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| 1 | PDX1.1-dependent biosynthesis of vitamin B6 protects roots from ammonium-induced oxidative stress显示文摘Despite serving as a major inorganic nitrogen source for plants,ammonium causes toxicity at elevated con-centrations,inhibiting root elongation early on.While previous studies have shown that ammonium-inhibited root development relates to ammonium uptake and formation of reactive oxygen species(ROS)in roots,it remains unclear about the mechanisms underlying the repression of root growth and how plants cope with this inhibitory effect of ammonium.In this study,we demonstrate that ammonium-induced apo-plastic acidification co-localizes with Fe precipitation and hydrogen peroxide(H_(2)O_(2))accumulation along the stele of the elongation and differentiation zone in root tips,indicating Fe-dependent ROS formation.By screening ammonium sensitivity in T-DNA insertion lines of ammonium-responsive genes,we identified PDX1.1,which is upregulated by ammonium in the root stele and whose product catalyzes de novo biosyn-thesis of vitamin B6.Root growth of pdx1.1 mutants is hypersensitive to ammonium,while chemical complementation or overexpression of PDX1.1 restores root elongation.This salvage strategy requires non-phosphorylated forms of vitamin B6 that are able to quench ROS and rescue root growth from ammo-nium inhibition.Collectively,these results suggest that PDX1.1-mediated synthesis of non-phosphorylated B6 vitamers acts as a primary strategy to protect roots from ammonium-dependent ROS formation. | Ying Liu Rodolfo A.Maniero Ricardo F.H.Giehl Michael Melzer Priscille Steensma Gabriel Krouk Teresa B.Fitzpatrick Nicolaus von Wirén | 2022 | Molecular Plant2022，15，5： | 3 |
| 2 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 3 | Appearance models based on kernel canonical correlation analysis显示文摘 | Thomas Melzer Michael Horst Bischof | 2003 | Pattern Recognition2003，36，9： | 1 |
| 4 | Detection of Pancreatic Carcinoma (Diagnostic Value of K-ras Mutations in Circulating DNA from Serum)显示文摘 | Livia Theodor Ehud Melzer Michael Sologov Gila Idelman Eitan Friedman Simon Bar-Meir | 1999 | Digestive Diseases and Sciences1999，，10： | 1 |
| 5 | Heterosis manifestation during early Arabidopsis seedling development is characterized by intermediate gene expression and enhanced metabolic activity in the hybrids显示文摘 | Rhonda C. Meyer Hanna Witucka‐Wall Martina Becher Anna Blacha Anastassia Boudichevskaia Peter D?rmann Oliver Fiehn Svetlana Friedel Maria von Korff Jan Lisec Michael Melzer Dirk Repsilber Renate Schmidt Matthias Scholz Joachim Selbig Lothar Willmitzer Tho | 2012 | The Plant Journal2012，，4： | 1 |
| 6 | Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and ento- rhinal cortex 显示文摘 | Melzer S Michael M Caputi A | 2012 | Science2012，335，： | 1 |
| 7 | Long-range-projecting GABA ergic neurons modulate inhibition in hippocampus and entorhinal cortex显示文摘 | Melzer S Michael M Caputi A | | 0，，6075： | 1 |
| 8 | The Risk Of Transmission Of Hepatitis B From Hbsag(-), Hbcab(+), Hbigm(-) Organ Donors显示文摘 | Michael E. Wachs William J. Amend Nancy L. Ascher Peter N. Bretan Jean Emond John R. Lake Juliet S. Melzer John P. Roberts Steve J. Tomlanovich Flavio Vincenti Peter Stock | 1995 | Transplantation1995，，2： | 1 |
| 9 | Detection of Pancreatic Carcinoma (Diagnostic Value of K-ras Mutations in Circulating DNA from Serum)显示文摘 | Livia Theodor Ehud Melzer Michael Sologov Gila Idelman Eitan Friedman Simon Bar-Meir | 1999 | Digestive Diseases and Sciences1999，，10： | 1 |
| 10 | Mesalamine Did Not Prevent Recurrent Diverticulitis in Phase 3 Controlled Trials显示文摘 | Jeffrey B. Raskin Michael A. Kamm M. Mazen Jamal Juan Márquez Ehud Melzer Robert E. Schoen Tibor Szalóki Karen Barrett Paul Streck | 2014 | Gastroenterology2014，，4： | 1 |
| 11 | Appearance models based on kernel canonical correlation analysis显示文摘 | Thomas Melzer Michael Reiter Horst Bischof | 2003 | Pattem Recognition2003，1，36： | 1 |
| 12 | Restoration of submerged vegetation in shallow eutrophic lakes – A guideline and state of the art in Germany显示文摘 | Sabine Hilt Elisabeth M. Gross Michael Hupfer Harald Morscheid Jens M?hlmann Arnulf Melzer Jens Poltz Stefan Sandrock Eva-Maria Scharf Susanne Schneider Klaus van de Weyer | 2006 | Limnologica2006，，3： | 1 |
| 13 | Immunoelectron Microscopy for Locating Calvin Cycle Enzymes in the Thylakoids of Synechocystis 6803显示文摘单细胞的 cyanobacteria Synechocystis 6803 用高压的结冰被修理(HPF ) 并且没有任何化学药品,冻结替换跨连接器。这些房间的 Immunoelectron 显微镜学证明喀尔文的五顺序的酶骑车(phosphoriboisomerase, phosphoribulokinase, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO ) , 3-phosphoglyceratekinase 和 glyceraldehyde-3-phosphate 脱氢酶) 并且叶绿体 H+-ATP synthase (CF1 ) 的催化部分被定位邻近 thylakoid 膜。Synechocystis 的没有房间的摘录被 ultracentrifugation 处理在 40 点孤立 thylakoid 部分 sedimenting ? 000, 90 ? 000,和 150 ? 000 ? g。在这些之中, 150 ? 000-g 部分显示出上述五顺序的加尔文周期酶并且也的最高连接的活动由 ribose-5-phosphate (R-5-P ) 估计了的轻、黑暗的反应的最高协调的活动 +ADP 依赖 CO2 固定。这膜部分标记的 Immunogold 象 CF1 ATP synthase 的催化部分一样证实了上述五酶的存在。尤其是,没有跨连接器的化学药品的使用, thylakoids 标记的蛋白质 A 黄金被观察,尽管有洗的正常,步在标准 immunolabeling 期间使用了。结果证明可溶的加尔文周期酶可能沿着 thylakoid 膜被组织。 | Rachna Agarwal Stefan Ortleb layashree Krishna Sainis Michael Melzer | 2009 | Molecular Plant2009，2，1： | 0 |
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