data study显示文摘 | Judith MK Frank MS Michael ST | 2010 | Heart Lung and Circulation2010，19，： | 1 |
| 13 | Usefulness of fragmented QRS on a 12-lead electrocardiogram in acute coronary syndrome for predicting mortality 显示文摘 | Das MK Michael MA Suradi H | 2009 | Am J Cardiol2009，104，12： | 1 |
| 14 | AB50-2:Fragmented QRS on 12-lead ECG predicts arrhythmic event and mortality in patient with non-ischemic cardiomypathy显示文摘 | Michael MA Das MK | | 0，，05： | 1 |
| 15 | Fragmented QRS on 12 lead ECG pre- dicts arrhythmic event and mortality in patient with non is- chemic cardiomyopathy显示文摘 | Michael MA Das MK | 2006 | Heart Rhythm2006，3，： | 1 |
| 16 | Fragmented QRS complex on a twelve-lead electrocardiogram;a predicts arrhytnmia events in pa- tients with ischemic and nonischemic cardiomyopathy显示文摘 | MK Das WC Maskoun MA Michael | 2010 | Heart Rhythm2010，7，1： | 1 |
| 17 | An epidemiological survey of the health needs of disabled people in a rural community显示文摘 | Ruth MK Michael PB | 2000 | Clinical Rehabil- itation2000，14，： | 1 |
| 18 | Heurological disorders caused by inberited ion- channel mutations 显示文摘 | Dimitri MK Michael GH | 2002 | Lancet Neurology2002，1，： | 1 |
| 19 | Usefulness of fragmented QRS on a 12 - lead electrocardiogram in acute coronary syndrome for predicting mortality 显示文摘 | Das MK Michael MA Suradl H | 2009 | Am J Cardiol2009，104，12： | 1 |
| 20 | Role of the renin-angiotensin-aldosterone system in vascular remodeling and inflammation: a clinical review spironoIactone preserves cardiac norepinephrine reuptake in salt-sensitive DahI rats 显示文摘 | Sebastian JB Johannes B Michael MK | 2006 | Endocrinology2006，147，5： | 1 |
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